Somapolis
Greenlighter
- Joined
- Jan 8, 2008
- Messages
- 26
swilow said:http://www.maps.org/research/cluster/psilo-lsd/
Check that link out brother....And welcome to Bluelight, I hope you enjoy your stay...
Thank you. I'm sure I will.
When I first got diagnosed with cluster headache I had no clue that psychedelics, or shall I say exclusively tryptamins, would be able to help me. But when I read about clusterbusters it all made sense. I mean actually it was treatment for migraine mr Hofmann was looking for to start with (happy birthday btw Albert!)
At the time I first got an attack I've only tested LSD and psilocybin shrooms a couple of times. Now the list is a bit longer and includes a variety of "exotic" tryptamines but also a lot of phenetylamines particulary in the 2C- family. It would be an understatement to say that may interest in psychedelics grew at this time in my life.
I know close to nothing about chemistry so I'm very thankful if someones who does is able to explain for me in a simple matter the of function of the triptans and the similarities with tryptamines.
I know that my own medicine, Sumatriptan is a an agonist for the 5-HT1D and 5-HT1B receptors and that most of the pschedelics, trypts anyway?, are 5-HT2a agonist.
The intense pain that you experience from CH is caused by the dilation of blood vessels which creates pressure on the trigeminal nerve. When it comes to acute treatment I therefore think that Sumatriptan IM is excellent because you'll need a really quick painrelief. But what I'm trying to find out theoretically is if an IM injection of lets say 4-AcO-DMT would have the same effect. The specific receptor subtype Sumatriptan activates is present in the cranial and basilar arteries. Activation of these receptors causes vasoconstriction of those dilated arteries. Sumatriptan is also shown to decrease the activity of the trigeminal nerve, which probably accounts for Sumatriptan's efficacy in treating cluster headaches. Is the decrease of activity in the trigerminal nerve a consequence of the vasoconstriction?
I havent had the chance to use Methysergide but of what I can understand it works both as a agonists and a antagonist on the serotonine receptors? Could anybody explain why that is supposed to work prophylactic?
I've personally got the feeling that my periods with CH starts when the seasons changes, heard this disease is quite uncommon near the equator, and is directly linked to the production of melatonine and the circadian rythm.
I'm also very interested to hear more about nanobrains experiences of phenteylamines and tryptamines with CH. Could you please fill in some details about all that and tell a bit more about your condition today.