propylhexedrine question

[StaySedated]

off topic, but......


does anyone know which receptors propylhexedrine binds to, and in what ratio? why is it so hard to find receptor binding info on this substance, it's been around forever.

i've searched and haven't found any specific binding affinites but from my experience with it and the info i have read about it propylhexedrine's binding affinites are probably very close to those of methamphetamine and amphetamine.

i think like methamphetamine and unlike amphetamine propylhexedrine has some affinity for releasing serotonin. as for dopamine i think its probably slightly less than methamphetamine and dextroamphetamine and for releasing norepinephrine its about the same.

 

[indelibleface]

A theory I`ve heard about the entactogenic properties of propylhexedrine (as stated by I believe ebola?) is that it could be a weird emergent property stemming from both the dopamine/norepinephrine release and the adrenergic effects. To my knowledge, propylhexedrine does not exert significant serotonin effects. It does, definitely, in my opinion as well as others, have effects that certainly mimic serotonin release, or what at least we associate with serotonin release.

That said, I`m just happy it`s legal and easy to come by. That`s really its advantage over other similar stimulants, although I have to say, it definitely has a character of its own. And I might be the first to admit that I enjoy the flavor of a cotton soaked in propylhexedrine mixed in a beverage of Diet Coke and lemon juice. Minty fresh!

 

[Sentience]

And amphetamines aren't really "based on" ephedrine per se.

Ephedrine is beta-hydroxy methamphetamine. So meth can (and is) easily created by removing that hydroxy group from ephedrine. But that's where the similarity ends.

Yes they are. Ephedrine is the naturally occurring drug that was used in traditional medicine that lead to the research that lead to amphetamines.

Ephedrine was not discovered by adding a hydroxy group to ephedrine. Ephedrine was the naturally occurring compound that was used as a base in early research.

Believe it or not, most drugs are based on naturally occurring compounds first.

Ephedrine is a 3rd grade stimulant. It has way more side-effects than central stimulant effects, it has severe health risks, it's not very euphoric, etc. etc.

The Ma Huang plant, or Sida Cordifolia both have a barrage of chemicals in them, and I find Ma Huang to be more euphoric on its own compared to mini thins.

 

[dread]

Yes they are. Ephedrine is the naturally occurring drug that was used in traditional medicine that lead to the research that lead to amphetamines.

Ephedrine was not discovered by adding a hydroxy group to ephedrine. Ephedrine was the naturally occurring compound that was used as a base in early research.

Believe it or not, most drugs are based on naturally occurring compounds first.

Yawn... you're not telling me anything new here.

Firstly, in order to define what chemical is based on what we need to define what "based on" means.

If we define it purely from a historical perspective then sure I guess you could say amphetamines are "based on" ephedrine. But defining chemicals based on what they first were synthetized from seems sort of arbitrary to me, since you can synthesize amphetamines from various starting materials and by various methods.


My point is, that claiming all amphetamines are "based on" ephedrine is fallacious, because ephedrine is itself an amphetamine.