Opioids Propoxyphene HCL

[hatrix]

So I've read all the Darvocet/Darven warnings that they can cause heart problems, kill you, etc. But I'm going to go out on a limb and say even though it's now recalled, it was in use for many years and many people used it without any incidence.

Another note I'd like to add, most people who ask about it have it in the form Propoxyphene Napsylate which always contains APAP (at least form what I have read), adding to the dangers of going for a "recreational" dose.

Now I have just pure Propoxyphene HCL, 65mg tabs pill capsule id 93 741. After looking it up, there is no mention of them containing APAP. I have literally no opiate tolerance and have some slight anxiety right now. I was kind of looking to take away the anxiety while getting the slight warm buzz these can provide, though I know it's very mild in comparison to say hydrocodone.

I have 4 65mg pills. They are definitely a bit dated.... but I doubt there has been any potency loss.

How safe is it to take ? Am I really in danger of heart failure or something from taking 2-4 of these ONE time ? A friend came across it in an old collection of meds and since it's been recalled it's not like I'm going to be doing it again. Just wondering if it's worth the time of someone who has literally no opiate tolerance.

Sorry if this is more appropriate for BDD, move as needed.

 

[sekio]

Am I really in danger of heart failure or something from taking 2-4 of these ONE time

No, probably not, but if you chase a high with them regularly, you can expect to have more than your fair share of OD scares.
Propoxyphene is a local anesthetic, like lidocaine, so it can fuck with heart rhythms - this combined with opioid f/x reducing respiratory ate is not good and leads to the LD50 being considerably lower than you'd expect

The reason that propoxyphene was recalled was because the theraputic window is so small in comparison to other drugs like codeine or tramadol. Realistically, I wouldn't take more than 2x the "prescribed" dose, and even then I wouldn't combine them with anything stronger than marijuana.

It doesn't help that mg-for-mg propoxyphene is one of the weaker opioids too.

 

[hatrix]

Ok, good info I appreciate the reply. So as far as dosage goes, I'm safe taking all 260mg at once ? The prescribed dose on the bottle is 2 capsules every 4 hours.

Also, what IS the LD50 of Propoxyphene HCL ?

 

[hootar]

If you're opiate naive honestly just take two... The high with those cruddy pharms doesnt change much after the initial come on, regardless of how much you take. and you can always take more, you can never take less. you'd feel awful dumb all corpsified from darvocet, if you could feel anything at all.

 

[tricomb]

There's a reason it was used as the primary ingredient in lethal injections here in prisons in the United States.

It has like no recreational value, even if you have like no tolerance whatsoever.

It's a shit chemical that was rightfully shit-binned, IMO.

LD50 = ~500mg IIRC, totally unaaceptable if you ask me, you're attempting to take more than 1/2th of the LD50.

Both propoxyphene and norpropoxyphene are potent blockers of cardiac membrane sodium channels and are more potent than lidocaine, quinidine, and procainamide in this respect.[14] As a result, propoxyphene and norpropoxyphene appear to have the characteristics of a Vaughn-Williams Class Ic antiarrhythmic.

These direct cardiac effects include decreased heart rate (i.e. cardiovascular depression), decreased contractility, and decreased electrical conductivity (i.e., increased PR, AH, HV, and QRS intervals). These effects appear to be due to their local anesthetic activity and are not reversed by naloxone.[12][13][15] Widening of the QRS complex appears to be a result of a quinidine-like effect of propoxyphene, and sodium bicarbonate therapy appears to have a positive direct effect on the QRS dysrhythmia.[16]

http://en.wikipedia.org/wiki/Dextropropoxyphene#Toxicity

 

[hatrix]

There's a reason it was used as the primary ingredient in lethal injections here in prisons in the United States.

It has like no recreational value, even if you have like no tolerance whatsoever.

It's a shit chemical that was rightfully shit-binned, IMO.

LD50 = ~500mg IIRC, totally unaaceptable if you ask me, you're attempting to take more than 1/2th of the LD50.


http://en.wikipedia.org/wiki/Dextropropoxyphene#Toxicity

Thanks for the info tricomb. I'll probably just throw it away then.

 

[tentram]

^that'd be what i would do too! wise choice, friend

the risk vs reward just really ain't worth it for a likely non-existent "high"