Promethazine Enhancing the effects of Opioids

[Them Witches]

On the topic of detoxification, I remember long ago Britlofex (lofexidine) was launched specifically for that purpose. Apparently it's still in use in a low-key manner, but I just recall a friend who was a nurse bringing me all of the very impressive looking marketing giveaways when it was announced.

my kind of nurse

 

[Them Witches]

Yeh I agree, clonidine is a very underrated compound.
Orphenadrine citrate is a skeletal muscle relaxant but not a particularly strong one, I haven't tried the medication you mentioned, flexeril is cyclobenzaprine if I remember correctly.

I only take orphenadrine when needed and I generally find a dose of 70mg orally to be helpful for anxiety, as well as analgesia and helps with sleep also.

It is probably worth a try, and as you pointed out, it is prescribed by most Dr's far more freely than benzos.

Similar to Clonidine, Zanaflex operates on and with the alpha2 receptors in the bottom of the brain stem down the spinal cord. both of these drugs work similar and Clonidine stronger. Clonidine is 40x times greater than Xylazine.

Zanaflex (Tizanidine) -- Alpha-2 adrenergic receptor

The alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well. Alpha-2_adrenergic_receptor. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic receptor in the central and peripheral nervous systems.
The α2-adrenergic receptor is classically located on vascular prejunctional terminals where it inhibits the release of norepinephrine (noradrenaline) in a form of negative feedback. It is also located on the vascular smooth muscle cells of certain blood vessels, such as those found in skin arterioles or on veins, where it sits alongside the more plentiful α1-adrenergic receptor, The α2-adrenergic receptor binds both norepinephrine released by sympathetic postganglionic fibers and epinephrine (adrenaline) released by the adrenal medulla, binding norepinephrine with slightly higher affinity.. It has several general functions in common with the α1-adrenergic receptor, but also has specific effects of its own. Agonists (activators) of the α2-adrenergic receptor are frequently used in anaesthesia where they affect sedation, muscle relaxation and analgesia through effects on the central nervous system (CNS).

In the brain, α2-adrenergic receptors can be localized either pre- or post-synaptically, and the majority of receptors appear to be post-synaptic.v For example, the α2A adrenergic receptor subtype is post-synaptic in the prefrontal cortex and these receptors strengthen cognitive and executive functions by inhibiting cAMP opening of potassium channels, thus enhancing prefrontal connections and neuronal firing.vThe α2A-adrenergic agonist, guanfacine, is now used to treat prefrontal cortical cognitive disorders such as attention deficit hyperactivity disorder (ADHD)

Cyclobenzaprine is a centrally acting muscle relaxant with a chemical structure that is very similar to those of tricyclic antidepressants like amitriptyline and imipramine.
Its known actions include serotonin–norepinephrine reuptake inhibition, serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, and 5-HT7 receptor antagonism, α1- and α2-adrenergic receptor antagonism, histamine H1 receptor noncompetitive antagonism, and muscarinic acetylcholine receptor antagonism. In terms of its antimuscarinic activity, it is said to be an antagonist of the muscarinic acetylcholine M1, M2, and M3 receptors, but not of the muscarinic acetylcholine M4 or M5 receptor.

I hope I gave enough information that can help a report

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• https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor

 

[someguyontheinternet]

D2 antagonism Is more busy flushing away excess D2 activity than block psychosis, Because It weaker than the ACH antagonism. If someone did mid-high doses.

but what does that have to do with norepinephrine