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Stimulants Prescription medicines that cancel the dopaminergic effect of amphetamines

S

spacecookie

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Sep 30, 2013
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I'm curious to know if there are prescription drugs that result in the negation of any effect of dopaminergic releasing agents such as MDMA, methamphetamine, or dextroamphetamine. Would atypical antipsychotics such as asenapine (Saphris), SNRIs such as venlafaxine (Effexor), or anticonvulsants such as lamotrigine (Lamictal) interfere with the dopamine release, resulting in a ruined "high"?
 
Thigs like Chlorpromazine(largactil) and other strong anti-psychotics defoe , when I 1st took took Pyrazolam I was really spaced but in a good way , I sniffed 2g of good coke and it hardly touched me.
 
There is only one medication that i know of that is a dopamine antagonist and will interfere with the dopaminergic effects of amphetamines. This medication is an atypical antipsychotic called Quetiapine (Commonly known as Seroquel).

Based on the fact that this medication is an atypical antipsychotic its pretty safe to assume that most atypical antipsychotics are that of the dopamine antagonist nature. This drug will completely shut down any high from amphetamines and knock you out cold in my personal experience. Hope this helped answer part of your question.
 
Lurasidone is an antipsychotic that is a full antagonist at the D2 receptor (among many other effects). When administered after taking amphetamines, it somewhat blunts the high, but has very potent antipsychotic effects. Know those tiny disturbances in vision that are the forerunner to amphetamine psychosis? (eg. staring at window blinds and they seem to be a bit wavy, objects somehow seem to move subtly but you can't identify which ones.) That is my indication it is Lurasidone time, if I still have to get stuff done before sleeping.

Administering in the reverse order (lurasidone first, then amphetamine) results in a lot more in the way of euphoria blunting. But lurasidone alone doesn't make you feel very different, aside from slight upregulation of body temperature and perhaps some mild nootropic effects I honestly couldn't tell you if I was on it or not.
 
Yes, antipsychotics and other antagonists of the dopamine receptors will blunt the high somewhat. Especially the hard core butyrophenones like risperidone. To a lesser extent so will drugs that block norepinephrine and/or adrenaline at adrenergic receptors. (clonidine and such)

Anticonvulsants and SSRI/SNRIs interfere less than antipsychotics.
 
Good question, as I was here searching for some very similar help. I'm on Zyprexa--an atypical anti-psychotic--and also Adderall. I used to be on the dextro years back before without any anti-psychotic and with wonderful results. Now, I hardly feel any of the psychotropic effects of the amphetamine. So I suppose perhaps it's being blocked.
 
I was put in the hospital under the influence of an amphetamine and SSRI (escitalopram) yesterday night, although I consider myself very informant about drugs, more than the ordinary doctor is. Unfortunately I didn't research about the drug interaction too much.

Now I read that: SSRI - do sort of have an affinity on dopamine receptor - similar too serotonin, but too a lesser extent. And there's studys made which says that, SSRI does potentiate the effects of amphetamine in rats.
Fucking retard I am. I was convinced in my mind, that i was dead laying on that bed in hospital. My pulse was raising to 180/beats per minute for like 1 hour. Then it stabilized to 110/beats per minute for 8 hours.

So I was feeling the high of the amphetamine in 18 hours!! Checked out with the same size of dialated pupils as I did when I arrived. I haven't read about that sort of thing anywhere.

Sure, it's labtested at 93% sulfate. The biggest misstake I made was that I never felt an "comfort high" of it, thats why I redosed hour to hour. But I never expected the SSRI to potentiate the effect that much. Heads up for these people. Not funny. I took a total of 150 mg, from 16:00 to 22:30. I took 40mg diazepam and 5 mg Zyprexa, after the hospital to comedown.

Also here it says; you can get serotonin syndrome with Adderall and SSRI, even though it's very rare. http://en.wikipedia.org/wiki/Adderall#Contraindications.2C_interactions.2C_and_precautions

So what happend to me? Could i expect some bigger health issues? It wasn't pleasant. I feel good now, but I'm concerned about my heart. I have an OK stamina.
 
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Clonidine, even at low doses, potently inhibits the high, even though it doesn't act directly on DA.
 
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