Potentiating Vyvanse for the purpose of keeping tolerance down.

[snaggs77]

Hi BDD,

I have ADD,(pretty bad too) and am on 70mg of Vyvanse daily. My Mother controls my pills, because otherwise I would abuse them, though sometimes I can talk her into giving me an extra for rigorous studying purposes. I take off days once in awhile, as well as take 400-500mg of Magnesium citrate or chelated glyinate,(or pop an oxide for the lulz, jk, but seriously) and take a couple of tums or pop two Alka Seltzer Golds in some lukewarm water prior to dosing. I have heard that taking Delsym may work too, but to avoid dosing higher than 60ml

I have ordered Aniracetam, citocholine, and L-dopa pills. On top of that I ordered a book about supplement usage to aid me in my quest to obtain well-being and motivation, on top of concentration.

I have thought about asking my Dr. about Namenda, for the sole purpose of keeping my tolerance down to be able to stay on my dose or even drop down, yet have good results. I have also thought about asking him about augmenting with Strattera or Wellbutrin, but I don't know if there would be negative implications of taking either of these with the Vyvanse.

I also am wondering how much my anxiety and depression are contributing to my lack of focus, but these are well-managed since upping Cymbalta to 120mg and introducing 600mg of Gabapentin. These keep my depression low, and are the greatest anti-anxiety meds I have come across in my 10+ years of being treated. I am 22, in college to be a Psychologist, but am really just getting started since I had alcohol abuse problems, on top of major depression and untreated ADD with poorly treated anxiety. I feel really good right now, but I felt better 2 months ago on 60 mg of Vyvanse. Despite the adequate sense of well-being, I have low self esteem/worth and a lack of drive/motivation. I also procrastinate like no other, but once it's time to crack down, I ace every assignment. This is contributing to anxiety for sure, and maybe leading to a bit of arrogance, since I can do very well, with little effort and time.

I would like to know, basically, what can be done all in all, to reduce tolerance to Vyvanse, or potentiate it, for the purpose of a sustainable healthy dosage, and continued focus and sense of well-being.

I see a counselor once weekly, as well as have regular Doctor visits. These are aimed to improve my thought processes, as well as retrain my brain, and develop new, more responsible behaviors. I would like to get this tolerance issue figured out though, since that and the immature study behavior and lack of motivation, are the missing puzzle pieces that are holding me back. If I can solve this puzzle, I believe I can achieve great success, and be truly happy with a healthy, sustainable existence.

 

[NeighborhoodThreat]

DXM and magnesium can help keep your tolerance from growing as fast as it could, but daily use of amphetamines (any stimulant really) is going to cause tolerance to develop sooner or later.

Supplements do help a lot, but your best bet is to take a break from every once in a while from your Vyvanse.

 

[aveoturbo]

Pill holiday ftw. It will slow the inevitable.

 

[snaggs77]

Did some potentiating today...thought the amount to be used for dxm,(delsym)was 60ml, not 60mg...so I took 6 times the amount by accident, and am dissociated as fuck. On top of that, I took some Pharma kava tincture and Suntheanine. This being on top of the 500 mg of magnesium glycinate(chelated). Not sure what this is doing for helping my tolerance, but right now I'm euphoric. And, shit's legal ...............

 

[~NaStYNaI~]

what if you take dxm AFTER yiuve taken ur vyvanse dose? will that cause pptentiation in any way?

 

[Jabberwocky]

i do not suggest using DXM for potentiating amphetamines or anything for that matter - but especially vyanase. as dxm is very well known for its urinary retention properties and amphetamines are strong diuretics, you can end up with a burst bladder. dxm is also toxic to the body when used for a long extended period of time. it will stop you from developing a tolerance, not reduce it, and that comes with a hefty cost that isnt worth paying.

if you take dxm after the vyvanase, you will probably still be potentiating it. but once again be warned you're putting more strain on your entire cardiovascular system. 60mg of dxm daily will cause problems. if youre going to go down this road i suggest you use at most 5mg at night time. thats it.

take a pill holiday if your tolerance is really getting that high. do you ever use it recreationally? i think here is where your problem has started. it's a good thing your parents control it. i dont mean for this to come across offensive, but you should consider if you really should take this medication or not. i have also had problems with abusing my dexedrine and i have bad adhd. i realised through abusing it, it had lost all of its positive gain and usefulness and led me to a spiral of addiction with lots of other drugs.

i never abuse it now. i always stick to me dose - 40mg a day, 20mg in the morning, 20mg in the afternoon. never more, sometimes less. i sometimes take days off too. i've been sticking to this for the past year and my tolerance has not gone up in the slightest. i dont regularly take supplements, but sometimes i do take chelated magnesium at night (if i can be bothered to buy it) and melatonin frequently which i think also helps keep tolerance down, although i'm not really worried about my tolerance to dex.

 

[nik12937]

Many routes of potentiation also potentiate your increase in tolerance, I'll post specifics if I can remember any.

Usually potenitation is due to your body reacting to a drug's given effects, so regardless of dosage, if you'll feel more "high", your brain is being more psychoactively stimulated as well, making it increase your tolerance to said effects.

 

[Swimmingdancer]

Potentiation and taking something to prevent/reduce tolerance are not the same thing. Many drug potentiators work by increasing the amount of the drug in the bloodstream, so it's pretty much the same for your brain as if you had just taken more of the drug. That wouldn't actually lower your tolerance, it would just enable you to take less of the drug in order to achieve the same effects (and only when you took it with the potentiator).

Then there are things you can take that are said to help slow the progression of tolerance, like magnesium.

And then there are also things (like certain supplements) you can take to help with ADHD that have a different mechanism than stimulant amphetamine drugs, which can enable you to use less amphetamines.

 

[laCster]

Take b vitamins and vitamin c along with a multivitamin . Vitamin b is shown to be effective at treating add as an extra supplement to your meds. I agree with neighbkrhoodthreat aswell in that taking a break is your best bet. I kkow it seems impossible, but it will be good for your brain and body to not be strained so much by the amphetamines.

Magnesium and dxm halt the prevention of tolerance, but does not reduce your tolerance sadly. Make sure not to take the dxm and vyvanse in the same day because the combo puts you at risk for the lethal serotonin syndrome.

Tums and antacids will help by alkalizing your bladder to basic ph which allows for some of the amp to be reabosrbed. however, vyvanse or ylisdexamp must be cleaved by liver before the d amp is absorbed thus being absorbed through the first intestine and not the stomach. Because the lysine must be cleaved off before it works and cannot be taken up in the stomach, antacids won't potentiate the vyvanse.

Another form of boosting the effects of a drug ingesting is by syngergizing the action of amp with other drugs. Synergy doesn't affect the amount of substance absorbed, rather the by adding another drug of a similar or differant class, the effects of both drugs combine and create a super orgy of effects hahaha...my favorite is modafinil added onto my prescribed vyvanse which increases the amount of focus and energy given by the amps. Nicotine also is a good addition to amphetamines, I smoke like a chimney on amphetamines hahaha.

I personally love pregabalin (a suped up version of gabapentin, but they are basically the same drug) and gabapentin is nice too. It works great for anxiety and sleep, but tolerance to these drugs grow rapidly. Pregabalin or lyrica, has better bioavailability and superior absorption kinetics. Also lyrica is roughly three times as potent as gabapentin ...the thing about gabapentin is that uptake of gabapentin highly varies depending onu the contents of your stomach, and supposedly if you take too much, the uptake of neurontin is hindered because the transporter is clogged, much like bumper to bumper traffic. Either way, these are amazing drugs and will help, though gabapentin seems weak to pregabalinx maybe because I have a massive tolerance to these drugs

Id hold off on adding anymore stimulants to the mix because cymbalta increases the amount of synaptic norepinephrine and if taken with other nri's you will feel anxious and uncomfortable. Don't take wellbutrin brecause it also increases the amount of norepinephrine in the cns and willbnot be fun with cymbalta

If your are taking cynbalta, do not take DXM as you will put your risk at serotonin syndrome. Both cymbalya and dxm are snri's