Is it weird that when I first did MDMA (and quite a lot mind you), I didn't have any depression or any of that shit after? I had a nice afterglow, although I'd paired it with shrooms too. From what I understand, MDMA is like... neurotoxic.
Have to eat a few hours before to help with that (my older bro is pretty experienced and it was his bachelor party and he told me it's essential that I have food in my stomach), and I also took a thymoquinone supplement (black seed oils main ingredient) which is neuroprotective. I also was taking mad magnesium glycinate to prevent bruxism, though eventually it caught up with me. I also had magnesium L-threonate which is even more neuroprotective than glycinate might be (not sure, but it's a great nootropic magnesium).
A lot of people I know talk about the post-roll depression, but I didn't get it. I even had 5-HTP on deck just in case, but I never needed it. I have to wonder if the magnesium helped out, or the shrooms, I don't really know to be honest. I just felt incredible for several days after. Hell, none of us had it. We were all fine the next morning, I just felt like I had a very, very mild hangover from drinking 4 beers or something, and mostly because I hadn't eaten like anything after I started rolling, since yeah you don't really want to eat (I did have some pizza before bed though). Was able to pass out only because I'd smoked a half ounce probably. I remember how incredibly soft and cozy the bed was, when it actually was not comfortable at all normally lol.
I guess I should mention I was also staggering Gabapentin which definitely increased the euphoria of the roll, and could also possibly explain why I was ok the next day. Between this, weed, shrooms, it's hard to say.