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Post-roll 5-HTP, guidelines and pitfalls to avoid

Got it. I wasn’t saying, by the way, that one should supplement with 5htp all the time. I don’t think that is safe. I was only suggesting it as a way to restore serotonin after a roll when tryptophan hydroxylase has been depleted. However, I may change my mind about that based on your posts. So, thanks for the info.
Again, it Doesn't matter the reason. If you don't supplement with 5-HTP AND tyrosine AND vitamin B6 which is a necessary co-factor AND vitamin C which is a necessary cofactor. You will have an imbalance of either serotonin or norepinephrine and dopamine because norepinephrine is synthesized from dopamine.
 
If you’re talking about necessary cofactors, I agree it would be good to supplement to make sure you have adequate levels. I believe magnesium is a necessary cofactor for the conversion of 5htp to serotonin, as well as zinc. I don’t believe that tyrosine is a cofactor.

I do not know of any data suggesting that short-term supplementation of 5htp, when serotonin is low, would produce an imbalance of DA or NE.
 
5 hpt combined with ecgc caused serotonin syndrome. This was after 5 mapbs , in 5 mapbs thread, 2015. I'll never use it again after an empathogen.

I think serotonin n does replenish itself. Whoever said it doesn't, show me evidence bc I've never seen it . Noradrenaline and dopamine replenishes much faster and more readily than serotonin .

Ashwaganda for two weeks before the roll and after reduces cortisol, experimenting with.
 
Again, it Doesn't matter the reason. If you don't supplement with 5-HTP AND tyrosine AND vitamin B6 which is a necessary co-factor AND vitamin C which is a necessary cofactor. You will have an imbalance of either serotonin or norepinephrine and dopamine because norepinephrine is synthesized from dopamine.
Do you have any literature on the topic of neurotransmitter imbalance due to supplementation strategy I could read? I think this is an interesting topic and I would like to know more.
 
Again, it Doesn't matter the reason. If you don't supplement with 5-HTP AND tyrosine AND vitamin B6 which is a necessary co-factor AND vitamin C which is a necessary cofactor. You will have an imbalance of either serotonin or norepinephrine and dopamine because norepinephrine is synthesized from dopamine.
Can you explain more why Thyrosine? It doesn’t help 5-HTP cross BBB
 
Is it weird that when I first did MDMA (and quite a lot mind you), I didn't have any depression or any of that shit after? I had a nice afterglow, although I'd paired it with shrooms too. From what I understand, MDMA is like... neurotoxic.

Have to eat a few hours before to help with that (my older bro is pretty experienced and it was his bachelor party and he told me it's essential that I have food in my stomach), and I also took a thymoquinone supplement (black seed oils main ingredient) which is neuroprotective. I also was taking mad magnesium glycinate to prevent bruxism, though eventually it caught up with me. I also had magnesium L-threonate which is even more neuroprotective than glycinate might be (not sure, but it's a great nootropic magnesium).

A lot of people I know talk about the post-roll depression, but I didn't get it. I even had 5-HTP on deck just in case, but I never needed it. I have to wonder if the magnesium helped out, or the shrooms, I don't really know to be honest. I just felt incredible for several days after. Hell, none of us had it. We were all fine the next morning, I just felt like I had a very, very mild hangover from drinking 4 beers or something, and mostly because I hadn't eaten like anything after I started rolling, since yeah you don't really want to eat (I did have some pizza before bed though). Was able to pass out only because I'd smoked a half ounce probably. I remember how incredibly soft and cozy the bed was, when it actually was not comfortable at all normally lol.

I guess I should mention I was also staggering Gabapentin which definitely increased the euphoria of the roll, and could also possibly explain why I was ok the next day. Between this, weed, shrooms, it's hard to say.
 
I feel like I should post here my experience with high doses of 5HTP.

So, some time ago I've ordered a 5HTP supplement with 400mg dose.
And decided to try it. First day I took 1 pill before going to sleep.
In the morning I feel a little bit weird I feel heat in my head, but I didn't make much sense of it. Then I took another one in the morning and one before sleep ~800mg.
At that night I had very bad sleep, and vivid nightmares. Again, I though it was ok.
at the 3rd day I took 2 again and again got strange dreams.
at day 4 I took only 1 pill
At day 5 I didn't take any pills and thats where the "fun" started.

First, I start to feel a little brain zapps in the evening. After that I go to sleep and got horrible nightmares, like I stuck in the dream and can't wake up. I also experienced quite strong sleep paralisys. So after I wake up at day 6 the brain zapps has greatly increased to the level I got a zapped on each step I do. AND I start to hallucinate. Like, I saw a ghostly figures moving around and looking at me. That was quite creepy + I had very bad mental state - like everything looked like alien and bad. When I go sleep I had nightmares with paralysis again and out of body experiences. But in the end I sleep.
In the day 7-9 I still had brain zapps and depressed mood. Then I got some coke and binge it and surprisingly it have kinda reset my brain to the normal state and wiped out depression.

Later on I had similar experience with the MDMA overdose ~1g but less hard and without hallucinations.
 
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