4AllEternity
Greenlighter
Taking antihistamines is a well known way to reduce nausea, though they have a bunch of unpleasant side-effects, most notably drowsiness. Ginger is an alternative, but it tends to have varying effectiveness.
Nausea from mushrooms is likely caused by stimulation of serotonin receptors in the intestines (most notably 5-HT3 and 5-HT4). People often attribute the nausea to mushrooms being "difficult to digest", however at the amount most people ingest, nausea is unlikely to result simply from a couple grams of tough, fibrous plant material. People often eat much larger amounts of very fibrous plant matter (i.e bamboo shoots) without nausea. Stimulating serotonin receptors in the gastrointestinal tract however, consistently produces nausea and anxiety.
The direct solution to this then, is serotonin antagonists. However, serotonin antagonists that easily pass the blood-brain barrier will reduce the effects of psilocybin in the brain, which is undesirable. So that narrows things down to serotonin antagonists with low BBB permeability. There is a much smaller range, however I have found one substance in particular, that is a serotonin antagonist with little CNS action. It's an amino acid available in supplement form, called L-Lysine. Wikipedia has a good description of it. The article mentions the following:
There hasn't been any human studies which have investigated it's use specifically an anti-emetic, though since it theoretically should negate the overstimulation of intestinal serotonin receptors by psilocybin and other oral serotonergic psychadelics, there's a strong possibility it might be of use. I intend to test it myself, and encourage others to do the same. It's cheap and easily available online, and in pharmacy's supplement section.
Nausea from mushrooms is likely caused by stimulation of serotonin receptors in the intestines (most notably 5-HT3 and 5-HT4). People often attribute the nausea to mushrooms being "difficult to digest", however at the amount most people ingest, nausea is unlikely to result simply from a couple grams of tough, fibrous plant material. People often eat much larger amounts of very fibrous plant matter (i.e bamboo shoots) without nausea. Stimulating serotonin receptors in the gastrointestinal tract however, consistently produces nausea and anxiety.
The direct solution to this then, is serotonin antagonists. However, serotonin antagonists that easily pass the blood-brain barrier will reduce the effects of psilocybin in the brain, which is undesirable. So that narrows things down to serotonin antagonists with low BBB permeability. There is a much smaller range, however I have found one substance in particular, that is a serotonin antagonist with little CNS action. It's an amino acid available in supplement form, called L-Lysine. Wikipedia has a good description of it. The article mentions the following:
There hasn't been any human studies which have investigated it's use specifically an anti-emetic, though since it theoretically should negate the overstimulation of intestinal serotonin receptors by psilocybin and other oral serotonergic psychadelics, there's a strong possibility it might be of use. I intend to test it myself, and encourage others to do the same. It's cheap and easily available online, and in pharmacy's supplement section.
