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  • BDD Moderators: Keif’ Richards | negrogesic

Possible OD, should I worry about it?

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ketoz

Bluelighter
Joined
Aug 22, 2014
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146
Hello everybody,

I'm currently quitting opiates and benzos, but yesterday was the kind of day where I couldn't care less and I let the pressure go (hadn't used opiates since a week and a half) by taking methadone. Here is what I took during the day:

-Woke up depressed like pretty much everyday, so I took my treatment which is 50mg amitriptyline and 100mg hydroxyzine. Smoked a cigarette and sipped a coffee.

-2 hours later, I wasn't feeling good at all, like dope sick, freezing and sneezing. I was alone. I had some 40mg methadone pill, so I tried too split that thing in 2 doses, but I maybe did something wrong and took more than 25mg of methadone, I didn't care.

-Just after that, I decided to take more amitriptyline (50mg), hydroxyzine (100mg), aripiprazole (I never took that one very often, 5mg)

-Then I spent the afternoon surfing on the Web, listening to music and reading random stuff.

-Few hours passed and I went out to see a friend who had a car and proposed him to score some herbs for people, before that we had a joint of high grade buds.

After that joint I simply blacked out, the following is told by my friend who freaked out when I saw me coming back to the car:

I couldn't speak or understand anything. Everything I said was incoherent. I had seizure, all my body shut down, I wasn't breathing correctly. My friend tried everything to wake me up and was about to call an ambulance to come to quickly pick me out, he did CPR and was obviously freaking up. He thought I was dying, but I suddenly woke up from my coma, and finally breathed, but it took maybe two hours to be half awake and not nauseous.

Everybody around me is scared and are thinking that I will eventually die... It's no the first time it had happened, last time (a year ago) I woke up in the hospital.

I'm scared. I don't know what to do, or think. I don't understand how that happened.. I was really close to die. Do you think I did a permanent damage? What could be the best thing to do in my situation?

Thank you if you read until there!
Sorry about my poor English... :\ I hope made sense!
 
The amitryptaline is what induced the altered mental status + seizures.

Amitryptaline has a narrow therapeutic range and can very easily induce seizures if it accumulates in your body.

Your physician should have informed you that Amitryptaline interacts with a number of drugs. Specifically Amitryptaline is metabolized by CYP2D6; drugs that inhibit CYP2D6 will cause Amitryptaline to accumulate in your body.

Here's a list of ligands that inhibit or induce CYP2D6: https://en.wikipedia.org/wiki/CYP2D6#Ligands

Note that hydroxyzine, methadone and even cannabidiol (in weed) are strong CYP2D6 inhibitors. So you took a toxic trifecta of CYP2D6 inhibitors plus the Amitryptaline which requires CYP2D6 to be eliminated. Don't be too hard on yourself, I've done far stupider things in my life. Looking forward, you might want to run every substance you co-ingest using an interactions checker. Also, a psychiatrist needs to monitor your amitryptaline levels, especially if you're taking hyrdoxyzine in conjunction.
 
i cant even type in detail that clear sometimes sober so i reckon your ok
and next time when in doubt say fuck it and go to the nearest ER would be a shitty way to die when a simple trip to the hospital couldve saved your life
 
Get medical attention if you think you're in danger. I have to close this. Be safe!
 
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