Possible new PVP analogs?

[Wisoi]

I've been thinking in the last week about what might be coming next in RC land from China now that so many of their precious cathinones are banned. Hopefully they won't keep pumping out garbage, but I've learned to never underestimate their basic ignorance of drug structure-activity relationships and their willingness to cook 50kg batches of absolutely worthless designer drugs. So I started thinking about what logically will they do now? Probably just make some non-banned very horrible aryl ring substituted cathinone or change it by making the carbon chain even longer (with probably worse and worse drugs being made with every new carbon atom on the chain). Then the question that should have been obvious came to me:

Why don't they make some analog of one of the "winners" they already had like MDPV / a-PVP / a-PPP by substituting on the pyrolidine ring? It'd be cheap and the process would be virtually the same for them. So I came up with some candidates using my limited knowledge of pharmacology & stimulant SARs and some info I found about racetam metabolism (most of which which contain a 2-oxo pyrolidine ring and are fairly non-toxic or so it seems). Here are the ones I could think up:

note: I've just used the a-PVP analog versions, but the idea is the same for MDPV, a-PPP, a-PBP, etc versions.

skeleton: alpha-PVP http://s17.postimg.org/8i79wgvd9/PVP.png
For reference purposes.

Analogs:

2'-oxo-PVP http://s14.postimg.org/w6kxs95mn/PVP_2_oxo.png
aka alpha-(2-oxo)pyrrolidinovalerophenone

3'-oxo-PVP http://s9.postimg.org/b3n8bbi99/PVP_3_oxo.png
I figure this one might not metabolize anything like the 2-oxo above.

PyrroleVP http://s22.postimg.org/sd1dsc4zj/PV_Pyrrole.png

2'-PyrrolineVP http://s14.postimg.org/xh1l9n9vj/PV_2_Pyrroline.png

3'-PyrrolineVP http://s9.postimg.org/fzvggr7sd/PV_3_Pyrroline.png

alpha-(2'-fluoro)PVP http://s16.postimg.org/o6dceh3dv/PVP_2_F.png

alpha-(3'-fluoro)PVP http://s24.postimg.org/fvn97cqyb/PVP_3_F.png

alpha-(2',2'-difluoro)PVP http://s16.postimg.org/qvlx9qd0j/PVP_2_2_DF.png

...and so forth with the fluorine atoms. I imagine, in general, the cost would increase with the number of fluorine atoms added.

IndoleVP http://s15.postimg.org/cv8cdo4qx/PV_Indole.png
This might be getting a little to crazy with the tertiary amino substitution. I expect it wouldn't do much as a psychoactive drug at least at low doses...

2',3'-DihydroindoleVP http://s2.postimg.org/of2b77x9z/PV_2_3_dihydroindole.png
Same as above...

2'-PyrazolineVP http://s13.postimg.org/4xcx3wo9x/PV_2_Pyrazoline.png

AzetidineVP http://s23.postimg.org/81up74lnt/PV_Azetidine.png
AziPV

AzetideneVP http://s27.postimg.org/a3x5vd0n5/PV_Azetidene.png
AzePV

Beta-lactamVP http://s7.postimg.org/ul5rbp7jd/PV_Beta_lactam.png


Does anybody here with some pharmacology knowledge have any thoughts on which of these if any we might see next and if they'll be any good or just an new flood of trash that's a far cry away from their PV parent molecules? And do you figure these would not be better drugs than analogs which are substituted at other parts of the molecule? Also is anyone aware of the any of the above molecules being studied or even existing before?

 

[Wisoi]

Why can't they finally exploit the oxazoline structure? Cathinones and pyrovalerones are so lame.

Hopefully they will. I totally agree with you. For the love of God, bring on the oxazolines, phenmetrazines and coke analogs and everyone will be happier. Even them.

But the reason I ask about the PV's specifically is because:

1. I think the process would be easy for them since the synthetic route is known already to them. So this makes it more likely for this to be something they actually do. I figure.
2. They haven't tried substituting on the pyrrolidine ring yet, but it is a logical thing to do since some of the pyrrolidine-having stimulants are "winners" which made a lot of money for them
3. metabolism might be largely the same for some of these, making the effects similar to said "winners" that were previously known to everyone
4. they need new products, and they'd probably like to have good ones that they can easily and cheaply make. These fit the bill.
5. they're lazy when it comes to drug design and usually with chemistry, so this is a logical leap for them.
6. why waste time on oxazoline R&D when their profit margins from this kind of stuff will be just as good better and R&D will be minimal? (from their perspective)

 

[rave23]

unless we begin to synthesize the compounds by ourselves & this will sadly be a fast lane into jail

Not necessarily. Assume that money is no problem. Start a business, obtain means of legally purchasing chemicals from the suppliers out there, and have at it. Just make doubly sure you're not breaking the laws with anything you're producing. A good good friend of mine has a legitimate business down in the states, he works in pest control. He's got an account with sigma-aldrich, and can obtain virtually anything in their catalog that doesn't require a special license to handle. I am super super super jealous.

In theory, there is nothing stopping you from delving into this, if you stay on the right side of the law. Once you represent a business, a lot of doors open up that you don't posses as an individual.

Of course, the moment you start to do anything with intent of human consumption, you're in big big trouble. Maybe you're a perfumers apprentice? Trying to extract and isolate those very special notes only found in Canadian lavender? Or you're a self-taught chemist that creates ever-expanding combinations of flavour for the growing electronic cigarette market? It's up to you.

Never say you can't.

 

[clubcard]

The effects of pyrophenidone are identical to pyrovalerone. You can vapourize it or snort it. Lasts 45 minutes. We just sat and did in 1g over an evening....