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Possibility of an Arylcyclohexylamine - Barbiturate related drug?

blowjay

Bluelighter
Joined
Jan 7, 2010
Messages
372
So I noticed that a certain anti-eleptic drug had the benzyl group on it and was orally active and the structure was very simple and uncomplicated with nitrogens and carbon and not very much going on size wize and I got bored looking at that and just for funzies clicked on phenobarbital as it was mentioned in the article and I wanted to remember what the strucuture looked like so I pull it up and I notice a nice similarity to methoxetamine.

The dosage ranges between both compounds are not small so I think that this type of modification would possibly create a compound that would be one that could POTENTAILLY be 'safe' to take. Add a carbon and a nitrogen on the phenobarbital ethyl chain and maybe make the phenyl into 3-methoxyphenyl and see what kind of things come out of that.

Hell I am just so intrigued abot the possibilities of playing with barbiturates structures and probably moreso with methoxetamines, what if some carbons were used in place of nitrogens in the barb parts and what if some of the 'ones are turned into methoxy groups? Surely something could be made which would buypass a large amount of legislation and would be active. You would have a hell of a time categorizing such a thing because it wouldn't be an arylcyclohexylamine and once the barb structure is tweaked enough, say removal of a nitrogen or so or maybe the methoxy instead instead of the 'one on part of it, you would have a whole new class that would likely be a hell of a kick in the head.

Speaking of, when the fuck is the chloroxetamine going to come out? I would like to see it propyl instead of ethyl but I just now thought of the chloroxetamine name, I am patenting that shit. That would market like a champ. (for those who are lost methoxetamine with a chlorine instead of methoxy group, I would love to see propyl instead of ethyl but anything would be welcome to me).

Any ideas? Hell of a post I know, just came to me and nobody will likely have an answer as to activity I just saw a bit of a hybrid idea I had to jump on.
 
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As far as OP's go, this flows badly and it took me forever to figure out what you were talking about. You're talking about a 5-phenyl-5-amino barbiturates? Or rather a methylamine, wouldn't want a primary amine, I assume. I don't think it'd have any of the activity you'd want. Maybe it'd have anti cancer properties...
 
Chloroxetamine would probably be a dud, 3-bromo-PCP had very little activity so I'd expect the same from the chloro (well highly decreased activity anyway (possibly an ED50 of 100-200mg?)). The fluoro however stands a good chance of being very active at a similar dose and may have different effects to MXE which I'm fairly interested in. Info comes from here by the way: http://www.bluelight.org/vb/threads/504286-PCP-analogs-(Cumulative)

Also what about a 2-methoxy/fluoro group on the benzene ring? I certainly wouldn't mind a string of 2-methyl compounds coming out, for instance 2-methyl-desoxo-ketamine. Probably less euphoric though, as it would lack some of the opioid activity of K. Maybe add in a cheeky 4-OH group as well to save it. I'm not sure what 2 subs on that ring would do to the potency though.
 
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