I think one of the hot topics/questions among Ecstasy users/researchers is whether or not Ecstasy use is associated with chronic depression. However, this is a complex Q as both genetic and envrionmental factors play a role in clinical depression. The following research study discusses the links between having a genetic vulnerability for depression and the impact of ecstasy use. I think what is interesting here is that it is not chronic ecstasy use per se that may put you at risk for chronic depression, but rather a combo of having the genetic vulnerability and history of chronic excstasy use.
In doing my litertuare review for my research study, I came across this article which was published in March of 2005. Just thought I'd pass on the info If you would like, I will keep posting interesting findings/recent research studies as I come across them. Please let me know if you have any interest in my doing this.
A recent study was conducted by Roiser, J.P., Cook, L.J., Cooper, J.D., Rubinsztein, D.C., and Sahakian, B.J. (2005) which examined the association between ecstasy use and subsequent depression. Specifically, the focus of the research was to assess the contribution of a functional polymorphism in the gene encoding serotonin transporter to changes in emotional processing following chronic ecstasy use. Based upon the results of their study, the authors hypothesize that chronic ecstasy use may cause long-term changes to the serotonin system, and that ecstasy users carrying the s allele may be at particular risk for emotional dysfunction. Therefore, findings suggest that an individual’s risk of developing chronic depression as a result of taking ecstasy depends significantly on one’s genes.
http://ajp.psychiatryonline.org
Association of a Functional Polymorphism in the Serotonin Transporter Gene With Abnormal Emotional Processing in Ecstasy Users. Roiser, Jonathan P.; Cook, Lynnette J.; Cooper, Jason D.; American Journal of Psychiatry, Vol 162(3), Mar 2005. pp. 609-612.