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Bupe Please help! Don't want to withdraw or waste good drugs

Jajo300

Jajo300

Greenlighter
Joined
Jul 2, 2013
Messages
5
Hi everyone. First time posting. Thank you all for your info. It has been most helpful on multible occasions.
I've been taking 30 to 70 mg of oxycodone a day for months. I ran out so I took 4 mg of Suboxone film yesterday & today around 2pm. If I don't take anything for 48 hours will I experience withdrawal & after that 48 hours if I take 30 mg of oxycodone will I get the full effect?
I searched but couldn't find the answer so I apologize if this is a redundant question. Thanks again!
 
If you are psychically dependent of course you will experience withdrawals when the bupe wares off..

And at only 4mg's, 48 hours is plenty of time to wait in order to get the full effect from opiates.

Our search engine here on BL could have answered this in a few seconds as this is been talked about hundreds of times.
 
Sorry I guess I didn't do the search right but thanks so much for your response.

Just to clarify 48 hours is plenty of time to wait for the oxy & 4 mg of bupe will wear off in less than 48 hours.

I took the 2nd 4 mg dose of bupe yesterday so if I take another 4 mg of bupe today & then 24 hours from now when I get my script of oxy filled I should be good to go right?
 
Why do you have to wait days for your script to be filled?

If you want withdrawal advice, it's literally a piece of cake, and like the other dude said good advice has already been posted here to fit the bill.
 
If I could've waited 48 hours without oxy and been fine with that amount of suboxone, and suboxone(ew) at that, I wouldn't have had to deal with Buprenorphine maintenance via doctor in the first place.
 
Also remember your way you take bupe and how much you actually get. So if your taking 4 mg bupe sub you might only have 1.5 to 3.0 mg from that dose and average half life is around 30 ish hours. If you IV then you will most likely have the full 4 mg per dose. IVed will have a faster clearance time than nasal, than sub.

I have found bupe, for me, blocks Oxy from its effects greatly vs H, hydromorphone. No idea why, but I have to be in pretty shitty WDs before I feel oxy's. I also find Oxy to be rather weak compared to the hype it receives, but that's near here not there...
 
^ IV'ing anything more than 1-2mg of bupe is a very large opioid dose, due to the immense increase in bioavailability when IV'ing (~100% BA), while sublingual bupe has about a (~35% BA).

2mg bupe IV = 6 mg bupe sublingual, these two doses are definitely blocking dosages.

Most sub shooters I've read about online use 0.5-1mg per shot maximum, as any more is just blocking the norbuprenoprhine (full mu agonist) from binding to the mu receptors, due to competitive partial agonism by buprenorphine when used at blocking dosages.
 
One would rather have bupe block NOR-bupe, if Norbupe out competed bupe, crossed the BBB better its highly unlikely that wed have it as an opioid. It's works mostly in ones gut and would be very very potent in the lungs causing severe breathing problems. It would not be a very euphoric or fun opioid. Norbupe is not something anyone wants more of.
 
I had to wait to get my script filled because my Dr. gave me 3 scripts of oxy. Each one dated monthly. My next one is due July 4th.

I went ahead & took around 6 mg of bupe film orally earlier around 3pm yesterday along with my usual 150 mg of tramadol. Oral is my usual route for everything but I do snort oxy every now & then.

I've never heard that tramadol could be used to prevent w/d. I will defiantly remember that. Thank you!

So later today (the 4th) around noon I plan on taking 30 mg of oxy & 150 mg of tramadol. I really hope the bupe isn't still blocking by then. Does anyone think I should wait longer?
 
Yes tramadol can cause euphoria and stop WDs, its an atypical opioid that gets converted in your body to M1. Tramadol is the parent compound or prodrug of M1. Tramadol also acts on seratonin(sp) and norep. In doses over 600-800mg per day it can cause seizures mind you.

If you don't want to waste your Oxy I would suggest waiting at least 48 hours since your last dose of bupe or when you really feel ill. I usually can last about 80 hours post last dose of bupe before I'm ill and can feel all effects from other opiates.
 
Ok so on the low end I normally take 30 mg of oxy & 150 mg of tramadol a day. If I ran out of oxy again or if I just wanted to take a break could I just take the 150 mg of Tramadol & not w/d or would it take more than that? I have noticed if I take much more than that I feel kind of shitty the next day but that would still b better than w/d.

If this is possible it would be an ideal setup for me so any info you could give me on this would be greatly appreciated. Thanks again!
 
Jajo300 said:
Ok so on the low end I normally take 30 mg of oxy & 150 mg of tramadol a day. If I ran out of oxy again or if I just wanted to take a break could I just take the 150 mg of Tramadol & not w/d or would it take more than that? I have noticed if I take much more than that I feel kind of shitty the next day but that would still b better than w/d.
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In this case, I would keep your ~150mg tramadol dosage for w/d, but rather, stagger your doses. Tramadol produces the most M1 metabolite (O-Desmethyltramadol via CYP2D6 metabolism) when staggered. In your case, I would take 100mg as a starting dose, then take 25mg (half of a 50 tablet) at t:+30 min (30 min after starting dose), then take 25mg at t:+60min, and another 25mg at t:+1.5 hours; and, if you think you need a bit more to kill the mild 30mg oxy w/d's, then take another 25mg at t:+2hours, making it 200mg total, the most I would recommend anyone to take in one day.

Staggering your doses with tramadol significantly boosts the production of the powerful mu-agonist O-Desmethyltramadol, as not everyone's livers have enough alleles (copies) of the CYP2D6 enzyme to effectively convert the serotonin releasing, NRI, stimulant, prodrug Tramadol in to O-Desmethyltramadol, which largely responsible for tramadol's analgesic, narcotic, and CNS depressing effects.

Another benefit to "staggering" your dosages with tramadol is that you significantly cut down the risk of having a seizure or anxiety attack from a single, large dosage. By spacing out your doses within 20-30 min timeframes, you get more opioid/narcotic (O-Desmethyltramadol) effects rather than an "MDMA-Lite" Serotonin-rush attained from eating large, single, bolus dosages of tram.
 
Thanks so much for that info! When the time comes I'm going to try that.

I have one more question though. Being completely honest with myself the truth is its rare that I only take 30 mg of oxy a day anymore. It's really more like 60 to 80 mg a day. 30 to 40 mg to start the day & then 20 to 40 mg later in the day. Most of it orally but often I will snort 10 mg of the late day dose.

Will 200 mg of tramadol still work for that?
 
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