Piracetam + naltrexone ..complications?

[DexterMeth]

I asked about any possible complications with taking both phenibut and naltrexone, but what about piracetam and naltrexone? I could not find any info on this.

 

[ebola?]

I don't see any clear reason for interactions. There might be some profoundly downstream effect, but if so, it lies beyond our current understanding of opioid, cholinergic, and AMPAnergic transmission.

ebola

 

[raybeez]

This information is taken from the drug monograph, and from personal experience (~2 yr use)

Aside from the obvious interaction with opioids, naltrexone does not affect the pharmacokinetics or pharmacodynamics of any other drug class.

REVIA (naltrexone) has few, if any, intrinsic actions besides its opioid blocking properties. However, it does produce some pupillary constriction, by an unknown mechanism.

It is metabolized by the kidneys, and does not interact with CYP* liver enzymes. Therefore it doesn't affect the metabolism of other drugs.

The activity of naltrexone is believed to be due to both parent and the 6-(beta)-naltrexol metabolite. Both parent drug and metabolites are excreted primarily by the kidney (53% to 79% of the dose)

There is only one contraindication for naltrexone. It is hepatotoxic (damages the liver):

... placebo-controlled studies employing up to five-fold higher doses of REVIA (naltrexone) (up to 300 mg per day) than that recommended for use in opiate receptor blockade have shown that REVIA (naltrexone) causes hepatocellular injury in a substantial proportion of patients exposed at higher doses.

The safety and efficacy of concomitant use of REVIA (naltrexone) and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.

An example of another hepatotoxic drug that should not be mixed with naltrexone is acetominophen/APAP/paracetamol (in high doses).

I couldn't find any evidence of piracetam being heptatoxic. However the related drug levetiracetam appears to have some mild heptatoxicity, especially in patients with pre-existing liver problems. I would therefore recommend avoiding high doses of piracetam while on naltrexone, AND recommend that you not mix the two if you have liver disease/history of hepatitis.

 

[DexterMeth]

^Wow, thank you for that info. I am on Keppra right now actually. I am not on naltrexone, someone else is I was asking for, but many thanks regardless.