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Opioids Physical Harm From Opiates

My opinion to the OP's question is quite simple. At the dosage, which is really quite low in the PM world, I don't believe there would be any physical damage related directly to the medicine, period. If taken properly and at that level, no way. I've been on doses quite a bit higher for PM for decades and I don't believe the "meds" have caused any physical damage and my docs can back me up on that. Just my 2 cents worth.
 
BeachBum4u said:
My opinion to the OP's question is quite simple. At the dosage, which is really quite low in the PM world, I don't believe there would be any physical damage related directly to the medicine, period. If taken properly and at that level, no way. I've been on doses quite a bit higher for PM for decades and I don't believe the "meds" have caused any physical damage and my docs can back me up on that. Just my 2 cents worth.
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Well that's incredibly lucky, good for you though.
 
Surprised nobody has mentioned the fact that opioids are ototoxic. There's even been many threads regarding hearing damage/loss/tinnitus associated with opiate use. From what I recall reading, codeine and it's derivatives are the worst offenders. Overuse of APAP is thought to be a contributor, but not the sole cause as hearing loss has been associated with Methadone, Opium, Heroin, Tramadol, and possibly even Kratom.

There has been two threads in the past two weeks regarding tinnitus and hearing loss associated with kratom. I can attest to the tinnitus, but not hearing loss. I assume opiate related ototoxicity is worse with heavy abusers, but it's still a health problem that's under-discussed. Hearing loss aside, to say daily opioid use comes with no negative health effects rediculous.

Auditory sensitivity in opiate addicts with and without a history of noise exposure.
http://www.ncbi.nlm.nih.gov/pubmed/21959116

Since both opium and noise independently can cause hearing loss, it is important to know the prevalence of hearing loss among individuals who are exposed to opium or both opium and noise.... Fifty percent (2/4) of the individuals without any noise exposure had a hearing loss confirming previous reports that some of the population is vulnerable to the ototoxic effects of opioids.... Health professionals need to be aware of the possible ototoxic effects of opioids, since early detection of hearing loss from opium abuse may lead to cessation of abuse and further progression of hearing loss
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Review of Opioid-Associated Hearing Loss and Possible Mechanism of Opioid-Mediated Endothelin-1-Dependent Cochlear Vasoconstriction. (In full text)
http://scitechnol.com/review-opioid...learvasoconstriction-7aoU.php?article_id=1890

Conclusion:
Opioids are commonly used in the general population for both medical and recreational purposes. Recently, there have been increasing reports documenting opioid-induced, sudden or rapidly-progressive sensorineural hearing loss. These have been attributed to a variety of opioids, including hydrocodone/acetaminophen, heroin, and methadone. Although the mechanism of opioid-induced hearing loss remains unknown, it is likely due to cochlear hypoxia from endothelin-1-mediated vasoconstriction of the spiral modiolar artery. Genetic variations in liver cytochrome P450 genes and the MOR regulatory region may explain why some users experience hearing loss while others do not.
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Hydrocodone Use and Sensorineural Hearing Loss Case Series
http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=10&page=467

The chronic use of hydrocodone can be associated with progressive sen-sorineural hearing loss. Successful auditory rehabilitation can be achieved with cochlear implantation. Genetic polymorphisms of drug metabolizing enzymes as well as associated comorbidities such as hepatitis C infection may be significant in the development of hydrocodone ototoxicity, though additional investigations are necessary.
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Profound hearing loss associated with hydrocodone/acetaminophen abuse.
http://www.ncbi.nlm.nih.gov/pubmed/10733182

CONCLUSIONS:

Hydrocodone is frequently prescribed in combination with acetaminophen for the relief of pain and has a side effects profile similar to other medications in its class. Although not described previously, overuse or abuse can be associated with a rapidly progressive sensorineural hearing loss. These patients can be successfully rehabilitated with cochlear implantation.
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In a deep enough nod you can cause severe muscle damage. I knew a guy who had to have part of his calf cut out from going on the nod and falling asleep in a bad position all night. I also had an old childhood friend I bumped into not long ago after not seeing him for a few years and he had both legs amputated at the knees. He had the same thing happen to him but to a worse extent. Sadly he actually asked if I was holding. Some people will never stop using.
Back to the OP's question, I don't believe it would do any significant harm, but with someone who has health problems it could make them worse. At that dose it's unlikely though.
 
CaptainKratom said:
Surprised nobody has mentioned the fact that opioids are ototoxic. There's even been many threads regarding hearing damage/loss/tinnitus associated with opiate use. From what I recall reading, codeine and it's derivatives are the worst offenders. Overuse of APAP is thought to be a contributor, but not the sole cause as hearing loss has been associated with Methadone, Opium, Heroin, Tramadol, and possibly even Kratom.

There has been two threads in the past two weeks regarding tinnitus and hearing loss associated with kratom. I can attest to the tinnitus, but not hearing loss. I assume opiate related ototoxicity is worse with heavy abusers, but it's still a health problem that's under-discussed. Hearing loss aside, to say daily opioid use comes with no negative health effects rediculous.

Auditory sensitivity in opiate addicts with and without a history of noise exposure.
http://www.ncbi.nlm.nih.gov/pubmed/21959116



Review of Opioid-Associated Hearing Loss and Possible Mechanism of Opioid-Mediated Endothelin-1-Dependent Cochlear Vasoconstriction. (In full text)
http://scitechnol.com/review-opioid...learvasoconstriction-7aoU.php?article_id=1890



Hydrocodone Use and Sensorineural Hearing Loss Case Series
http://www.painphysicianjournal.com/linkout_vw.php?issn=1533-3159&vol=10&page=467



Profound hearing loss associated with hydrocodone/acetaminophen abuse.
http://www.ncbi.nlm.nih.gov/pubmed/10733182
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THIS is what I was looking for, THANK YOU.
Again, I NEVER SAID OPIATES IN REALITY WOULDN'T CAUSE DAMAGE- I AGREE TO SAY THAT WOULD BE RIDICULOUS. I WAS MERELY EXPLORING AN INTRIGUING HYPOTHETICAL.

Damn that's so interesting I gotta look more into that, previously being a heavy user in both kratom, as well as prescription opioids, this definitely grabs my attention. Also curious as to suboxone's relation to this issue. Never heard of this whatsoever before though, so I am skeptical as to how widespread this occurs, like there's no "be a junkie and go deaf" kinda urban street wisdom passed around hahaha

Still, will research more, thanks for bringing it up, exactly what i was looking for by making this thread.
 
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