Gaian Planes said:
I dont understand why you would inject CJC three times a day (and at such a high dose). It stays in your bloodstream/binded to your glands for a long while (like 2+ weeks noticeable after the last dose). So, I dont think a 3x per day protocol is necessary at all.
The CJC-1295 & the total 24 hour dosing of GHRP-6 together comprise a single comparison with exogenic GH administration.
I would not inject CJC 3X a day alone. But, in conjunction with GHRP-6, it makes sense. I believe 2mg a week is optimal for body building, less for anti-aging purposes. You are correct, CJC does bond for a long time, and if I was only to use CJC, I would use it 2X a week.
CJC-1295 is a long-lasting analog of GHRH and therefore only twice a week dosing is needed to keep GH levels elevated. GHRP-6 (all the GHRPs) as soon as they are injected create a 2 hour pulse of GH release.
Administering both GHRP-6 (or any GHRP) and GHRH together synegistically increases that newly created pulse. GHRP-6 creates a big pulse of GH but GHRP-6 + GHRH creates a much bigger pulse of GH.
I can't speak from experience, just from what I have read. Attempting to maximize the total amount of GH release over a 24 hour period I think you would want both GHRH chronically elevated and several GH pulses amplified.
CJC-1295 chronically elevates GHRH without desensitizing or creating a waning GH release profile. This raises the troughs of GH (i.e. GH remains elevated & consequently so does liver-synthesized IGF-1). Elevated levels of IGF-1 have been shown to contribute to growth.
GHRH + GHRPs administered together synergistically amplify a two hour pulse. Pulsation had been determined to be highly necessary for tissue growth. The studies do show that some GHRPs increasingly exert an effect up to about 400mcg (or 4mcg/kg). However adding more than 100mcg (1mcg/kg) of GHRH did not add to the synergy.
Optimally you could dose 100mcg of CJC-1295 w/ 100-400mcg of GHRP in the morning (on an empty stomach 25 minutes before eating); again in the afternoon/PWO; finally just before bed.
That protocol would create a weekly total of CJC-1295 of 2.1 mgs.
There is benefit to adding more CJC-1295 but this will only increase Base GH levels & IGF-1 levels not pulse amplitude. The CJC-1295 clinical trial demonstrated that the CJC-1295 dose (aprox. 2.1 mgs) could be doubled, tripled even quadrupled and exert ever increasing positive elevations of GH & IGF-1 levels.
It doesn't matter how/when you dose the extra CJC-1295 (i.e. you will dose 100mcg 3x per day w/ GHRP and the remaining CJC-1295 as is convenient).
You could administer the extra CJC-1295 w/ the daily CJC/GHRP doses or twice a week in two large doses.
As non-diseased aging adults our pituitary gland continues to possess the ability to secrete large amounts of GH (well above what is youthfully normal). Obviously there is a limit and this limit is arrived at in part by the negative feedback signals. Optimally dosing GHRH (analog CJC-1295) & GHRPs (GHRP-6, GHRP-2, Hexarelin, Ipamorelin) can likely achieve a GH releasing profile similar to and substitute for mid-high level exogenic dosing of Growth Hormone (GH).
GHRP-6 has a finite life in blood plasma. Like all peptides it is subject to enzymatic degradation. Once administered it exerts its effects for a couple of hours before all of the peptide is broken down into amino acids or amino acid "strings" incapable of exerting an effect. They are in effect "digested".
That effect that GHRP-6 exerts is basically "asking the pituitary to release more growth hormone & having the pituitary comply with the request". After GHRP-6 dies, so dies its request.
Or so I've been told.
The above info come from Dat, they are not my own findings.
