• N&PD Moderators: Skorpio

Peptides and neurotransmitters that would add to the reward of rewarding drugs

Psychedelics massively induce glut release, sarcosine and DAA is like taking 5HTP (will do shit compared to releasers). GHB also releases glutamate like amp wich all markedly increase sex pleasure.
If you have sex more than once a week, a more sustainable, less intense supplement level enhancer might well have its place.

Anyway, if it's glutamate we want to target, maybe try some racetams alongside all of the above to potentiate NMDA and AMPA? They're known enhancers of recreational drugs, and piracetam would double as a safeguard against excitotoxicity.

Maybe, I just can't imagine being anhedonic without also being depressed at the same time because of it.
It happens regularly enough, though. The distinction is pretty specific in psychiatric terminology, and I've personally seen people affected by one without the other in action.
 
If you have sex more than once a week, a more sustainable, less intense supplement level enhancer might well have its place.

Anyway, if it's glutamate we want to target, maybe try some racetams alongside all of the above to potentiate NMDA and AMPA? They're known enhancers of recreational drugs, and piracetam would double as a safeguard against excitotoxicity.


It happens regularly enough, though. The distinction is pretty specific in psychiatric terminology, and I've personally seen people affected by one without the other in action.

Racetams never helped me, DAA is a known libido enhancer and did seem to enhance sexual pleasure tough.
 
have you examined the idea that maybe the reason why you are happy yet cant get any pleasure from activities is that you have a personality issue? its possible and would explain the contradictory nature of your attention seeking posts that often don't really make that much sense other than the schema "i think drugs solve problems, therefore i can justify use of them with a medical need for them them". its not like drug companies haven't done that with adhd sofar...
 
You're not an addict so you don't really *need* to be doing this. You also say your mood is relatively stable most of the time. So why start pursuing all this neurochemical fuckery? I just don't get it.

When used long-term, drugs that enhance pleasure tend to cause down-regulation or outright receptor damage. You'll just end up so far below baseline that you're going to be crawling on all fours back to your normal life again. If you can still get enjoyment out of things without drugs then don't fuck with it.

If your life doesn't feel good the change your life, not your brain.
 
GHB + stimulants is pretty much the win for sex.

MDMA actually makes me hornier than any other drug. Actually I haven't taken MDMA for quite a few years because it just makes me want to fuck every attractive female within eyesight. I don't understand how some people can take this drug and just be happy talking about shit.

Meth makes me fairly horny but limp dick so no good there.

I used to do MDPV (or whatever the original tan batch was) and 1,4-BDO ... smoked the PV... fucked till I or the lady passed out first.

Racetams reduce my sex drive. DXM kills it. Ketamine makes it a little kinky. MXE has a paradoxical effect where I love to fuck and perform well but I have just as much fun doing anything else ;)

Hmm what else. Sorry the entire premise of this thread seemed a little rediculous so I'm having a little fun here!
 
have you examined the idea that maybe the reason why you are happy yet cant get any pleasure from activities is that you have a personality issue? its possible and would explain the contradictory nature of your attention seeking posts that often don't really make that much sense other than the schema "i think drugs solve problems, therefore i can justify use of them with a medical need for them them". its not like drug companies haven't done that with adhd sofar...
I justify using drugs because they make me euphoric, i think the whole "oh they help medically so i justify getting high thing" doesnt make any sense at all, all humans (mostly) use recreational substances for recreation, it doesnt make any sense whatsoever.

I really cant see how a personality issue can cause anhedonia, i live my life when anhedonic too but it just feels like torture.

You're not an addict so you don't really *need* to be doing this. You also say your mood is relatively stable most of the time. So why start pursuing all this neurochemical fuckery? I just don't get it.

When used long-term, drugs that enhance pleasure tend to cause down-regulation or outright receptor damage. You'll just end up so far below baseline that you're going to be crawling on all fours back to your normal life again. If you can still get enjoyment out of things without drugs then don't fuck with it.

If your life doesn't feel good the change your life, not your brain.

Anhedonia is unrelated to mood, as you said long term addiction can induce anhedonia and so can antidepressants, if you have anhedonia how could changing your life help? I dont see any reason for that either as i have the life i want, do the same things when im anhedonic as i know its how i wonna live life and i dont feel anhedonic everyday.

Thats the whole point i dont get enjoyment out of anything without drugs, lol that would be quite idiotic to use drugs for anhedonia when you have enjoyment without them, but i suppose its for those that need an excuse to use drugs, like religious ppl not following the rules but justifying it by being good people is maybe related to that.

The reason for that?
Imagine mdpv doesnt enhance sexual pleasure anymore nor delay ejaculation while the full effects and euphoria are still there, thats kinda an example with what i mean how differened things modulate differened aspects of reward.

Maybe its just me but i dont understand why youd need to use a excuse to use drugs, it seems dead obvious that leading a boring life can lead to something like "anhedonia" and its obviously far more convienient if my issue was possible to fix without drugs as id feel not anhedonic all the time, so going to drugs when you dont need to seems stupid too (then id just take them to get high). But seems many individuals lack some common logic so i suppose ppl assume the same for me.
 
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MXE has a paradoxical effect where I love to fuck and perform well but I have just as much fun doing anything else ;)

^ =D

I think the OP's "problem" is also mine, at least to some degree, and i think it's really based on personal indifferences.
 
Foxy is said to be specifically erotic and enhancing sexual feelings as another example.
It is, but it's also... distracting, heavy-ish on the body and mildly anxiogenic. While foxy enhances physical sensations very strongly, it can be tough to get to the point of having sex, and staying there.

Moxy seems to be strictly superior for sexual (and most other) purposes. Less body load, easier on the mood and the single clearest psychedelic aphrodisiac I know about. Too bad Foxy has the cooler name.
 
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