• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards | negrogesic

Pentazocine/nalphubine-nubain (sp)

Ethan-ate

Greenlighter
Joined
Jun 10, 2015
Messages
40
Apologies for any title misspelling....I am trying to use a tablet to type .....A tablet I can't swallow also.

Okay I understand both pentazocine and nubain are related as in weaker morphine derivatives, I've tried bane. ...my only IV experience as I am fine IM or Sub-q after years or steroid jabs but I get queasy as hell hitting my veins....I am aware I could of IM or SUB-Q the bain but I had to try.

It was of course....well I am sure you know. It's strictly a rare treat with my personality but question is .....are nalphubine-nubain and pentazocine similar in strength....halflife.....High etc and on a 1-10 how far are they from injectable morphine. Hypocritically enough I only indulge pharmacy stuff from steroids to stims to opiates so I'd like some feedback.

Cheers
 
Last edited:
Nalbuphine is much more potent then Pentazocine which is about a step up from Codeine though less people tend to like it. 10mg's of Nalbuphine given by injection (IV, IM, SC) is going by 1 chart anyway about equal to 10mg's of Morphine given via injection. As for Pentazocine about 90-100mg's given orally is about equal to 10mg's of Morphine given by injection. If you have the injectable kind of Pentazocine about 60mg's given via injection is equal to about 10mg's of Morphine given via injection. Do not IV the tablets as most of the pills in America are the Talwin NX kind which have Naloxone in them to block the effect of the Pentazocine. The pills in Canada do not but they may have some rather nasty binders in them. It would also be worth noting that Talwin can be dodgy to inject even if you have the ampules made for injection as it can sometimes cause injection site necrosis leading to limb amputation in some cases. While Talwin ampules are still on the market in Canada i have never heard of it being used in a hospital setting at all.

You aren't going to get typical opiate like effects like you would from typical Mu agonists like Morphine, Heroin, Dilaudid, Oxycodone, etc. I only know 1 person who has taken Talwin and they reported feeling very disoriented at times and that it was far more dreamy then usual opioids. As these mixed antagonists/agonists act on the Kappa receptor they can feel alot like Salvia to some people except not nearly as strong as Salvia is a much more potent Kappa agonist. These drugs typically have far less abuse potential then Mu agonists and drugs like Pentazocine reportedly have even less abuse potential for most people then Codeine does. Some people get alot of dysphoria from these opioids which is one reason why they aren't used much anymore.
 
They are both agonists at the kappa receptor and antagonists at the Mu receptor. That is the opposite of what you want when it comes to the classic opiate euphoria. Essentially one could think of these two drugs as being similar to using bupe recreationally, except even shittier.

When compared to IV morphine:
Pentazocine: 0/10
Nalbuphine: 1/10


Also, the analgesic equivalencies that android posted are correct, but take those with a grain of salt because they don't translate directly to actual effects. If that were the case, that would mean 10mg of nalbuphine is like taking 20mg oxy orally, and that's not the case at all. Even codeine is a step up from both of these because it actually metabolizes into a true opiate - morphine. Talwin gained a little fame but only during times when heroin wasn't available, and this was also in the 70s, long before oxycodone came along and blew all that crap out of the water. Another interesting tidbit is that only 1 isomer of pentazocine is the kappa opiate, while the other isomer is completely devoid of any opioid activity and acts as an NMDA antagonist if I remember correctly. That being said, I guess you could find the atypical opioids (Pentazocine, tramadol, propoxyphene, Stadol) somewhat enjoyable if haven't ever really used a full mu-agonist. For the most part, the four I listed are generally really crappy drugs.
 
Last edited:
Tramadol and (Dextro)Propoxyphene (Darvon, Darvocet the kind with Acetaminophen/Paracetamol added to them) are Mu agonists not Kappa Agonists if i remember right. Tramadol's active metabolite O-desmethyltramadol does have a higher affinity for both the Delta and Kappa receptors then Tramadol does but it still acts primarily as a Mu agonist i believe. This is in addition to Tramadol acting as a SNRI which is what i mostly seem to get from the junk. (Dextro)Propoxyphene has been taken off the market for a few years in most of the world because of it's very toxic effects that have nothing to do with it's very mild Opioid effects. It is primarily a Mu agonist with very weak action on that site.

Butorphanol on the other hand exerts most of it's analgesic effects through it's Kappa agonist as it is a mixed antagonist/agonist effects on the Mu receptor. It's still used abit in the form of a nasal spray for migraines (it's long since gone generic here and they no longer have brand name Stadol in Canada) but unless your doctor for some reason prefers to use this drug (some doctors are just comfortable prescribing what they know and have been using for awile) or if the more commonly used Mu agonist drugs such as Codeine, Demerol (meperidine/Pethidine), oxycodone, etc don't work or aren't tolerated by the patient other Opioids like Codeine, Fiorinal-C's/Fioricet-C's (Aspirin or Acetaminophen/Paracetamol with Butalbital, caffeine and Codeine) Oxycodone or Demerol (which although it's fallen out of favor is still used for a few purposes one of which is migraines) is preferred or even Morphine usually with a anti-emetic for acute relief. Here if you show up puking from a Migraine they will usually give you a shot of Demerol with a anti-emetic such as Dimenhydrinate or Prochlorperazine or even Chlorpromazine. If they are feeling really generous they will give you Morphine with a anti-emetic. I do know one person who was prescribed Talwin for migraines but i am going to bet this is because their doctor has been around for ages and for some reason prefers Talwin over more common Opioids for treating migraine like headaches.

Drugs like Pentazocine, Butophanol, and Nalbuphine are REAL Opioid's they just don't have typical opiate effects like Morphine and other Mu agonists due to their affinity for the Kappa receptor. Kappa Opioid's do work well for some people and for some reason work better in women and red heads in particular. They have fallen out of favor among most doctors because of the side effects of dysphoria and sometimes hallucinations and also because they tend not to be great analgesics and also because you can't use them in patients who are dependent on Mu agonist Opioids. Talwin was popular in some places in the T's and blues combo where they mixed the anti-histamine tripelennamine with Talwin and injected the combo. Another popular combo in certain places like the Canadian prairies and other parts where it can be hard to get Heroin or decent script Opioids was T's and R's which is Talwin mixed with Ritalin. This was usually injected for a sort of poor mans speedball though i seriously doubt combing Talwin with a shitty stimulant like Methylphenidate would produce effects anywhere near as good as say a Heroin and Coke or Dilaudid or Morphine and Coke speedball. Of course you can't inject any Talwin pills made in the US as they are all Talwin NX which have Naloxone in them. They never did add Narcan to Talwin in Canada as i doubt it was popular except in a few small isolated towns. I have never seen it anywhere though my ex did call me up the night she took abunch of Talwin pills orally and she sounded like she was having a good time. She was not tolerant to Opioid's at all at the time and described Pentazocine as being alot more spacey, dreamlike and disorienting then Oxycodone was. She liked it alot but had she actually been addicted to Opioids she would have been driven right into precipitated withdrawal the same as you would be with other mixed antagonists/agonists.
 
Tramadol and (Dextro)Propoxyphene (Darvon, Darvocet the kind with Acetaminophen/Paracetamol added to them) are Mu agonists not Kappa Agonists if i remember right. Tramadol's active metabolite O-desmethyltramadol does have a higher affinity for both the Delta and Kappa receptors then Tramadol does but it still acts primarily as a Mu agonist i believe. This is in addition to Tramadol acting as a SNRI which is what i mostly seem to get from the junk. (Dextro)Propoxyphene has been taken off the market for a few years in most of the world because of it's very toxic effects that have nothing to do with it's very mild Opioid effects. It is primarily a Mu agonist with very weak action on that site.

Butorphanol on the other hand exerts most of it's analgesic effects through it's Kappa agonist as it is a mixed antagonist/agonist effects on the Mu receptor. It's still used abit in the form of a nasal spray for migraines (it's long since gone generic here and they no longer have brand name Stadol in Canada) but unless your doctor for some reason prefers to use this drug (some doctors are just comfortable prescribing what they know and have been using for awile) or if the more commonly used Mu agonist drugs such as Codeine, Demerol (meperidine/Pethidine), oxycodone, etc don't work or aren't tolerated by the patient other Opioids like Codeine, Fiorinal-C's/Fioricet-C's (Aspirin or Acetaminophen/Paracetamol with Butalbital, caffeine and Codeine) Oxycodone or Demerol (which although it's fallen out of favor is still used for a few purposes one of which is migraines) is preferred or even Morphine usually with a anti-emetic for acute relief. Here if you show up puking from a Migraine they will usually give you a shot of Demerol with a anti-emetic such as Dimenhydrinate or Prochlorperazine or even Chlorpromazine. If they are feeling really generous they will give you Morphine with a anti-emetic. I do know one person who was prescribed Talwin for migraines but i am going to bet this is because their doctor has been around for ages and for some reason prefers Talwin over more common Opioids for treating migraine like headaches.

Drugs like Pentazocine, Butophanol, and Nalbuphine are REAL Opioid's they just don't have typical opiate effects like Morphine and other Mu agonists due to their affinity for the Kappa receptor. Kappa Opioid's do work well for some people and for some reason work better in women and red heads in particular. They have fallen out of favor among most doctors because of the side effects of dysphoria and sometimes hallucinations and also because they tend not to be great analgesics and also because you can't use them in patients who are dependent on Mu agonist Opioids. Talwin was popular in some places in the T's and blues combo where they mixed the anti-histamine tripelennamine with Talwin and injected the combo. Another popular combo in certain places like the Canadian prairies and other parts where it can be hard to get Heroin or decent script Opioids was T's and R's which is Talwin mixed with Ritalin. This was usually injected for a sort of poor mans speedball though i seriously doubt combing Talwin with a shitty stimulant like Methylphenidate would produce effects anywhere near as good as say a Heroin and Coke or Dilaudid or Morphine and Coke speedball. Of course you can't inject any Talwin pills made in the US as they are all Talwin NX which have Naloxone in them. They never did add Narcan to Talwin in Canada as i doubt it was popular except in a few small isolated towns. I have never seen it anywhere though my ex did call me up the night she took abunch of Talwin pills orally and she sounded like she was having a good time. She was not tolerant to Opioid's at all at the time and described Pentazocine as being alot more spacey, dreamlike and disorienting then Oxycodone was. She liked it alot but had she actually been addicted to Opioids she would have been driven right into precipitated withdrawal the same as you would be with other mixed antagonists/agonists.

Yes you are correct, tramadol and darvocet are indeed Mu acting. I guess I meant to group them into the 'chemical opioid' category so to speak since they are synthesized without any opiate pre-cursors. Drugs like that tend to be very problematic with how they work in the body. From what I've read, darvocet caused QT prolongation due to being a Na channel blocker and tram just causes seizures without any warning.

Interesting about how they do it in canada. Here in the states a trip to ER for a migraine isn't very likely to yield anything but some NSAIDS and a shot of phenergan. It depends on the hospital but I know that for the most part IV dilaudid is the standard opiate for trauma injuries and such, while Nubain is reserved only for labor. The US actually quit making and marketing the shit pretty recently and I think it's been replaced with butorphanol.

I think most of the problem you mentioned has to do with what is commonly available. Kinda like how IV buprenorphine is the drug of choice for users in India. Those atypicals listed will have effects but they won't be enjoyable if even tolerable. Demerol could also fall in this category, but it's actually highly lipid soluble and binds pretty well to the Mu receptor which really does give it more of an opiate high. As far as human physiology is concerned I think that demerol may even be more chemically addictive than morphine since it's also selective for DAT and SERT. Ethan-ate if using uncommon opioids just to say you did them is your knack then I'd probably try to score some of this or some prescription laudanum syrup or something. Leave all that pakistani counterfeit online garbage alone. It's no good.
 
Top