Psychestim
Bluelighter
- Joined
- Feb 8, 2021
- Messages
- 447
Preface:
PCiPr is a novel dissociative of the arylcyclohexylamine family known for its wide array of powerful effects on the human mind and body. Of all the available dissociatives on the RC market the N-isopropyl substitution hasn’t been explored nearly as much as the N-methyl, N-ethyl or N-piperidinyl substituted ACH’s. The only one I can think of is MXiPr (3-MeO-2’-Oxo-PCiPr) which was introduced alongside MXPr as an MXE replacement a couple years ago. The N-iPr substitution is capable of producing highly potent and fascinating compounds so further exploration is needed.
According to a 1982 paper from R. E. Solomon, et. al. PCiPr was the second most potent dissociative substituting for ketamine in trained rhesus monkeys after PCE.¹ Despite the greater potency in animals and humans, PCE has slightly lower affinity at the NMDAr PCP site relative to PCP (62 vs 35 nM using [3H]-MK-801)²,³ implicating pharmacokinetic factors in the increased potency. A study in mice reporting greater CNS penetration of PCE than PCP supports this observation² and is significant for in vivo studies involving arylcycloalkylamines. PCiPr was found to have a relative potency of 2.55 compared to PCP, indicating it may be more potent in rats than in rhesus monkeys.⁴ Supporting the in vivo animal data, PCiPr might be slightly more potent than PCP in humans.
Spoiler alert, PCiPr is less potent than PCP, and PCE in humans granted still very potent and long-lasting.
Background information:
- sex: male
- age: 26
- weight: 78 kg
- prior disso experience: N2O, 3-Me-PCPy, 3-Me-PCiPr, 3-Cl-PCP, 3-HO-PCP, 3-MeO-PCP, 3-MeO-PCE, DMXE, MXPr, MXiPr, MXE, O-PCE, PCP, PCE, FXE, DCK, 2-FDCK, Ketamine, DXM, Memantine
- setting: bed in Airbnb, alone
- set: This experience took place a little over three months ago when I traveled the US for two months. It was a challenging trip altogether but made me grow a lot as a person. The difficulties I faced during this time perioid were catalysts for change in my life and everything that followed was necessary. This trip happened a few days prior to my 3-MeO-PCsBu experience (I wrote about it [here](https://www.reddit.com/r/researchchemicals/s/71NDYDkOjE)) so my mental state was very similar to how I described it there.
- tolerance: I have dabbled with other drugs the last couple days incl. a bump of PCP four days prior with two new friends and 15mg 3-Me-PCiPr (p.o.) alone the day after that. Not much to say about the PCP itself other than that I really liked it in a social setting and that it was a short and fun experience. 3-Me-PCiPr is not the focus of the report either but I’ll go into it quickly as there is no information on it as well. The person who gave it to me mentioned it wasn‘t really to their liking, and others who tried it shared the same opinion. All of the individuals who sampled it though insufflated the material and reported severe pain which is why I opted to take it by mouth. It came on rather quickly and I was pleasantly surprised by how euphoric and clearheaded it made me feel. The dissociation at that dose was moderate and I could’ve certainly taken more but as no one tried it p.o. before it was only responsible to not take more than that. Physically it was stimulating but not to a degree that it ever became uncomfortable and it was way less numbing than a comparable dose of 3-MeO-PCP. The warmth and euphoria were much less intense than, for example, MXE or the first half of a strong dose of MXPr. It might be comparable to an oral dose of MXiPr but who knows how larger doses might affect the euphoria. I can’t remember how long the duration was exactly but I think it was shorter than I expected. Before these two experiences I barely used any dissociatives for a couple months so I basically had no tolerance.
PCiPr.HCl (15mg, intranasal) / Trip Report:
No substances were consumed prior to this experience, except for a cup of coffee in the morning and I ate a light meal an hour before taking the substance.
T:00:00:
I crush the crystalline PCiPr salt on my laptop using my driver's license and gently insufflate it with the help of a paper straw. To my surprise, it hardly burns and the initial taste is tolerable.
T:00:30:
The drip tastes slightly sweet, but is still disgusting. I don't feel sick but it almost makes me gag a few times as the drip lingers in the back of my throat for a long time.
Having not left the apartment today, I feel like a hermit. I‘m in a gloomy mood, today is a pretty gray day where everything seems hopeless and meaningless.
T:01:00:
I start to notice a slight dizziness and light-headedness. A cold sensation spreads through my body. I try to type something on my laptop but it becomes increasingly difficult to focus. The PCiPr is kicking in, it feels like the calm before the storm. The dosage makes me slightly nervous as I've just blindly trusted someone else's information and jumped right into it. Well, too late now. It’s comforting that related substances are so safe even at ridiculously high doses. I distract myself by watching YT videos, my vision is getting blurrier but the rise of the intensity is slow and steady.
T:02:30:
The effects are getting stronger and stronger, the dosage is certainly in the moderate-high range. I have a greatly altered perception of my surroundings and I feel very introverted. The headspace is profound and confusing, pulling me into introspective thoughts about my current place in life and my future. Not too happy with life at the moment. It's been more than three weeks since I flew from home to the US and it feels so much longer. I've been denied work at the university because of a visa-related issue, the health of my grandma is rapidly declining, my cat just died and I'm strongly considering ending my long-term relationship. My self-worth isn’t the greatest either. I'm watching a lot of videos on how to feel better about myself and how to become the best version of myself. Why do I force myself to watch videos like this and put even more pressure on me. Why can’t I just be happy with who I am. A reccuring theme that I know all too well by now but it still follows me. I desperately need change.
T:04:00:
I am strongly dissociated and also quite stimulated, which is not unusual for these substances. What surprises me, however, is how profound it is. PCE is more superficial in comparison, and I feel like PCP might be too but I have too little experience with it to say for certain. I guess I can’t attribute the profundity of the experience entirely to the substance, but the 3-Me-PCiPr wasn’t nearly as introspective. I feel completely entangled. A veil of cold numbness envelops me and yet gives me a feeling of security. I am lying there on my bed detached from emotion yet feeling so much. Doing nothing but it‘s overwhelming. Not literally but figuratively.
T:06:30:
The things that I thought about before are now just noise. The deepness has dissipated a bit but I am still very much in the experience. No sign of it stopping anytime soon but the effects plateaued. Apart from memantine, this is the longest lasting dissociative I’ve tried.
I switch between doing absolutely nothing to browsing on my laptop without a purpose which also equates to doing nothing. Anyway what else is there to do in this state.
I put on some melancholic music and look at pictures of my cat. Not as sad as I thought it would be!
T:09:00:
I try to get myself to sleep, but I'm still heavily impaired which makes that difficult. I lie in bed for what feels like eternity, tossing and turning from side to side until I get up, annoyed, and place 1mg of clonazepam under my tongue. I also take a few puffs from my Δ9-THC pen. Fall asleep shortly after.
The day after:
T:15:00:
I wake up after an unrestful night, dizzy and unwell. My stomach is queasy and my balance is off. I try to force myself to eat, but I give up after a piece of bread and a few tomatoes. Instant coffee will have to help me survive for the next few hours.
T:22:00:
Have been hanging around a famous US university campus for the last couple hours trying to work on my thesis but I wasn’t really productive. I still feel off. My head is dull and I don’t care about anything really. Started a conversation with a random girl and went out to eat lunch with her so at least socially I managed to retain some basic skills. Went about my day after that and relaxed.
—————————————————————————
Conclusion:
Evidently it was a powerful and introspective experience. PCiPr is a long-lasting arylcyclohexylamine with great depth and a lot of character. A colossus of a dissociative and a must-try for any true dissonaut. Can‘t see myself using this frequently or in much higher doses, especially if I‘m unprepared or in a bad mental state but as an occasional earthquake I do see potential.
3-MeO-PCiPr (only tried at low dose) is a fruitful follow-up but very much unlike base PCiPr. Which I find surprising considering PCP and PCE share many similarities with their 3-MeO counterparts. 3-Me-PCiPr, which I described in the tolerance section above, is also very different from base PCiPr. Another PCiPr derivative I have yet to test is 3,4-MD-PCiPr. Once I have sampled all of the MD-PCx in my collection I want to work on a post that compares them all because there is very limited information about them and I feel like they could be interesting.
On a side-note this experience was a small piece of a puzzle and a contributing factor to many changes that followed. I am in a much better place right now and rereading/editing this report was cathartic in itself.
Keep your heads up!
Psychestim
Sources:
1. R. E. Solomon, et. al. / Discriminative stimulus effects of N-substituted analogs of phencyclidine in rhesus monkeys
2. A. P. Kozikowski, et. al. / Structural determinants of affinity for the phencyclidine binding site of the N-methyl-D-aspartate receptor complex: Discovery of a rigid phencyclidine analogue of high binding affinity
3. A. Kalir, et. al. / Structure-activity relationship of some phencyclidine derivatives: in vivo studies in mice
4. E. J. Cone, et. al. / Structure-activity relationship studies of phencyclidine derivatives in rats
PCiPr is a novel dissociative of the arylcyclohexylamine family known for its wide array of powerful effects on the human mind and body. Of all the available dissociatives on the RC market the N-isopropyl substitution hasn’t been explored nearly as much as the N-methyl, N-ethyl or N-piperidinyl substituted ACH’s. The only one I can think of is MXiPr (3-MeO-2’-Oxo-PCiPr) which was introduced alongside MXPr as an MXE replacement a couple years ago. The N-iPr substitution is capable of producing highly potent and fascinating compounds so further exploration is needed.
According to a 1982 paper from R. E. Solomon, et. al. PCiPr was the second most potent dissociative substituting for ketamine in trained rhesus monkeys after PCE.¹ Despite the greater potency in animals and humans, PCE has slightly lower affinity at the NMDAr PCP site relative to PCP (62 vs 35 nM using [3H]-MK-801)²,³ implicating pharmacokinetic factors in the increased potency. A study in mice reporting greater CNS penetration of PCE than PCP supports this observation² and is significant for in vivo studies involving arylcycloalkylamines. PCiPr was found to have a relative potency of 2.55 compared to PCP, indicating it may be more potent in rats than in rhesus monkeys.⁴ Supporting the in vivo animal data, PCiPr might be slightly more potent than PCP in humans.
Spoiler alert, PCiPr is less potent than PCP, and PCE in humans granted still very potent and long-lasting.
Background information:
- sex: male
- age: 26
- weight: 78 kg
- prior disso experience: N2O, 3-Me-PCPy, 3-Me-PCiPr, 3-Cl-PCP, 3-HO-PCP, 3-MeO-PCP, 3-MeO-PCE, DMXE, MXPr, MXiPr, MXE, O-PCE, PCP, PCE, FXE, DCK, 2-FDCK, Ketamine, DXM, Memantine
- setting: bed in Airbnb, alone
- set: This experience took place a little over three months ago when I traveled the US for two months. It was a challenging trip altogether but made me grow a lot as a person. The difficulties I faced during this time perioid were catalysts for change in my life and everything that followed was necessary. This trip happened a few days prior to my 3-MeO-PCsBu experience (I wrote about it [here](https://www.reddit.com/r/researchchemicals/s/71NDYDkOjE)) so my mental state was very similar to how I described it there.
- tolerance: I have dabbled with other drugs the last couple days incl. a bump of PCP four days prior with two new friends and 15mg 3-Me-PCiPr (p.o.) alone the day after that. Not much to say about the PCP itself other than that I really liked it in a social setting and that it was a short and fun experience. 3-Me-PCiPr is not the focus of the report either but I’ll go into it quickly as there is no information on it as well. The person who gave it to me mentioned it wasn‘t really to their liking, and others who tried it shared the same opinion. All of the individuals who sampled it though insufflated the material and reported severe pain which is why I opted to take it by mouth. It came on rather quickly and I was pleasantly surprised by how euphoric and clearheaded it made me feel. The dissociation at that dose was moderate and I could’ve certainly taken more but as no one tried it p.o. before it was only responsible to not take more than that. Physically it was stimulating but not to a degree that it ever became uncomfortable and it was way less numbing than a comparable dose of 3-MeO-PCP. The warmth and euphoria were much less intense than, for example, MXE or the first half of a strong dose of MXPr. It might be comparable to an oral dose of MXiPr but who knows how larger doses might affect the euphoria. I can’t remember how long the duration was exactly but I think it was shorter than I expected. Before these two experiences I barely used any dissociatives for a couple months so I basically had no tolerance.
PCiPr.HCl (15mg, intranasal) / Trip Report:
No substances were consumed prior to this experience, except for a cup of coffee in the morning and I ate a light meal an hour before taking the substance.
T:00:00:
I crush the crystalline PCiPr salt on my laptop using my driver's license and gently insufflate it with the help of a paper straw. To my surprise, it hardly burns and the initial taste is tolerable.
T:00:30:
The drip tastes slightly sweet, but is still disgusting. I don't feel sick but it almost makes me gag a few times as the drip lingers in the back of my throat for a long time.
Having not left the apartment today, I feel like a hermit. I‘m in a gloomy mood, today is a pretty gray day where everything seems hopeless and meaningless.
T:01:00:
I start to notice a slight dizziness and light-headedness. A cold sensation spreads through my body. I try to type something on my laptop but it becomes increasingly difficult to focus. The PCiPr is kicking in, it feels like the calm before the storm. The dosage makes me slightly nervous as I've just blindly trusted someone else's information and jumped right into it. Well, too late now. It’s comforting that related substances are so safe even at ridiculously high doses. I distract myself by watching YT videos, my vision is getting blurrier but the rise of the intensity is slow and steady.
T:02:30:
The effects are getting stronger and stronger, the dosage is certainly in the moderate-high range. I have a greatly altered perception of my surroundings and I feel very introverted. The headspace is profound and confusing, pulling me into introspective thoughts about my current place in life and my future. Not too happy with life at the moment. It's been more than three weeks since I flew from home to the US and it feels so much longer. I've been denied work at the university because of a visa-related issue, the health of my grandma is rapidly declining, my cat just died and I'm strongly considering ending my long-term relationship. My self-worth isn’t the greatest either. I'm watching a lot of videos on how to feel better about myself and how to become the best version of myself. Why do I force myself to watch videos like this and put even more pressure on me. Why can’t I just be happy with who I am. A reccuring theme that I know all too well by now but it still follows me. I desperately need change.
T:04:00:
I am strongly dissociated and also quite stimulated, which is not unusual for these substances. What surprises me, however, is how profound it is. PCE is more superficial in comparison, and I feel like PCP might be too but I have too little experience with it to say for certain. I guess I can’t attribute the profundity of the experience entirely to the substance, but the 3-Me-PCiPr wasn’t nearly as introspective. I feel completely entangled. A veil of cold numbness envelops me and yet gives me a feeling of security. I am lying there on my bed detached from emotion yet feeling so much. Doing nothing but it‘s overwhelming. Not literally but figuratively.
T:06:30:
The things that I thought about before are now just noise. The deepness has dissipated a bit but I am still very much in the experience. No sign of it stopping anytime soon but the effects plateaued. Apart from memantine, this is the longest lasting dissociative I’ve tried.
I switch between doing absolutely nothing to browsing on my laptop without a purpose which also equates to doing nothing. Anyway what else is there to do in this state.
I put on some melancholic music and look at pictures of my cat. Not as sad as I thought it would be!
T:09:00:
I try to get myself to sleep, but I'm still heavily impaired which makes that difficult. I lie in bed for what feels like eternity, tossing and turning from side to side until I get up, annoyed, and place 1mg of clonazepam under my tongue. I also take a few puffs from my Δ9-THC pen. Fall asleep shortly after.
The day after:
T:15:00:
I wake up after an unrestful night, dizzy and unwell. My stomach is queasy and my balance is off. I try to force myself to eat, but I give up after a piece of bread and a few tomatoes. Instant coffee will have to help me survive for the next few hours.
T:22:00:
Have been hanging around a famous US university campus for the last couple hours trying to work on my thesis but I wasn’t really productive. I still feel off. My head is dull and I don’t care about anything really. Started a conversation with a random girl and went out to eat lunch with her so at least socially I managed to retain some basic skills. Went about my day after that and relaxed.
—————————————————————————
Conclusion:
Evidently it was a powerful and introspective experience. PCiPr is a long-lasting arylcyclohexylamine with great depth and a lot of character. A colossus of a dissociative and a must-try for any true dissonaut. Can‘t see myself using this frequently or in much higher doses, especially if I‘m unprepared or in a bad mental state but as an occasional earthquake I do see potential.
3-MeO-PCiPr (only tried at low dose) is a fruitful follow-up but very much unlike base PCiPr. Which I find surprising considering PCP and PCE share many similarities with their 3-MeO counterparts. 3-Me-PCiPr, which I described in the tolerance section above, is also very different from base PCiPr. Another PCiPr derivative I have yet to test is 3,4-MD-PCiPr. Once I have sampled all of the MD-PCx in my collection I want to work on a post that compares them all because there is very limited information about them and I feel like they could be interesting.
On a side-note this experience was a small piece of a puzzle and a contributing factor to many changes that followed. I am in a much better place right now and rereading/editing this report was cathartic in itself.
Keep your heads up!
Psychestim
Sources:
1. R. E. Solomon, et. al. / Discriminative stimulus effects of N-substituted analogs of phencyclidine in rhesus monkeys
2. A. P. Kozikowski, et. al. / Structural determinants of affinity for the phencyclidine binding site of the N-methyl-D-aspartate receptor complex: Discovery of a rigid phencyclidine analogue of high binding affinity
3. A. Kalir, et. al. / Structure-activity relationship of some phencyclidine derivatives: in vivo studies in mice
4. E. J. Cone, et. al. / Structure-activity relationship studies of phencyclidine derivatives in rats
Last edited:
