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Oxytocin + MDMA = ?

nAON

nAON

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Yes please.
I'll fill this post up with big fancy citations later, but for now i'll keep it short.
Oxytocin is widely thought to be involved in bonding, emotion, etc. and is thought to be released by MDMA. Oxytocin is available in pure form (i've mostly seen it as nasal spray), though apparently just taking it by itself doesn't do much. So I thought - what if someone took some of it while rolling on MD? What would the effects be, if any?
 
Ive actually thought about this myself. Can't seem to find anything on it though. If anyone has info on this i would love to read about it.
 
Nothing, oxytocin is almost totally inactive in normal people though some with autism spectrum disorders do get a mild effect. It's got poor dose kinetics anyway.

Even if there was an effect it would be drowned out by the natural release of serotonin and other peptides like oxytocin.
 
I was wondering where you get that oxytocin? And can you also tell me about oxytocins half life which is 3 minutes, how it can bring you positive effects?
 
What do you mean, where you get that oxytocin? It's synthesized in the brain like all other neuropeptides. Just because it has a short half life does not mean it is devoid of activity - look at endorphin - but it does mean it functions poorly as a drug.
 
I'm told that a few squirts of intranasal oxytocin at the peak of an MDMA experience produces a small but significant increase in the empathogenic effects, for perhaps half an hour or so. But this is second hand, I didn't try it myself.
 
I doubt it dude, plus if you are on a working dose of MDMA do you really think you would notice something small like that? The ratio of chemicals MDMA is releasing at once compared to that squirt of oxytocin spray is not able to be compared. Your already feeling brilliant from the MDMA, it would just be placebo imo.
 
My way of thinking was that, sure, MDMA acts on a lot of receptors, but it still has the unique empathy effect that isn't seen in similar stimulants (which would be acting on almost the same receptors as MDMA does). So i'm trying to systematically figure out which ones are involved with the empathy, with oxytocin being chief candidate.

mad_scientist said:
I'm told that a few squirts of intranasal oxytocin at the peak of an MDMA experience produces a small but significant increase in the empathogenic effects, for perhaps half an hour or so. But this is second hand, I didn't try it myself.
Click to expand...

That's good to hear. Certainly something I would wanna try, once I got the spare cash to pay for a bottle of oxytc
 
sekio said:
Nothing, oxytocin is almost totally inactive in normal people though some with autism spectrum disorders do get a mild effect. It's got poor dose kinetics anyway.

Even if there was an effect it would be drowned out by the natural release of serotonin and other peptides like oxytocin.
Click to expand...

Sekio just stop it already.

Have you taken oxytocin yourself? I didn't think so. You have no clue.

I posted a few years ago, on this very website, my own trials of oxytocin administered nasally while on MDMA. I think it does have an effect when you are sober and it is slightly different on MDMA, probably due to a unique synergism between what the drugs do.

That is not to say it is worth a lot to go after, but it is there. The biggest problem with oxytocin is that it also activates vasopressin receptors, which causes diuresis (ie, you have trouble peeing). This can be particularly problematic because MDMA already does this, so you may not pee for a quite a while after doing both.

This is assuming what you purchase is good quality oxytocin though. I wouldn't mess with 95% of what is probably available for sale. There is probably one or two reputable peptide suppliers that will give you something worth using. Please don't buy just anything from a cheap sale website. If they are advertising it as an antidepressant or whatever, don't buy from them. Only buy from a site that sells other peptides, and is clearly not in it just for oxytocin sales but has an actual peptide business going.

I also took it sober and notice effects on memory retention, particularly related to facial recall (as has been widely published) and the same diuresis. It also made me tired.

You can get a good head rush from it when done in the middle of an MDMA experience, but like I said, the bad effects outweigh the good really. Search for my old thread on it in the experiences forum, if it wasn't deleted... it was at least 3 years ago.
 
@Psych - I know that, taken by itself, it will do little or nothing. And the 'you haven't taken it so you cannot talk about it' seems a bit of an odd approach in a forum that advocates learning and harm reduction :P

Will take a look about for your thread, direct experiences are one thing i'm lacking info on
 
No I think it is more than that. If someone is going to post that oxytocin does nothing, when there is plenty of legitimate scientific evidence to support that it does a lot more than nothing, then I would expect them at the very least to have done it themselves and actually experienced that it truly does nothing firsthand.

Learning and harm reduction mean nothing when what is being "taught" is purely here say or guessing.

Oxytocin does a number of things to the brain and body, whether you are sober or on MDMA. Type "oxytocin" or "oxytocin human" into pubmed, hit search and see what kind of studies in humans show up. There are a lot.

The key to getting at these effects is to (1) ensure what you have is really oxytocin and (2) make sure your nose is nice and clear and you have a good quality spray mister combined with good sniffing technique to make sure you sniff the spray up your nose adequately so it doesn't just all drip back down your throat.

Sure it is not the most effective process, and oxytocin can be degraded rather quickly, but this does not automatically mean it will not do anything. Most peptides only need to be active for a few minutes to elicit significant biological effects anyways.

What you may consider to be "little or nothing" may actually be quite a bit if you know what subjective effects to look for.
 
Aha, I misread your post, I thought you were quoting me and saying that since I haven't tried it I just shouldn't bother researching it :P

But yeah, what i'm trying to do is isolate what the actual chemicals, receptors etc. that make MDMA stand out with its empathy effect, and more to the point, how to use those chemicals to potentate the experience. Probably need to read up some more on my end :D

The oxytc source I was looking at is fairly reliable, i'll have to check price but I remember it being fairly expensive, about £30-40 a bottle
 
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