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Oxaflozane - interesting analog of phenmetrazine

wungchow

wungchow

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Looks like an older-generation antidepressant. I can't find much about the pharmacology but my guess is that it would be a NE and DA reuptake inhibitor. Interesting how it shares the same positioning of the morpholine ring as phenmetrazine, plus it's metabolically stable without the alpha-methyl group...
 
Tertiary amine means theres probably not DA affinity, though. And the trifluoromethyl group makes me think of the 5HT2b agonists that were pulled from the market.

Probably not a great one, but this is approved for US prescription? If so, that'd exempt it from analogue status.
 
Phendimetrazine has plenty of DA affinity. Same with prolintane, fencamfamine, etc.

I think N-isopropyl-3-phenylmorpholine would be an interesting compound.
 
^^ Actually, phendimetrazine is completely inactive by itself. However, it is a prodrug: about 30% is metabolized to phenmetrazine in vivo, so it is still a wonderful compound (in fact, it is the only experience with phenmetrazine that I have, but it was still a good experience). Phendimetrazine is what benzphetamine is to regular amphetamine. Prolintane and fencamfamine are DAT inhibitors rather than substrates, so phendimetrazine should logically be a DAT inhibitor as well, but for some reason it doesn't even have a high enough affinity to be considering a meaningful DAT ligand.
 
Fencamfamine is a secondary amine

edit: in my experiences with a relatives collection of old weight loss drugs, prolintane sucked. Never had FCF, and didn't really enjoy Bontril.
 
Prolintane and fencamfamine are DAT inhibitors rather than substrates
Click to expand...

Fencamfamine is a weak monoamine releaser (as well as having some mu opiate receptor agonism)


edit: in my experiences with a relatives collection of old weight loss drugs, prolintane sucked. Never had FCF, and didn't really enjoy Bontril.
Click to expand...

That would be because prolintane used to be prescribed as a psychomotor stimulant with appetite increasing activity, not supression!
 
That would be because prolintane used to be prescribed as a psychomotor stimulant with appetite increasing activity, not supression!
Click to expand...

Never mind, I'm thinking of pipradol. I don't even know if prolintane is available in the US, actually.
 
Hmm... wonder if it's hallucinogenic with that 5ht2a agonism?

If one would add methoxy groups at 2 and 5 positions... To make a weird DOTFM analogue... hmm...
 
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