Sky News has obtained a video recording of a meeting on Tuesday where the health secretary made the remark.
news.sky.com
Warning over ‘realistic possibility’ of resistant strains of the virus emerging
www.independent.co.uk
just what i said was going to fucking happen these fucking retards in the government are brain dead are putting the world in more danger with this one shot then delaying peoples seconds shot by months. Now these new strains are already becoming vaccine resistant.
how exactly is the one shot protocol responsible for a variant which arose in South Africa where there is not a one shot or two shot program deployed or any large scale vaccination drive there? The South African variant, is clearly
not resistant because of the vaccines or the use of the vaccines, single shot 2 shot or fully auto. It mutated long before. The South African variant now may have a slight transmission advantage in vaccinated populations, if it gets into them but that would only be the case if the vaccine antibodies didn't also target some other part of spike which is unchanged in the SA variant, the vaccine antibodies are polyclonal and hit multiple epitopes on spike, in laymans terms they stick all over the damn thing and only part of the spike is changed in the variants.
So now could you care to explain to this retard how vaccines not widely used somehow selected for an escape mutant which has never contacted a vaccinated individual? did it involve time travel? or is the South African variant appearing nothing to do with vaccines.
The Oxford-Astrazenica vaccine has 3.8% efficacy pooled data 3·8% (95%CI −72·4 to 46·3) against infection (as opposed to around 60% efficacy against symptomatic infection), so practically all recipients of the Oxford AZ vaccine, one shot or two shot or one shot full dose half dose and a delay or no delay not important (yeah Oxford really fucked up their trial), will be infected on exposure at roughly the same rate as unvaccinated individuals and the selection pressure for vaccine escape mutants in those vaccinate people is high. But this is the important thing, this hasn't happened yet. It is likely not much better for Pfizer or Moderna only Moderna has been kind enough to supply some numbers and they are even more vague than the Oxford AZ numbers. These vaccines are not intended to eliminate or eradicate coronavirus or prevent infection, they can't and they won't but in vulnerable individuals they can make the covid into something with the same or lower risks as influenza.
If anything the mistake is not the one shot or 2 shot protocol, it is trusting trial data for efficacy and onset of protection to be replicated in the real world. The famous Pfizer BioNtech curve shows most of the divergence between active and control arms roughly 7 days after first dose, the control arm keeps getting more symptomatic infections and the active arm numbers don't increase much after 7 days post 1st dose. the difference between active and placebo is roughly 89% at day 21 just before the second dose and 95% 2 weeks after the second dose. That is the trial data which suggests that most of the work was done by the first dose (
in the trial) but the problem is that the trial was a carefully selected small group and the difference between the two groups is at most a few hundred symptomatic infections over a relatively short period of time. There are some other oddities in the Pfizer BioNtech trial which means don't take the headline figures at face value. It is likely all of these trials have likely overstated the real world protection they offer, because of the way the trials were designed and the speed at which they were operated. That is the take home message. Don't blame one shot or 2 shots for vaccines not doing something they simply cannot do.
But if the vaccines provide some individual protection against symptomatic COVID and where the relative risk of symptomatic Covid for that individual is higher than the risk of the vaccine then the vaccines are justified for that individual. Beyond that it is clear vaccinated individuals can become infected and transmit infection but perhaps half as well as unvaccinated individuals, but it only takes an average of 1.001 onward transmission events for eventual exponential runaway and there will come a point where a lot of transmission is in vaccinated individuals if vaccines are widely deployed. This natural infection of vaccinees which will likely be asymptomatic will simply boost the vaccinated individuals immunity to the level of a naturally infected recovered person so long as antibody dependent enhancement or some other quirk doesn't intervene. This not necessarily a good or a bad thing it just is. To take another example measles can and does infect vaccinated individuals they usually don't even notice, only their antibody levels show it to be true. Trouble is going to happen when governments think that vaccinated individuals cannot import infection and deploy vaccine passports.
