Well, I've been here four years now, and managed to contribute more than twice as much in virtually one subforum... here.
Keep it up, me having to respond to all your questions pretty irrelevant to this thread and the ONE question I keep asking of you
And what question did I ask you? I didn't ask you any questions, I'm not interested in anything you have to say. The one question you asked me was answered before you even asked it. The form of the information I provided in the quote from the PI sheet answered everything you asked for.
You couldn't find the PI sheet? That's either a bold faced lie, or I'm drowing in retardary. I found two editions of it, one generic for gabapentin from Neurontin, and a more recent version for Gralise, I'm pretty sure I could find it for Horizant too, but I'm gonna leave it at two. I've already put more effort into finding it than you have (what, did you not get off of Google's first results page? not even that far maybe??). All you had to do was search "prescribing information + neurontin (or gralise or horizant)." AND BLAMMOO! It's in the top three results for all of them! But again, I'll spoon-feed you the information, because for whatever reason, that's what you're looking for.
Even more ridiculously, is that I've already quoted from this earlier..
http://labeling.pfizer.com/ShowLabeling.aspx?id=630
Hydrocodone: Coadministration of Neurontin (125 to 500 mg; N=48) decreases hydrocodone
(10 mg; N=50) Cmax and AUC values in a dose-dependent manner relative to administration of
hydrocodone alone; Cmax and AUC values are 3% to 4% lower, respectively, after administration
of 125 mg Neurontin and 21% to 22% lower, respectively, after administration of 500 mg
Neurontin. The mechanism for this interaction is unknown. Hydrocodone increases gabapentin
AUC values by 14%. The magnitude of interaction at other doses is not known
http://www.gralise.com/lib/PDFS/GRALISE_PI.pdf
7.6 Hydrocodone
Coadministration of gabapentin immediate release (125 mg and 500 mg) and hydrocodone
(10 mg) reduced hydrocodone Cmax by 3% and 21%, respectively, and AUC by 4% and 22%,
respectively. The mechanism of this interaction is unknown. Gabapentin AUC values were
increased by 14%; the magnitude of the interaction at other doses is not known.
I'm confused. In one post you say
It was also originally claimed that gabapentin modulated GABA receptors
To which I said: " it's certainly not a claim they made in the research."
In another you say
And never said that gabapentin was claimed to be a direct gabaergic in Pfizer's PI sheet. But it's chemical similarity to GABA definitely was the reason it was first synthesized as a medication.
While you're right you didn't say that it was in the PI sheet, you were claiming that they misrepresented what it did, and what you did say was entirely irrelevant and as far as i can tell, untrue. The last bit is vague and relatively meaningless. It was synthesized as part of a large group of compounds exploring the effects of gaba analogues.
I tried biting my tongue. I failed, okay.
The discussion has gone on quite adequately
Really? Three posts had occurred, two were you, and another, from amanitadine (for whom i do have respect for), who summarized all of that up quite well as
worthless subjective descriptions
"almost like an opiate nod but w/o the euphoria", "actual sleep, rather than a nod" - so sleep, no euphoria, like a nod, but not like a nod?
I can see why you're not following between posts... sentences are tough.
I don't want to take away from the GABA-b agonist discussion & the OPer's question
Whhaaaatttt? Really? You haven't touched on the OP's question. You've just rambled about your experiences with baclofen. I didn't realize this subforum was about half answering questions with anecdotal evidence that vaguely relates to the question? Maybe this should be the "share short blurbs about the times you've taken baclofen thread" - I haven't heard anything about GABA-B agonists combined with opioids.
Unfortunately most of these comments just need a pubchem or med search and that's about all you can get without venturing into all of this subjective crap. At least you could confine it to actual combinations of gaba-b agonists and opioids. one or the other doesn't really provide any information.
if you would have been a member.
