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  • BDD Moderators: Keif’ Richards | negrogesic

Opiates/Including Heroin has been only cure for My major depression…

Hello again bdomihizayka,

"I'm not even going to waste my time with you after this post as you are just an attention seeker."

From whom am I seeking attention? I don't know any of you people and I will never meet any of you in person. How does one seek attention on an anonymous message board!? That doesn't make any sense. I posted my story online after reading other peoples' stories for months. I actually posted my story to help other people, because I know what major depression feels like and I know how frustrating it can be not being able to find relief. There are other people out there in the situation I was/am in.

"your borderline is very apparent which is why I was so easily able to identify you as such."

Lol. What a dick. You haven't identified anything and you aren't a doctor. I have ADD--its very similar to borderline. I was diagnosed with it and the lack of effect from cocaine and Adderall supports that diagnosis.

"You clearly don't want to help yourself. You just want a quick fix."

First of all, I didn't come here for help. This all happened to me back in March. I sought help outside of an anonymous message board, thank you. And in my case, I needed a quick fix, because I was/am suicidal. So yes, quick fixes are a good idea for such people. People diagnosed with major depression, 6% of them will commit suicide. I already tried to commit suicide this year when I jumped in the rapids. It was my intent to die that day.

"It HAS been proven that exercise is more effective than an antidepressant- high intensity exercise. Many studies are online, and you're here telling me it's all bogus?"

No, it has not been proven.

And I already posted on here that whenever I would go running, I would get MORE depressed. A few months in to the major depression, I signed up for this outdoor adventure club (this was related to the suicide attempt at the white water rafting get together). And I would go biking, kayaking, hiking…I signed up for yoga too and did that weekly. I would go to the gym at my apartment complex and run….MY DEPRESSION GOT PROGRESSIVELY WORSE! I felt alone, empty, my body hurt, I was exhausted, my stress got higher…It made me miserable…...What don't' you understand about that???? There are many people like this. I didn't write about the exercise because this post is a drug forum. I wrote about my experience with drugs. Not anything else. You just judged me quickly and assumed things right away and that is what pissed me off.

Many people say the same thing about exercise not helping them. And here is a study. Findings were exercise made no difference in depressive symptoms:

http://www.bmj.com/content/344/bmj.e2758

"An antidepressant IS a quick fix as opposed to a change in lifestyle."

How the fuck do you know what kind of lifestyle I lead? Yes, I used to drink alcohol, but besides that, You don't know what I eat. You don't know how physically active I am. You don't know what my spiritual beliefs are. You don't know what kind of hobbies I have. You don't know anything about me, aside from the story I posted about what happened to me this year and my experience with medications. As a matter of fact, I ran a 10K with my best friend right before the major depression set it. So STFU.

I didn't do drugs right away, if you even read my original post. I stopped drinking alcohol and went to a psychiatrist to get help immediately. I started a yoga regiment, went to cognitive therapy every week for months and tried different kinds of medications before I turned to "hard" drugs. That was the whole point to posting this story. NOTHING WAS WORKING. It is the title of the post!

So, you say you suffered from "extreme" depression? How long have you had depression? And can you describe to me what it felt like for you personally, to be suicidal?

Also, I'd like to know your personal experience using opiates?

"What I'm trying to say is that even the "anti-depressant" effects of an opiate are going to go away with time, and you are going to be dosing just to stay out of withdrawal WITHOUT any "anti-depressant" effects of the drug."

I'm pretty sure that even a tiny dose of an opiate can prevent withdrawal. I'm also pretty sure that junkies increase their dosages exponentially because they are chasing a high. I'm not. So, I don't think that is completely relevant to my situation. Like my recent response to Cliffy78, only time will tell if heroin ceases to alleviate my depressive symptoms. Just because I stop "feeling" it, doesn't mean it will stop taking the depression away.

"We have no idea how depression or any other mental illness works or where their origins come from. We don't know exactly how psychiatric medicine even works. The "serotonin" theory is just that, a theory. There is no definitive proof linking depression to any lack of certain neurotransmitters."

I've researched depression a lot in my spare time. Just because depression is a complex disease, doesn't mean that there is no understanding of it. Doctors do have an idea of how depression and other mental illnesses work and their origins. It is a scientific fact that depressed person's brain is different than a non-depressed person's brain (& exercise won't change that) Brain scans illustrate this and the differences are both significant and consistent. It is the consistency of difference that ensued in theories about neurotransmitters playing a major role. In addition, the medications developed to target neurotransmitters help a lot of people. SSRI's, MAOIs and other antidepressants are effective for over 50% of depressives.

This video is one of my favorite resources. It is a lecture by Sanford University's Professor Robert Sapolsky. I'll take his expertise over your's, thank you.

https://www.youtube.com/watch?v=NOAgplgTxfc


"You cannot name me a single doctor in a first world country who would give an opiate script for mental illness. Again, you're clearly delussional if you truly believe your own shit."

Dr. Robert T. Cochran

Below is his website:

http://www.understandingpain.com

Dr. Cochran has been practicing for decades in Tennessee. He wrote a book called the Opiate Cure. In it, he described his years of experience of prescribing opiates to patients with chronic pain. Patients who also had bi-polar disorder, or any mental disorder on the bi-polar spectrum, including major depression, were cured by the opiates intended for their chronic pain. His book is code for opiates curing mental illness. He cannot openly say it directly because he will lose his medical license, but everyone who knows about him and reads his books knows this obvious fact. I've read all his blog posts on his website too, and he is very good at inferring this. He also claims that many in his profession have seen the exact same results.

In one of his blog posts, he wrote his response to a desperate woman about her son who was suffering from major depression. Dr. Cochran wrote it was shameful that doctors won't prescribe opiates for him and inferred her to get it off the street if that was her only option. He blames the FDA for the illegal drug trade in this country because people are treating their mental illness with opiates because they're the only thing the works for them.

My doctor also prescribed me an opiate for major depression. He is a specialist in depression. He's been practicing for 40 years. The opiate he prescribed me is buprenorphine (Subutex). He prescribes it off-label all the time for patients who do not respond to his treatments.

I will not post his name on the internet for obvious reasons.

Doctors will prescribe opiates for mental illness. They are terrified of the FDA, but the ones that truly care about their patients will do it. Just because opiates aren't approved by the FDA, they can still be prescribed off label. The insurance companies just won't cover them.

"They have not been implemented for depression for hundreds of years."

Opiates have been used to treat major depression in the United States until the mid-1950s. Source: Bodkin J, Zornberg G, Lukas S, et al. Buprenorphine treatment of refractory depression. J Clin Psychopharmacology. February 1995. 15(1): 49-57.


"My best friend was "schizophrenic" and on many psyche meds. She had a food allergy- which once identified, cured her symptoms."

A food allergy made your friend schizo? You call me delusional?!

"Keep on popping your pills."

LMFAO. If I really wanted to, I could have an arsenal of "pills". I've been prescribed so many different medications, it was MY decision to stop taking them. I told my psychiatrist that I didn't want anymore Xanax, Klonopin, or Adderall. All of those meds are scheduled and can f*ck you up. I take opiates twice a day. That is the only thing I need and the only thing I take. And its the only thing that works for my depression. And Ill keep taking them until I get well.


"I was trying to help you- but apparently you don't want help, you just want attention. I'm not going to stroke your manipulative, dark ego."


I did not come here for help or sympathy! I came to this website and posted my story on the DRUG DISCUSSION board. I posted the aspects of my story that dealt with my personal experiences with DRUGS for my depression. I posted for 3 reasons:

1) I wanted to hear what others in the drug community thought about my experience with refractory depression and opiates being effective antidepressants.
2) I wanted to see if other people had similar problems (Cliffy78 and Falsifiedhypothesi)
3) I wanted to have my story out there so that people in a similar situation might find my story informative. Meaning, if they have refractory depression, they can ask their doctor about buprenorphine or try opiates themselves to help them through their difficult episode of depression

I didn't come here to get my "dark ego" or whatever the hell that means, here. You're so delusional.
 
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Hi ComfortablyNumb95,

"I'm sorry but this is no "cure". It's merely hiding the symptoms."

There is no cure for depression. And I have refractory depression, so it makes it even worse. I posted on this forum to relay my experience with various medications and how they were ineffective and how opiates have been helping me.

I wanted to hear everyone's thoughts about opiates as an antidepressant…instead I was attacked and told I didn't exercise enough, so I'm sure you can understand that I became very frustrated.

You know that exercise doesn't cure depression either, right?

Exercise does not cure depression.

Is this a body building forum? Are all blue lighters health fanatics or something? Unreal….

ComfortablyNumb,

How do you know my experience with exercise? I cam here to talk about drugs, not exercise. If I wanted to talk about exercise I would have gone to an exercise message board.
 
Hi ComfortablyNumb95,

"I'm sorry but this is no "cure". It's merely hiding the symptoms."

There is no cure for depression. And I have refractory depression, so it makes it even worse. I posted on this forum to relay my experience with various medications and how they were ineffective and how opiates have been helping me.

I wanted to hear everyone's thoughts about opiates as an antidepressant…instead I was attacked and told I didn't exercise enough, so I'm sure you can understand that I became very frustrated.

You know that exercise doesn't cure depression either, right?

Exercise does not cure depression.

Is this a body building forum? Are all blue lighters health fanatics or something? Unreal….

ComfortablyNumb,

How do you know my experience with exercise? I cam here to talk about drugs, not exercise. If I wanted to talk about exercise I would have gone to an exercise message board.

Aside from one poster I don't think anybody meant to attack you Cassandra. I empathize with you and I hope you get more out of heroin then what I did. I wish I could control my intake of it but as I said my addiction was unmanageable I was doing between 40-52 blue bags a day and my habit was about $300 daily(this was ten years ago sue prices changed). I ended up being a thief which was against my nature seeing how I didn't steal or any other criminal activities growing up(unless you count illicit drug use). I paid the price I went to prison and lost my world. I'm not saying this will happen to you and if you can manage it and it works then do you. Just please be mindful that it (addiction) can sneak up on you when you don't expect it.
Be safe my girl and I know it's hard but if this guy doesn't love you back break your addiction from him. I've been there too and it hurts worse then anything and sometimes(in my case) take years to overcome the hurt and rejection.
I want you to be well and get through this pain I promise your next love is out there waiting for you but you need to be clear headed enough to see him. Good luck and be safe!
 
Just an FYI to the "I'm pretty sure a tiny dose of an opiate would be enough to take away the withdrawal"

---it's not. If you have a 3-5 bag physical dependency you need close to that minimum dose to take away the wd symptoms.

And to your thought that junkies only go up in dose chasing a high--that's partially true, people tend to want to feel "better" than before. However, tolerance is not just due to that. If you dosed 3 bags a day for a few weeks, soon that 3 isn't going to have the same effect. You will need to increase just to feel the same as before

Have you tried only dosing about 2 mg of the buprenorphine? At that dose it acts like a full agonist such as heroin due to it not occupying all receptors, leaving some open for its metabolite which is norbuprenorphine. That works more like a traditional opiate. 8 mg more than saturates all receptors. Which is why with bupe those who know its mechanism will always tell you less is more

Having done opiates I understand what you mean about the way they make you feel. But on the flip side, should you ever become dependent (and it doesn't happen right away. You could shoot up for months straight and have no withdrawal and then one day your body chemistry has changed and you wake up feeling the worst sick ever...)...should you ever become dependent you will increase your depression many many times over. Stopping opiates puts people into a state called PAWS even after acute wd is finished which for a non-depressed under normal circumstance person can take months to come out of.

And as for acute wd---add vomiting, diarrhea, chills, absolute lethargy, RLS, anxiety, sneezing, eyes tearing, and insomnia for weeks. It will put you in the worst physical feeling of your life on top of the mental horror you experience now. And during PAWS your current depression would increase tenfold

I mention this because no matter how much $ you have or how good your source, there are always unforeseen circumstances which one day will leave you unable to get heroin. Unless you are one of the rare few who can use once a week...and never use back to back days...then it might never apply to you.

And never ever depend on someone else (your ex) to make you feel good/happy. That has to come from within. No person can do that for you--and what a burden to place on someone else's shoulders!

I feel for you, I can't imagine feeling like that all the time. I've had small episodes where I had no motivation to get out of bed or couldn't find joy in things I used to. But never long term. So if opiates make you feel alive and well, then have at it. They make a lot of people feel that way, that's why they are so popular! But just stay out of the daily use trap. Cause if you think depression is bad, depression plus opiate withdrawal is ten times worse.
 
Thank you for the kind words namnoc16!

I have a plan and goals that don't involve H, but H is helping me get there. It is a crutch until I get out of the mess I'm in. It helps me function normally to reach my goals. One thing I've learned through all of this is that I am emotionally weak. For years, I put on a facade of coldness and kept all my emotions inside. And this hit me out of nowhere, hard. And I couldn't handle it like a normal person.

It's just ridiculous though, that people cannot have a discussion on these message boards. I just wanted opinions on opiates for depression and to hear other experiences. If I had a penny for every time someone told me to "exercise" to cure my depression, I'd be a millionaire. I want to punch people in the face when I hear that because it's such a tripe and so annoying.

And people are so anti-opiate just because of the archetypal junkie images the media pushes on us; when in reality, there are a lot of functioning opiate abusers.
 
Just an FYI to the "I'm pretty sure a tiny dose of an opiate would be enough to take away the withdrawal"

---it's not. If you have a 3-5 bag physical dependency you need close to that minimum dose to take away the wd symptoms.

And to your thought that junkies only go up in dose chasing a high--that's partially true, people tend to want to feel "better" than before. However, tolerance is not just due to that. If you dosed 3 bags a day for a few weeks, soon that 3 isn't going to have the same effect. You will need to increase just to feel the same as before

Have you tried only dosing about 2 mg of the buprenorphine? At that dose it acts like a full agonist such as heroin due to it not occupying all receptors, leaving some open for its metabolite which is norbuprenorphine. That works more like a traditional opiate. 8 mg more than saturates all receptors. Which is why with bupe those who know its mechanism will always tell you less is more

Having done opiates I understand what you mean about the way they make you feel. But on the flip side, should you ever become dependent (and it doesn't happen right away. You could shoot up for months straight and have no withdrawal and then one day your body chemistry has changed and you wake up feeling the worst sick ever...)...should you ever become dependent you will increase your depression many many times over. Stopping opiates puts people into a state called PAWS even after acute wd is finished which for a non-depressed under normal circumstance person can take months to come out of.

And as for acute wd---add vomiting, diarrhea, chills, absolute lethargy, RLS, anxiety, sneezing, eyes tearing, and insomnia for weeks. It will put you in the worst physical feeling of your life on top of the mental horror you experience now. And during PAWS your current depression would increase tenfold

I mention this because no matter how much $ you have or how good your source, there are always unforeseen circumstances which one day will leave you unable to get heroin. Unless you are one of the rare few who can use once a week...and never use back to back days...then it might never apply to you.

And never ever depend on someone else (your ex) to make you feel good/happy. That has to come from within. No person can do that for you--and what a burden to place on someone else's shoulders!

I feel for you, I can't imagine feeling like that all the time. I've had small episodes where I had no motivation to get out of bed or couldn't find joy in things I used to. But never long term. So if opiates make you feel alive and well, then have at it. They make a lot of people feel that way, that's why they are so popular! But just stay out of the daily use trap. Cause if you think depression is bad, depression plus opiate withdrawal is ten times worse.


Hi Crzydiamond,

About the withdrawal, I just said that based on experience. My cousin was a hardcore heroin addict at one point--a full blown junkie. She was a very heavy user and I remember her "feeling better" from just one bag or a tiny little strip of buprenorphine. So, maybe it's different for everyone?

As for the buprenorphine, I would take 4mg twice a day. Or, 8mg at once (that would last me more than a day. It has a very long lingering effect). I have done smaller doses, but small doses don't make me feel any different. So that's why I had to increase my dosage. 8mg, I can literally feel the symptoms alleviate within 30 minutes.

It's good to hear from someone who actually had experience with opiates. I think I am managing my use well, though. I shoot up 2 bags in the morning and 1 in the early evening. This alleviates the depression, stabilizes my mood throughout the day and then helps me sleep. (Since I started doing H, I haven't had a need to take any sleep medication).

I've been regularly using for about a month now and I know I have it under control. I plan on stopping in January, because I'm moving across the country and starting a new career. I won't have a supply there anyway because I won't know anyone.
 
I know this might be frowned upon in a forum like this but its my personal experience. it helped me very much so i feel the need to share this experience.

Some time ago i also had problems with depression although not nearly as severely as yours. I experimented with all kinds of substances but they all just offered a temporary cure. This was not satisfying as i didnt want to have to rely on a substance for my mental health. Thus i came to psychedelics most of which were a fun time (LSD, shrooms, mescalin) and they helped me view life from a different perspective. They didnt help my depression tho.

But then one day i stumbled upon Ayahuasca and after trying it out 3 times i was stunned because it permanently made my depression better. It wasnt anything i saw or what i thought about during the trip. Just feeling the effects was enough to permanently make me a more positive person.

Of course ayahuasca isnt a miracle medicine and as with all psychedelics it could trigger a dorment psychosis but it helped me a lot so its at least worth mentioning.
 
I'm turning 21 in a few days so I just rounded to 5 years since I started at 16. I have always had depression, I remember when I was 8 or so I would tell my mom about how I wanted to kill myself. Right now my depression and anxiety are a lot less severe then they were a year ago but it's by no means gone away.

Opiates obviously aren't a cure but I think saying they just cover up symptoms is BS, if that's the case then that's exactly what antidepressants do as well, people will have a relapse into depression after stopping AD. What antidepressants and opiates do (though clearly not through similar mechanisms) is give a depressed person a period in their life where they can feel comfortable, motivated, and build good relationships. The difference is opiates carry much more risk than antidepressants and many people will end up getting lost in the highs and lows of opiates.
 
Hi Weltmeister,

Thanks, it is very interesting that you bring this up!

Before I even started opiates, I was researching ayahuasca and iboga. Because, people like us and falsiefiedhypothesi, having depression/anxiety our entire lives, obviously have deep seeded psychological issues that was caused by emotional trauma in our past. Theories say that this early trauma and ensuing stress made our minds develop differently, i.e neurotransmitters stopped firing correctly, low levels of certain chemicals or hormones etc. My doctor called it "brain damage".

I've read that psychedelic drugs put you into a trance where your mind actually fixes your mind. For iboga in particular, the deep introspection that you go into, causes your mind to repair itself in certain ways permanently. There haven't been any trials on this, but I believe there were official trials with LSD and shrooms about fixing such "brain damage". Iboga is also legal in the U.K (so it can't be THAT bad right? %) )

I was actually going to take a trip to South America to try iboga. After researching both drugs, iboga sounded better for my mental health issues. But since this has been all recent, I am still considering going down there and trying it!

My question for you: Where did you do the ayahuasca? And why did you do it 3 times? Didn't it work the first time?

Thanks
 
I'm turning 21 in a few days so I just rounded to 5 years since I started at 16. I have always had depression, I remember when I was 8 or so I would tell my mom about how I wanted to kill myself. Right now my depression and anxiety are a lot less severe then they were a year ago but it's by no means gone away.

Opiates obviously aren't a cure but I think saying they just cover up symptoms is BS, if that's the case then that's exactly what antidepressants do as well, people will have a relapse into depression after stopping AD. What antidepressants and opiates do (though clearly not through similar mechanisms) is give a depressed person a period in their life where they can feel comfortable, motivated, and build good relationships. The difference is opiates carry much more risk than antidepressants and many people will end up getting lost in the highs and lows of opiates.

O my yes you are young. And you started young!

I've had depression my whole life too. People don't understand that its like a cancer. It's always there. Sometimes you are fine…you can go months with being "normal"…then, it hits you and engulfs you like a dark cloud. Feels like your mind/body is eating itself. It's horrid.

I was actually okay last year, but I was still drinking a lot for the anxiety. Then the depression started creeping up…I felt it coming…then BOOM, traumatic event and it threw me into this unbearable state of being. I had a nervous breakdown…and the rest is history that I posted originally on this forum.

I agree with you that they don't' "cover up symptoms". They don't "numb" us either.

The way I describe what opiates do for depression, is they make you feel like there is hope. Opiates make me feel like I might NOT be better off dead. And that gives me motivation to get better through other means. Opiates also help manage emotion, they don't numb emotion.

I just wish people wouldn't judge us. We aren't dirty junkies robbing grocery stores for a bag or two. We are managing our depression in the most effective way we have found.

Wish you the best falsified; I don't' want to sound like a Negative Nancy, but you sound similar to me. It doesn't get better, unless you acknowledge and try and treat the depression. You are only 21 so you're on the right track. When I was 21 I was oblivious to my mental illness. And at 27 I had a nervous breakdown.

I think you will be okay if you keep using the opiates manageably and make sure other aspects of your life are on track--including getting an education and having a career that you truly enjoy.
 
I tried ayahuasca in the comfort of my own home. No special diet done and no abstinence from sex or whatever. All i did was not eat anything at the day i was going to take it. Luckily i happen to live in germany so i can just buy any plant material i need from the internet headshops from the netherlands.

There were a few problem why it didnt work my first few times. One of them was that my MHRB (Mimosa hostillis root bark) had really low potency so at my third time i had to use 30g which is way too much for good quality bark. Another problem was that i brewed it wrong and didnt listen to the advice on the nexus.

I think the main problem was that i didnt use enough syrian rue and thus the trip wasnt long enough. The first two times the trip was so short and faded so quickly that i hardly experienced any effects but my third time i took 1g of syrian rue 2 hours preior, 4g 1 hour preior and 1g after drinking the MHRB tea. I also strongly believe that Ayahuasca isnt just about the DMT. its also about the psychedelic effects of the Harmalas because in traditional ayahuasca brews they use high doses of caapi aswell.

The trip itself is really beautiful and to be honest i cant believe that anybody could have a bad time on it. It doesnt fuck with your mind like shrooms do and you can think very, very clearly with a euphoric bodyload unlike anything else.

If you want to learn about ayahuasca i recommend reading up on it on the nexus.

I cant say anything about iboga but from what i understand its only legal because its fairly unknown similar to salvia divinorum (which is extremely powerfull)
 
Thanks Weltmeister,

I will look into it more and probably will try it. I know there are places to go in Peru that mix the brew and administer it for you---under the supervision of a "shaman". I don't believe in all that mysticism, but I do believe in the psychological efficacy of "tripping" on natural substances.

I know I wouldn't feel comfortable brewing all that myself. And I don't know how I would obtain it, since I live in the 'States. I also watched a documentary about this place in Peru where Americans use Aya, and it seemed overwhelming. I would definitely want a shaman, doctor and other people to be there during my experience.

Also, most recently, I smoked marijuana. I never liked marijuana, but just did it because it was there. It was strong too. I had an out of body experience and tripped. I was on the outside looking in. My perspective of my behavior, feelings and actions this past year, completely changed. After that day, my depression has lifted exponentially.

I don't want to use substances (including opiates) the rest of my life either. With heroin, the reasons I know I need to quit are the illegality and expense. Otherwise, I'd continue to use it, because it has only brought joy to my life with no side effects and contrary to popular propaganda, it is one of the safest drugs in the world. I also don't want to continue to put money into cartel/gang economies. :X

I do believe, as you do, that psychedelics may be the key to curing certain mental illnesses (notably depression, anxiety and PTSD). Can't hurt to try.

Be well. :)

P.S "lucky [you] live in Germany": I lived in Germany for six months in 2012 at a language school in Munich. I made a group of German friends. When I went back to the States, I FedExed my one buddy OTC Unisom for his insomnia. He told me that you can't get any quality medications for such issues in Germany! :?
 
Perhaps you have a chronic undiagnosed illness? I agree about opiates helping with depression. I started to deal with being chronically ill with Myalgic Encephalomyelitis, feeling like low-grade flu all the time, from when I was thirty. I didn't start codeine until I was in my forties, for migraines. Didn't use codeine until my fifties and it made such a difference in being able to exercise, be social, just feel better.

I never felt I was "depressed," but the codeine was, as a friend said, "like being wrapped in a warm blanket." Safe. Secure. Happy. I slept better than in my entire life. I had a terrible breakup, my mother died, and realized I had PTSD from being emotionally abused for ten years. The codeine helped tremendously. It was like a barrier between me and the pain, as well as helping physical pain. It healed colds and flus faster too.

My problem was not taking breaks since I didn't think I was addicted. Now I do have painful withdrawal, so keep taking it. After having a shattered wrist and two surgeries, I was taking oxycodone, which helped me deal with feeling trapped, not knowing if I would be able to use my arm again, abusive treatment by doctors and a botched surgery. I cut back from 4 a day (plus 2 or 3 60mg codeine) to one oxycodone, but that's where I am now. I can't go lower without feeling awful. I'm trying hydrocodone instead of codeine since I can't get more oxycodone (my doctor can't prescribe it and I'm waiting to see a doctor who might be able to). I don't want to go through withdrawal. I feel badly enough. I'm 65, poor, but the opiates help me do as you said -- feel hopeful, happy, better. They wouldn't even be toxic if we could get them without toxic acetaminophen.

Anyway, I will not take other drugs, including anti-depressants. I think opiates if used carefully, could be a better substitute. I have three friends who go into emotional and physical agony of they stop their anti-depressants. A chronically ill friend was in agony from Cipro, given Lorazapam, and then Lyrica, and killed herself the next day. She refused to try opiates and only took them to kill herself. I believe if she tried them for her pain and depression, she would still be alive -- because part of the problem is that she could not lift out of the sadness in her life. Opiates have done that for me and my friends who also use them for chronic pain.

The only problem I see is that we do not have easy access, unlike those who can just go out and buy alcohol and tobacco, which are far more harmful.
 
I know I'm going to get patronized by more experienced opiate users…but please understand that everyone's situation is different.

I have had major depression her entire life (28 years) and March of 2015 was the onset of the fifth major depressive episode and is still going strong. This depressive episode was much different than all others and finally I sought professional help. Never before did I try any psychiatric medications or illegal drugs (aside from alcohol, which I self medicated with for a long time).

I was prescribed various antidepressants and anti-anxiety medications, including Celexa, Zoloft, Wellbutrin, Xanax and Klonopin and Adderall for ADHD. After these medications had no effect, I went to a specialist to get Ketamine injections for treatment of refractory depression, with no results.

After about 7 months of internal suffering, including suicidal thoughts and extreme self harm, insomnia, panic attacks, anxiety induced nausea and vomiting and depression induced anorexia/bulimia, in addition to me mutilating harm with razor blades, I was at rock bottom with the cancer that is major depression. No medications were working and I was desperate.

After a botched suicide attempt during a white water rafting venture in August 2015, I fell into a debilitating state of being. I couldn't get off the couch for 4 days and so, finally reached out to an acquaintance and asked for an opiate, which I've never tried before.

At first the acquaintance gave me Oxycontin 80mg, which I took orally. Within 40 minutes, my suicidal thoughts and urges to self harm were alleviated for the first time in 7 months. Optimism, an unknown feeling to me, also manifested itself within me.

Then, the acquaintance gave me H. Surprisingly, H wasn't relieving my symptoms. After I discovered that snorting large doses of H didn't get me high or help my depression, I went to see another specialist.

This psychiatric doctor believed me about the prior medications and the Oxycontin effect and prescribed me 8 mg buprenorphine for depression and said that my brain didn't produce dopamine and endorphins at a normal level, which has ensued in me having major depression and abnormal opiate tolerance.

Within 20 minutes of sublingually taking buprenorphine, my suicidal thoughts and urges to self harm were alleviated again.

I recently also injected H and again, my depression is alleviated. I can shoot 4 bags at once with only doing opiates since end of August. And I don't feel euphoric from this, my depression is only alleviated and I have a will to live.

I have 1 current and 2 former H addicts in my family and knows all about addiction and junkies.

But I think I would rather be addicted to opiates than live with major depression that will most definitely lead to suicide.

I would like to hear the thoughts of this community...


Thats fine.... how old are you?

The reality of the situation is that most people who take large amounts of opiates for a long time , eventually become extremely depressed and have "low mood" ..... so try to be honest with yourself...

you kind of sound like me..... I have adhd and depression.... and I was on adderall and klonopin combination for years... and it worked.... but i am a musician and a singer... and when i perform i like to take heroin.... so thats what i've been into lately... i just smoke some before i go onstage,.... and i try to take subs in my regular life (i usually end up taking heroin tho : ( )

Just be honest with yourself
 
Possibly it really works for some, but the addiction thing is just too real and too strong and it eventually will hit everybody.

There's interesting research about antagonising kappa receptors against depression (dynorphins, the endogenous ligands for them, potentially being dysphoric- but this isn't really established yet and maybe it isn't true for everybody), tianeptine which acts on opioid receptors too, as well that selective delta ligands might be good antidepressants but afaik we don't have such one yet.. and of course all the glutamate / NMDA stuff which is somewhat related to the opioid system, is all over very intriguing & helps with tolerance and addiction to them too..

From my personal experience (and study evidence supports this somewhat) I'd say opioids definitely have direct downstream effects on glutamate and especially NMDA neurotransmission, as well as - obviously - on dopamine. This mediates the antidepressant, stimulating effects some experience (maybe sigma receptors are involved too, but nobody really understands them yet) but also the rebound and withdrawal syndrome- NMDA antagonism can sometimes abolish opioid withdrawal and even make one 'skip' the whole w/d.. but of course the whole tolerance thing is much more complicated, it involves immune reactions and inflammation markers like interleukins and some more weird stuff... :)
 
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20+ years I've struggled with addiction. It got much worse after my son was murdered in 2002.

Did opiates help with my depression? Absolutely. Do they still help after all these years? No.

False sense of security is how I'd personally label it.
Sure, yer gonna feel great for a while, but you're "damaging" your dopamine receptors, which will result in depressiom settling back in over time.

Are you male/female? Have you had your hormones checked? Hormonal imbalances contribute to alot of depression, but this is overlooked by psychiatrist in most cases.

And some ADs (zoloft) don't interact well with opiates and some ADs have horrible side effect which can even induce suicidal thoughts.
 
Did opiates help with my depression? Absolutely. Do they still help after all these years? No.

False sense of security is how I'd personally label it.
Sure, yer gonna feel great for a while, but you're "damaging" your dopamine receptors, which will result in depressiom settling back in over time.
Yep, this is the point. It's probably a bit more complicated than just dopamine (the DA system is pretty good in recovering quickly at least up to some degree, think of e.g. cocaine --> high, crash, and after 2-3 days it's over), involving many other transmitters & systems ... but glutamate seems to play a key role.
 
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