Opiate anti-depressent properties

[jscript]

i knew you were going to say that

citalopram was great. i remember going to the gas station every morning before work and talking up a storm with the lady behind the counter. she must wonder what the hell happened to me. i found citalopram motivating as well, but it turned me into a dickhead (according to one mate (who knows if anyone else thought otherwise)). i was almost manic when i was on it. when i got drunk i got really arrogant. i could drink a LOT of alcohol too. i remember drinking a bottle of vodka one night and passing out in a mates car, unable to be woken. had 6 people rocking the car to wake me up. someone was gunna call the cops because they thought i was dead. the next night i got another bottle. i was pretty depressed... and invincible.

my only real problem with taking an SSRI again is that it will further mess with my lack of sex drive. from memory it might have improved my sex drive, but made it harder for me to achieve orgasm or an erection. i know SSRIs are notorious for messing with peoples sex drive. i am still only young, and i really value what drive i have left. im spewing i didnt make the most of it when i was younger. i was one horny motherfucker. lol.

when i was on citalopram i used to drink a lot of coffee. there was an amazing synergy. i dont drink coffee at the moment because it makes me feel anxious.

thinking back, i really enjoyed the stimulation i got from citalopram. i may try it again actually. probably a better choice than a drug used to treat opiate addiction.

 

[BilZ0r]

Yeah, I can identify with most of what you're saying. Initially the citalopram was pushing me more towards a manic state, and I did drink a lot of coffee, and I was horney as hell, with ED and anorgasmia to a degree.

However, most of that has passed. After about 3 months.

 

[IHateOpiophobes]

what about a pure mu-1 agonist? i am forgetting where i read this, but i believe it was somewhere one this board...that a pure mu-1 agonist would give all the positive effects of opiates (brightened mood, if you want to call it that, analgesia, etc) without tolerance/addiction. is this true, and is anyone working toward synthesizing a pure mu-1 agonist?

it seems like it would be a candidate for an antidepressant, if one really does not develop tolerance.

The Mu receptor = dependence.

 

[jasoncrest]

The Mu receptor = dependence.

I think he's talking about a mu recptor subtype.
Maybe some drugs that target a subtype of the mu receptor and no thers can be less addictive than non-selective mu agonists like Morphine.....

 

[redeemer]

I've found my SSRI gives me serious motivation. That's the main reason I started taking it.

I have a question that I feel is important. Is there a reason to believe SSRI's, or any other anti-depressant for that matter, cure depression instead of just alleviating symptoms while taking them?

 

[Smyth]

I think it's like diabetics and insulin. Suicide inhibitors have long lasting effects. I still think it's questionable to take mutagenic compounds that can covalently react with biological targets. It might be more realistic in terminal neurodegenerative disorders. I may be wrong in thinking this, but I suspect that the formaldoxime in Brasofensine reversibly hydrolyzes in vivo to the reactive aldehyde which is then free to react with cellular biological targets. Clinical indications from brasofensine are in treating Parkinsons.

 

[yellodolphin]

I found something Interesting that applies to this thread.

Sorry if this was posted before. I always figured Opiates were in some way connected to depression anxiety because of thier effects. Never knew why until in my Bio Psych course I found out about how opiates work in the body.

As im sure many people know one action of opiates is to block substance P. Substance P has been linked to depression and anxiety through various mechanisms. An antagonist of it was equal to an antidepressant for treating depression. Makes sense to me as opiates block sub. P also.

ref: https://profreg.medscape.com/px/get...3dy5tZWRzY2FwZS5jb20vdmlld2FydGljbGUvNDIwODQx

It seems to me depression and other psychological disorders are very complex in relation to Nervous sytem functioning and we are jus beginning to see the big picture.

 

[fastandbulbous]

I'm saying antidepressants don't add 1 to your mood.

For the most part, that's true, but you get the odd little one like amineptine (a tricyclic dopamine reuptake inhibitor) that produces mild euphoria in most people who use it. All the ones I'vew ever been prescribed for SAD were in no way euphoriant

You can class shit together all you want, its retarded.

Does that include the BNF or whatever's in use in your country? It's not retarded, it's a way of making individual drugs easy to access when information is required for treatment. Some people use drugs to treat medical conditions y'know...

 

[Dr.Heckyll]

The German pharm company Grünenthal has recently patented some derivatives of tramadol (destramadol = O-desmethyl-desoxytramadol) which have opioid as well as SSRI properties. They were more effective against anxiety than diazepam. They are supposed to be quick-acting antidepressants. Sounds like very useful medication. I just fear that the FDA says NO to anything than has an opioid effect.

 

[qwedsa]

if someone is depressed because of a problem with his natural opioid system, wouldnt that mean opiates could function as antidepressants for that person?

 

[yellodolphin]

if someone is depressed because of a problem with his natural opioid system, wouldnt that mean opiates could function as antidepressants for that person?

Interesting point u bring up. the endorphin system is linked to some cases of depression, as noted in my earlier post.

The only potential for opiate drugs in this situation would be to help deal with symptoms from this problem. If the natural opiate system is contributing to depression that could involve several things. maybe not enough production of endoprhin peptides, or it could have to do with the receptors themselves. In either case artificially stimulating the opiate receptors is not a permanent solution to this problem.

 

[fastandbulbous]

if someone is depressed because of a problem with his natural opioid system, wouldnt that mean opiates could function as antidepressants for that person?

Good luck on trying to get a doctor to see it that way - most will only act upon the results of clinical tests etc. Even if you could provide evidence to said doc, you then need to convince him/her that you have the condition and that it's the best course of treatment...

 

[Fried Man]

man, there are so many conflicting opinions in this thread.

Ok, again, I started this thread because opiates for me act like some super drug. They stimulate me, motivate me, euphoria, make me more social, no anxiety, confident, happy, and I can sleep whenever I want......and more.......

I know opiates don't have this effect on all people, but I know some people out there can relate. And of course opiates are not very useful antidepressents because of tolerence and addiction, but what I am interested in is some new chemical that feels like an opiate, in the unique way that it affects me at least.

Basically some opium without the tolerence and addiction and health risks.

Also, The same antidepressent effects that I get from opiates are probably similar to someone who is happy on prozac or zoloft. I just thought more people could relate to the wonderful feeling of opiates. Maybe it is just me that thinks opiates are almost the perfect antidepressent.

These new emsam patches are pretty damn effective though.

And the whole escaping reality though drug abuse. I would say taking drug like a maoi or ssri is kind of the same thing, to a lesser extent. Just taking drugs to esape the harsh reality that you're depressed when you're sober. Drug abuse is just usually alot worse for your health.

 

[MissMojoRisin]

Is there any research being done on the anti-depressent effects of opiates?

Like major pharmaceutical companies or just regular chemists trying to synth some opiate that gives you all the euphoria, motivation, and overall wellbeing, yet does not have the horrible addiction attached to it.

Lemme give you my background. I take amphetamines for ADHD. My mother thinks I get depressed sometimes, I think it's normal. My behavior is a bit unstable (ADHD hyper kid). My moodyness and unstableness is mostly due side-effects of the amps I think. Lack of sleep, bad eating habits. As well as occasional other polydrug use. My other problem is shyness. I can be social when I want to, but it's hard and often uncomfortable for me. I would like to be less shy. I also lack alot of motivation with things i'm not interested in. I don't have a strong work ethic. I hate doing alot of things like school and taking out the trash (yeh, somewhat normal, but I know alot of kids who feel rewarded for doing things like this.)

So to make me a bit more stable, happier about things, more motivated, and less shy, I have tried a few anti-depressents which really made me unhappy. Wellbutrin, Strattera, zoloft. The wonder drug for me is OPIATES!

Opiates for me do so many good things. I would def choose to be on it everyday if it was not so addictive.

-It makes me happy
-It clears any depression I have
-It motivates me better than amphetamines in most ways. Amphetamines always help me learn and study better, but opiates make work and annoying tasks way more fun, easier, enjoyable, and more rewarding than amphetamines. The combination of opiates and amphetamines are perfect for me. Happiness and the ability to focus and learn.
-It makes me social, and happy to socialize
-It stimulates my appetite and makes eating wonderful
-It makes sleep wonderful
-It makes me compassionate and caring with people I love
-It makes life better while I am high on it
-It kiss most pain

I just believe that some chemist could tweak an opiate chemical to make the perfect anti-depressent with very few side effects that would work for me. I know that some people do not gain these effects from opiates. But maybe some new opiate chemical could make most people feel the way I do.

so does anyone know if research is being done on this subject? I would dedicate my life to this, I just can't grasp chemistry.

I'm totally with you on this, Dude. Opiates relieve my diagnosed severe depression way more than fucking Zoloft and all the others (Paxil, Lexapro, Wellbutrin, Depakote) I've tried. Thing is, antidepressants are just as addictive as opiates. When I don't have my 50 mg of Zoloft, I can't function. I have brain zaps, crying spells, suicidal thoughts, lethargy, etc.. NOW, it isn't quite as bad as opiate DTs (major depression, lethargy, restless legs, climbing the walls, insomnia, aches and pains, liquid shits, etc..) BUT they are BOTH addictive. In my utopia, I'd use opiates for depression AND anxiety but alas, we live in a fucked up world where docs would rather dope you up with antidepressants so they can get their free hookers from Pharm Reps.

 

[getreal]

Is there any research being done on the anti-depressent effects of opiates?
So to make me a bit more stable, happier about things, more motivated, and less shy, I have tried a few anti-depressents which really made me unhappy. Wellbutrin, Strattera, zoloft. The wonder drug for me is OPIATES!

Opiates for me do so many good things. I would def choose to be on it everyday if it was not so addictive.

-It makes me happy
-It clears any depression I have
-It motivates me better than amphetamines in most ways. Amphetamines always help me learn and study better, but opiates make work and annoying tasks way more fun, easier, enjoyable, and more rewarding than amphetamines. The combination of opiates and amphetamines are perfect for me. Happiness and the ability to focus and learn.
-It makes me social, and happy to socialize
-It stimulates my appetite and makes eating wonderful
-It makes sleep wonderful
-It makes me compassionate and caring with people I love
-It makes life better while I am high on it
-It kiss most pain
I just believe that some chemist could tweak an opiate chemical to make the perfect anti-depressent with very few side effects that would work for me. I know that some people do not gain these effects from opiates. But maybe some new opiate chemical could make most people feel the way I do.
so does anyone know if research is being done on this subject? I would dedicate my life to this, I just can't grasp chemistry.

Oh, yea! I agree with you 100%!

My ope habit was way out of hand because of the major addiction properties- and the 'pain in the ass' time supporting my habit.8(

I think it it were developed as a 'perfect 'A/D' I'd do them again. In a heartbeat t
Even though today, as we speak, I will NEVER touch another ope.

 

[qwe]

In either case artificially stimulating the opiate receptors is not a permanent solution to this problem.

but artificially stimulating serotonin receptors is?

 

[yellodolphin]

but artificially stimulating serotonin receptors is?

um, I never said that.

I was careful not to mention SSRI's in my post as I dont think they are a good treatment.

I would rather be on an opiate then ssri any day actually. And i didnt say an opiate wouldnt be a viable way to help someone, I said its not a permanent solution. I choose my words carefully. Sigh, you cant control what people do to your comments after they leave your mouth, so many ppl misinterpret.

 

[bOrPaIdAlTeEyS]

ignorance is bliss

 

[johanneschimpo]

I would rather be on an opiate then ssri any day actually..

you're weird...

 

[yellodolphin]

you're weird...

y? have u ever done opiates? if so u might say the same

for one thing ssri's cause physical brain changes and they arent the best thing for ur body. natural opiates on the other hand are very safe and do not directly physically damage the body.