Olney's Lesions in Humans

[Gaz_hmmmm]

Is there any evidence at all for Olneys Lesions in Humans?

I've recently been using methoxetamine but am also prescribed methadone.

If NMDA antagonists caused Olney's Lesions then wouldn't people who've been on methadone a while end up with them or is the dosage of d-methadone not high enough for this to happen?

 

[JackiesBabyy]

I don't know why people worry about olney's lesions so much. They've never been observed in humans once in the history of NMDA antagonist abuse and have only been seen in rats after taking much larger equivalent amounts of what a human would take. DXM's neurotoxicity and cognitive decline is serotonin-mediated, and this is why people think dissociatives are so neurotoxic.

 

[Gaz_hmmmm]

Thank you. Using methadone I've never really thought about'em. I only started really thinking about them when I was using N2O and methaoxetamine

 

[sekio]

Olney's* lesions haven't been observed in monkeys or higher primates. As far as I know they are really only a concern if you are literally pumping huge amounts of NMDA blockers directly into brain tissue, a situation that never happens*.

* Not Onley's
** Unless someone starts putting PCP in their cancer CSF microdialysis pump

 

[phactor]

I don't know why people worry about olney's lesions so much. They've never been observed in humans once in the history of NMDA antagonist abuse and have only been seen in rats after taking much larger equivalent amounts of what a human would take. DXM's neurotoxicity and cognitive decline is serotonin-mediated, and this is why people think dissociatives are so neurotoxic.

Those of us who have been around awhile probably remember William White's papers. For quite some time they were accepted as fact by many.

 

[Hammilton]

Well, for one, anyone who knows anything about Olney's Lesions understands exactly why they haven't been seen in humans.

Anyone who doesn't won't understand this post.