Mental Health Nuplazid

[Gdvffh]

Hi all. I read there is an antipsychotic called nuplazid that is used to treat parkinsons psychosis but not for schizophrenia psychosis. Its interesting that they dont give it to schizophrenics with psychosis. Im wondering if this med would be good for psychosis and not cause the bad symptoms that we normally experience from antipsychotics. Like lack of motivation and cognitive decline. Has anyone tried nuplazid?

 

[plumbus-nine]

Hell yeah! Finally an antipsychotic which doesn't antagonize dopamine - this will indeed mean heavily reduced side effects. But it will also be of lower efficacy, they have been trying for years to develop an antipsychotic with favorable side effects, first Leponex, then the newer partial agonists like aripiprazole and now a TAAR1 antagonist is in the pipeline. I think Nuplazid is only indicated for Parkinsons psychosis because in this disorder dopamine antagonists can have even more horrible consequences than in the average person.

Pimavanserin acts as an inverse agonist and antagonist at serotonin 5-HT2A [5] receptors with high binding affinity (Ki 0.087 nM) and at serotonin 5-HT2C receptors with lower binding affinity (Ki 0.44 nM). Pimavanserin shows low binding to σ1 receptors (Ki 120 nM) and has no appreciable affinity (Ki >300 nM) to serotonin 5-HT2B, dopamine (including D2), muscarinic acetylcholine, histamine, or adrenergic receptors, or to calcium channels.[2][6]
Pimavanserin has a unique mechanism of action relative to other antipsychotics, behaving as a selective inverse agonist of the serotonin 5-HT2A receptor, with 40-fold selectivity for this site over the 5-HT2C receptor and no significant affinity or activity at the 5-HT2B receptor or dopamine receptors.[1]

Interested in reviews as well. Guess it will induce tiredness given its inverse agonsim at 5HT2a?

 

[Gdvffh]

Maybe. It fosnt antagonize dopamine receptors though so i would like to try it. Why dont they let schizophrenics try it? Kinda strange

 

[plumbus-nine]

Maybe. It fosnt antagonize dopamine receptors though so i would like to try it. Why dont they let schizophrenics try it? Kinda strange

This happens with many pharmaceutical treatment options. It is expensive to get something approved, and maybe they feared the overall efficacy in schizophrenics would be too low to get it approved. We have stuff like memantine for anxiety, opioid or stim dependence which is even proven to work (see PubMed publications) but it remains off-label thus rarely prescribed or covered by insurances. Or loads of promising stuff which fails early trials (in healthy volunteers of course) and gets shelved. I like that this one here doesn't antagonize dopamine. Though it might be that in Parkinson's as a disorder of low dopamine the usually artificial blockade happens already endogenously and adding this Pimavanserin just adds the 5ht2a component of modern atypicals. Maybe somebody with more expertise can shed some light onto this?

 

[Gdvffh]

Yeah i think im a go on reddit parkinson subreddit and ask them if they ever tried it and see if it causes cognitive decline and what not. Would be interesting

 

[Gdvffh]

Btw i also am waiting for that TARR1 agonist drug that is in development. My belief is it wont come out for like 3 to 4 years so we got a long wait for it to come. However i live in canada so the wait will be even longer for me. Hopefully the drug dosnt cause any cognitove decline or negative symptoms. I wish i could find more people on the drug and hear there experience with the drug then i would know if its actually worth waiting for or not.

 

[plumbus-nine]

Btw i also am waiting for that TARR1 agonist drug that is in development. My belief is it wont come out for like 3 to 4 years so we got a long wait for it to come. However i live in canada so the wait will be even longer for me. Hopefully the drug dosnt cause any cognitove decline or negative symptoms. I wish i could find more people on the drug and hear there experience with the drug then i would know if its actually worth waiting for or not.

Wonder about the side effects of TAAR1 antagonism, at last it's the target of amphetamine and phenylethylamine which might mean that there aren't the sides of direct dopamine antagonism but still negative symptoms.

Did you try sarcosine btw? It's said to work against negative symptoms.

 

[Gdvffh]

Yeah i just googled sarcosone and on reddit some people are saying that it helped and others are saying they didnt notice any difference. Ill order some sarcosine this week and try it out. Would be nice if it helps. I feel like if it really was helpful though i would of heard of it already as i try and read a lot on schizophrenia and this is the first im hearing of sarcosine.

 

[AlphaMethylPhenyl]

A lot of current research is pointing to small doses of abilify for negative symptoms. Think 5-15mg or so. Might want to ask about that one, not to derail or anything!

 

[n3ophy7e]

Yeah i just googled sarcosone and on reddit some people are saying that it helped and others are saying they didnt notice any difference. Ill order some sarcosine this week and try it out. Would be nice if it helps. I feel like if it really was helpful though i would of heard of it already as i try and read a lot on schizophrenia and this is the first im hearing of sarcosine.

If/when you do try it, please be sure to let us know if it helps! Maybe keep a journal of the effects each day, like a science experiment

 

[Gdvffh]

If/when you do try it, please be sure to let us know if it helps! Maybe keep a journal of the effects each day, like a science experiment

Yeah my sarcosine came in the mail today. Said would arrive next week thursday so it came quite a bit earlier. So far i took 1 pill. I think ill take 1 pill qt morning and one pill at night and let you all know how it goes.

 

[Dreeery]

Does anyone know anything about this drug?

 

[Dreeery]

They are conducting an experimental study and they give me the option to participate and test the drug