Nucynta and Methadone

[chrisOXY77]

Is it ok to take the 2 medications together? I have taken methadone a little while back and the next day went to take my nucynta and I felt shakey and weird as if it was not a good interaction. Is this because of methadones high binding affinity? and because of that the nucynta is trying to attach to the receptors but the methadone is over powering them? any help appriciated thanks everyone!

 

[nAON]

They are both opiates, so combining downers CAN be very dangerous. And as you said, methadone might be interacting in terms of binding, and it could be putting you into precipitated withdrawal.

The drug interactions checker says this:


Moderate Risk

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

 

[effie]

^ I am sure it isn't because nucynta is trying to attach to receptors occupies by methadone.

It ia more likely that nAON is right and given methadone's long half life, taking a second CNS depressant resulted in your symptoms.

 

[K'd-OUT-in-AZ]

They are both opiates, so combining downers CAN be very dangerous. And as you said, methadone might be interacting in terms of binding, and it could be putting you into precipitated withdrawal.

The drug interactions checker says this:

Moderate Risk

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

You can't get precipitated withdrawals from combining agonists with Methadone, your thinking of Suboxone