I'll say that even though I've gotten surprisingly good at finding my K drip spittoon while stuck locked in another dimension some still seems to make it to my gut, at least going by the nasty K burps I get afterwards

. Nothing like piss and burps reeking of K for a few days after a binge. I can't imagine taking it orally, blech. When I used to swallow my drip it reliably made bladder irritation much worse.
I've been trying grapefruit juice with mixed results, I can't really tell if it does much or if it feels more toxic or less toxic on the body.
One of my tricks that does seem to help potentiate visuals and mitigate the hangover a little is popping a B complex AND a flushing niacin suppliment, if the flushing doesn't bother you. Also a vegetable and nutrient-rich diet leading up to usage. Piracetam and ALCAR remove a lot of K's desirable effects, theanine is less severe but also doesn't do it any favors.
Yeah, piracetam is kind of the antidote of choice against dissociatives. I've thought of all the racetams working this way but apparently aniracetam even potentiates the visuals. I've made a thread about that in Ns&PD, Disso & Racetam Interactions which led to an interesting discussion btw
Ever only heard about grapefruit juice in combination with that wicked DXM, but need to read up about K metabolism ... strange that many people tend to dislike the drip of arylcyclohexylamines but do things like chew morphine XR pills, to me morphine is much more disgusting but guess it's individually dependent. A good thing about the more, but not excessively potent RC dissos like DCK is that the small amount will almost fully be absorbed by the nasal tissue. Indeed swallowed K is the worst for the bladder, don't really know why because the metabolism should be same, just with a heavy first pass effect. Maybe leads to a faster, heavier accumulation of norketamine, or - more worrying - you just don't feel the pain when the K hits the brain first as it is a strong painkiller on its own..
There came the interesting point up that this toxicity is putatively mediated by nicotinergic actetylcholine receptor alpha 7, for which some antagonists exist. DXM is one, memantine too for example but these are both dissos which will interact heavily. Had some pretty nice unique experiences with combining dissos but also some very very weird psychotomimetic ones (these tend to involve an opioid though). If you like DXM, you could try something like a low-medium "2nd plateau" or e.g. 250mg? and if the trip comes smooth, add some K

some people also do N2O on DXM so guess it's not really dangerous, at least not physically. This a nice thing about the dissos too, it's almost impossible to dangerously overdose with DXM being an exception cause of its intense SNRI activity.
Memantine indeed abolishes the irritation, at least the remaining bits of it, I never combined recently as the psychotomimetic features of the last times (specifically weird auditory phenomen which, with increasing dose of morphine, grew into something like whispers and multiple streams of thought.. almost completely disappeared upon quitting the morph but still scary as hell, for some time I've thought of having fried my brain and this as somebody who usually thinks that feelings of drain bamage being War on Drugs fueled hypochondria.. but I've seen psychotic/so-called shizo people in person, and it's nothing I'd wish to anybody besides these docs and corps making billions with shitty toxic and in many cases useless antipsychotics, and similar folks.)
May I ask at which point you've noticed the bladder irritation, was it just after a few trips or after heavy use of K? Does it go away with abstainance, and come back immediately or do you feel your body recovers with time?
The more potent ones are certainly less taxing, and even when it's obvious, stay well hydrated during and after dissotripping. They mask the sense of hunger and thirst sometimes completely and can dehydrate you.. I think I had the worst bladder irritation in reckless times when I didn't care about my health.. it partially heals over months but will always come back pretty quick, but thankfully it's just minor irritaton / frequent urge to pee but no real pain at the moment and stayed for this pretty some time now.
Thanks for your feedback on making a nasal spray. Now I have some questions about liquid ketamine I have acquired.
It appears that they are sealed in a sterile container - similar to what you would find from a pharmacy, but there appears to be dust and other floating follicles in the liquid. Is this any concern? Can I assume that this implies that the content is not sterile? If so, any suggestions for ensuring that the contents are sterile? I don't have any experience with im injection....
Umm, first need to say I have no experience with needles either as I am scared of them and see it somehow as a border I don't want to cross but certainly K is one of the exceptions which is tempting to try this route. You might consider plugging, some guys tell it's the most effective non-invasive route but the metabolism of K might well be different.. I've tried N-Ethyl-Ketamine once this way which was a baad mistake as that compound is much more irritating to the tissue, so I didn't continue trying - just morphine some times but only benefit for me was a higher potency but no faster rush or more euphoria than insufflated (my favourite route btw for all lesser irritating substances. K/2F/DCK give an almost instant rush, guess i.m. will even be slower but maybe 1/3 to 1/2 (?) more potent.
Dust inside a sterile vial doesn't sound too good to me somehow :/ You could possibly add a bit of destilled(?) water and cook it for some minutes, then filter. Some people dry K in the microwave to get crystals for snorting, never did that out of lack of access to pharm grade K but it certainly works by putting a plate on top of a water-filled pot and pour the solution on the plate, boil the water and wait until the solution evaporated and you'll be left with crystals. Works at least with morphine. Of course room temperature does the same but much more slow.