Misc Nortriptyline

[madog11]

Anyone know how these actually work? What do they do in the brain that affects chronic migraines? I have only found that it's not really known but there must be some studies, some idea out there somewhere that can at least explain a little how it gets rid of them and what must be wrong in the brain for them to work?

I ask this because they do get rid of my daily headaches and i'd really like to know how.

 

[Albion]

Hmm. Interesting stuff...Nortriptyline, it's usually prescribed for depression and bed-wetting in children. How bad are your migraines usually? And how well does this help? I know someone who suffers from really crippling migraines, and his DHC prescription does barely anything for him (although it does get him high).

 

[madog11]

Hmm. Interesting stuff...Nortriptyline, it's usually prescribed for depression and bed-wetting in children. How bad are your migraines usually? And how well does this help? I know someone who suffers from really crippling migraines, and his DHC prescription does barely anything for him (although it does get him high).

Was getting everyday migraines for the last 3 years or so. This has cut them down to max 1 a week. On 75mg Nortriptyline and 160 propraolol cause i have the opposite reaction the nor than most, it makes my heart race. It's the best drug i've ever been on for my headaches in 5 years. Read the wikipedia page and most other things that come up on google ended up on some stuff about Norepinephrine reuptake inhibitor that i don't understand could do with a layman explaination about what it does in my head.

Oh and opiates are a bad idea as you get rebound headaches.

 

[Venrak]

I'm pretty sure they're 5ht2 receptor antagonists, more precisely it antagonizes the receptors along major blood vessels causing something that stops the migraine. I'd assume due to vasodilation or somesuch mechanism.

 

[Jabberwocky]

Haha i was prescribed this for depression in 5th grade... awesome you've found something that works well for you md

 

[Venrak]

lol

 

[Alex000]

It works through mainly serotonergic, noradrenergic, and anti-cholinergic mechanisms. It has some anti-histaminergic properties, which are beneficial for migraine prophylaxis, too. All in all, I have heard good reports about migraine prophylaxis with TCA's.

 

[madog11]

It works through mainly serotonergic, noradrenergic, and anti-cholinergic mechanisms. It has some anti-histaminergic properties, which are beneficial for migraine prophylaxis, too. All in all, I have heard good reports about migraine prophylaxis with TCA's.

Can you explain that in laymans terms?

 

[Alex000]

Can you explain that in laymans terms?

Well, I am not sure exactly how, I just refered to the neurochemicals notriptyline effects. Frankly, I do not know exactly how this relates to how it works (the acutal mechanism), but it does. I think, I think that a lot of what it does prevents from the excessive vasodilation occuring during a migraine due to some serotonergic (serotonin-related) response which causes the pain.

 

[madog11]

Well, I am not sure exactly how, I just refered to the neurochemicals notriptyline effects. Frankly, I do not know exactly how this relates to how it works (the acutal mechanism), but it does. I think, I think that a lot of what it does prevents from the excessive vasodilation occuring during a migraine due to some serotonergic (serotonin-related) response which causes the pain.

Thanks, thats a better explaination than i've found so far online.