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Opioids Nodding Out on Methadone

Eva 33

Bluelighter
Joined
Mar 19, 2009
Messages
75
I’ve taken virtually every prescription opioid for chronic pain. I’m not very sensitive to opioids and I can tolerate pretty high doses. Morphine, Dilaudid, OxyContin, etc.

However, I seem to have a problem tolerating Methadone, and I’m wondering how common this problem is?

Never before have I nodded off on ANY OTHER opioid. But it seems like each time I’ve tried Methadone (10-30 mg. daily), by day 2 or 3 I end up basically losing consciousness, which is scary! I guess it’s technically putting me to sleep? All I know is that I’m losing time, and falling asleep in very strange places and strange positions. I’ve actually fallen asleep sitting up in a kneeling position on the floor. I have no idea how long I was out for, but my muscles were in such a strange position that I ended up having sore legs for a week afterward.

The weirdest thing is that every time I wake up from losing consciousness on Methadone, my face is red, as if I’ve been sunburned. A couple days later, I get some peeling on my face, as if from a bad sunburn. But every time I’ve nodded out, I am INSIDE MY HOUSE. That’s beyond weird.

The first several times I nodded off/fell asleep on Methadone, I didn’t totally connect it to the Methadone, even though I NEVER just fall asleep during the day. (I did more often fall asleep from it at nighttime, so I thought maybe I was just tired.)

I finally realized it was definitely from the Methadone when I nodded off on a bench in public (so embarrassing!) I’d just finished eating at a restaurant I sometimes go to, and sat on a bench just outside the restaurant. Well, before I knew it, the cops had pulled up! They started questioning me. Someone from the restaurant said that they’d seen my eyes rolling up into my head. They thought I was having some sort of a medical emergency, so they called the cops. (I suppose it’s good that I never even order alcohol at the restaurant, because neither the waiter nor the cops accused me of taking anything.)

Fortunately, I’m able to snap to it and appear “normal” when I need to. The cops were asking me stupid questions like, “Who is the President?” The waiter must have told them I was in a bad way, but fortunately I was able to act normal and alert in front of the cops. I answered all of their questions, and they finally left me alone. Of course, they suggested I go home. They asked me if I was driving? I told them I was walking, but I actually was driving (less than a mile, and I’ve never had any problems with impaired driving.)

Still, this whole episode has shaken me up. I live alone, so nobody else had ever witnessed my “nodding out” before. The way the waitress described it, it must have looked scary, like I was completely losing consciousness. Maybe they thought I was dying. No, I definitely don’t want to die from this stuff!

Is anyone else totally able to handle high doses of all of the other opiates, yet has this reaction to Methadone? 30 mg. is a fairly low dose, right? Since it seems to happen the second or third day I’m on Methadone, I’m guessing the Methadone must be having a cumulative effect. I’ve never taken Methadone for more than 3 straight days.

My chronic pain is episodic now, so I’m not on constant opiates. Although I used to be, for years. Fortunately, my pain is no longer constant.

Right now, I’m on 48 mg. Exalgo (long-acting Dilaudid), after not taking anything for nearly 4 weeks. So even though my tolerance must be low, I’m having zero sedation from the dilaudid. Nobody would ever guess that I’m on opioids. I’ve always been someone who could really “handle” opioids without any visible side effects. (Not always such a great quality, because it means I need fairly high doses to control my pain episodes.)

Anyway, just wondered if anyone else experiences “nodding out” on Methadone, but not with any other prescription opioids? Does anyone know what is different chemically about Methadone that causes this? I think I have read of this happening to people on Methadone, although I’m not sure that this didn’t happen to those people with other opioids, as well.

Thanks for any feedback about your experiences.
 
Not experienced with opiates, but I know methadone is not a clean opiate, it also has NMDA antagonist activity. That is usually how dissociative anaesthetics such as Ketamine and PCP work... might be worth checking.
Did you ever take any dissos?
 
I was a junkie/pillhead and used methadone then subs to detox.
Methadone gave me a better knod then pills but no euphoria.
Maybe lower your dose because it is a very strong medication
 
Yeah methadone ks notorious for making you tired. It took me a long time to adjust to my daily dose of 80mg. Id be going cross eyed at work and drifting in and out of sleep.
This happens to a lot of people.
For everyone I've talked to about it, and I agree, it's not a pleasant, euphoric nod, it's just really intense tiredness.
Are you getting the methadone off illicit sources? Why do you take it?
Maybe lower your dose.
And yes, due ti its long half life, it does have a cumulative effect.
 
You answered your own question, yes, methadone has a super long halflife that's y by the third day you experience this type of effects. I've never actually tried methadone(I have only done codeine, oxy, morphine and fentanyl) but I've read that it is a pretty strong opiate. I think if ur having these kind of negative fx you should lay off the done. stay safe NZN. ?
 
I can't get my day started until I get my Methadone Dose in Me and it only makes Me tired if I haven't been asleep or got good sleep which speaking of which I need to get to bed. Oh and Methadone will build up to full "Blood Plasma Levels" in your body which will be twice the Amount of whatever your Absorbing Daily after 21 Days A.K.A. 3 Weeks of Daily Continuous use.

The problem is you can absorb anywhere from 40% to 99% but Methadone Absorption and equivalent Dose build is the most impossible thing to determine even if you knew the exact Amount of Drug you absorb Daily like for Example if the Methadone was Injected Daily in a Hospital Setting the problem is everyone has different Amounts of natural CYP3A4 and 2B6 and 2D6 which correct Me if I am wrong but the Over-The-Counter Orphenadrine I use it One Hour before my Methadone mainly due to it being the only nearly 100% Inhibition of CYP2B6. Methadone and I have seen Studies claiming Orphenadrine had Chronic Pain Patients on Hydromorphone get stronger pain relief. Orphenadrine is not a Selective CYP2B6 Inhibitor it is like Strong a CYP2D6 and Moderate CYP3A4 to Strong Inhibitor. Orphenadrine which is slightly changed in Structure Version of the Diphenhydramine and it has Anti-Cholinergic Activity NMDAr Activity albeit it's nowhere near as strong as just a simple and plain Dose of Dextromethorphan but people like myself try to stay away from it between trips which I been taking a 2 Year Break or a true 100% NO NMDAr Drug Use for 1 Year as of April 20th and I plan to wait another Year which would be 2 Years before using any Ketamine or something similar.
 
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