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  • BDD Moderators: Keif’ Richards | negrogesic

Opioids No more effect or euphoria from oxycodone?

pnillyg

Bluelighter
Joined
May 3, 2024
Messages
681
I have been using oxycodone for years and in the last few weeks I have been no longer achieving really any effects at all from it. Just trying to not be sick and that’s barely working. I’m dosing about 60-90mgs every 4-6hrs. Does anybody have advice to help them work again or better? I’m worried that in search of making them adequate for my issues again I’m entering overdose territory but I don’t know. I’ve tried plugging, insuflating, and sublingual administration, but haven’t really had any success. I’m also nauseous almost all the time and have been noticing a ringing in my ears as well. Does anybody have any advice on how to make it work again or at least help? I just need to make it the 23rd of the month to Detox and I’ll be free once and for all. Peace and love everyone.
 
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I am not a bringer of a happy anecdotal experience. About 7 years ago after codein, few experiences with buprenorphine, then a longer stint with morphine (my first kick), methadone here and there I got an chance to have pretty hefty dose of oxy for free or near free. I used opioids for then untreated severe chronic pain (which is under control now finally). Used oxycodone for around 9 months. I needed ~100mg of 55k just to be out of "sick territory" For catching a great buzz I had to take 50% more. After that I was on ORT for- firstly bupe, then methadone then back to buprenorphine and after 3 years of ORT I kicked buprenorphine. I tried to work without opioid pain killers but pain came back with vengeance. Before I went on ORT I tried to use oxycodone again. But this time it was different and I never got that antidepressant/energetic/euphoric effects from oxy. I was frustrated and I even tried megadosing with 3-400mg. Sleep was perfect buu besides of some nodding - oxycodone was not an opioid that previously had me on the cloud 999. It was like I was taking entirely different opioid then before. I don't know what changed but ocycodone stopped working for me. To be honest it was a better that way for me cause I loved the feeling oxy gave me waay too much.

For the record - all oxy that I took was old OC formulation and they were all from the pharmacy.
 
You can try TO REDUCE tolerance with naltrexone , with ultra small doses of it. Theres a very interesting thread about it. It seems that naltrexone can reverse tolerance of opioids. I have never tried but theres some people here who do it.

Another way is to taper down the most you can to a low dose. Then come up again with a large dose again.
 
You can try TO REDUCE tolerance with naltrexone , with ultra small doses of it. Theres a very interesting thread about it. It seems that naltrexone can reverse tolerance of opioids. I have never tried but theres some people here who do it.

Another way is to taper down the most you can to a low dose. Then come up again with a large dose again.

I agree with this. You need to take smaller doses. You will be sick the entire time. But your tolerance will lower. Picture taking 10mg a day for a week. It’ll be like you kicked down to a 10mg a day habit. So if your on 60-90 then say 30 and you can like wise get double the strength of your oxy back. But the truth is you’ll be sick the entire time, extremely tempted to use, and it’ll be right there. It takes some insane willpower. I’ve experienced this method working after bags of really good dope. I’d get a bag of lesser quality and be sick for like a week while doing loads of bth. Then after a week it was suddenly like it started working again.

It works, but it isn’t fun.
 
ok good to know. I’m struggling cause the detox even told me to “keep myself comfortable until I get there” but it’s just not seeming like an option. Also don’t want to detox before my detox but looks like I want the cake and to eat it too. Idk keep the advice flowing and all is appreciated. Will keep everybody updated. So far today took 45mg and going to see how long I can go without another dose.
 
Thankfully, buprenorphine does not seem to do the same. I’ve been on it for 12 years now and have not relapsed

I think it might have to do with its effect on kappa opioid receptors. As well as the naloxone in the suboxone formulation which could theoretically reduce tolerance in a similar manner to low dose naltrexone.

-GC
 
Whatever you do, do not continue to increase the dosage. If Opioids lose their efficacy, the best way of restoring it is by reducing intake, taking days off, reducing tolerance. Increasing the dosage to restore effects is the universal trap that almost all users will eventually find themselves in. This leads to a cycle of diminishing returns that ends with complete tolerance to the beneficial effects and the user needing Opioids simply to maintain a "normal" state.

It isn't what anyone wants to hear or wants to do, but the best way to regain beneficial effects is by reducing the dosage.
 
Whatever you do, do not continue to increase the dosage. If Opioids lose their efficacy, the best way of restoring it is by reducing intake, taking days off, reducing tolerance. Increasing the dosage to restore effects is the universal trap that almost all users will eventually find themselves in. This leads to a cycle of diminishing returns that ends with complete tolerance to the beneficial effects and the user needing Opioids simply to maintain a "normal" state.

It isn't what anyone wants to hear or wants to do, but the best way to regain beneficial effects is by reducing the dosage.
I’m already there boss.. but appreciate the warning. Hopefully can come out of this one for the last time
 
I’m already there boss.. but appreciate the warning. Hopefully can come out of this one for the last time

I hear you buddy. You're already in a bad spot, but you can still stop increasing the dosage. You don't have to stop or quit. It's still a huge step that you would deserve a lot of credit for, but the first step you can take is by putting the brakes on the increases. I know you can do it. Once you get that first step done, you can evaluate from there.
 
I hear you buddy. You're already in a bad spot, but you can still stop increasing the dosage. You don't have to stop or quit. It's still a huge step that you would deserve a lot of credit for, but the first step you can take is by putting the brakes on the increases. I know you can do it. Once you get that first step done, you can evaluate from there.
I appreciate that I’m going to find a baseline and slowly decrease until my detox comes. Been trying to do this but been having trouble with it if you have any suggestions let me know as far as dosing schedule or honestly anything helpful. I have other medications but they told me to just overcompensate with opiates rather then introduce benzos or sleeping meds. I guess Iboga doesn’t work with those.
 
I appreciate that I’m going to find a baseline and slowly decrease until my detox comes. Been trying to do this but been having trouble with it if you have any suggestions let me know as far as dosing schedule or honestly anything helpful. I have other medications but they told me to just overcompensate with opiates rather then introduce benzos or sleeping meds. I guess Iboga doesn’t work with those.

Unfortunately, we have very, very little information regarding the effects or efficacy of the so-called "Ibogaine Treatment/Therapy". For anyone unaware, Ibogaine is an herbal/plant-based treatment that is alleged to arrest/stop the compulsive/addictive behaviors associated with Opioid addiction. It's a psychedelic/hallucinogenic experience that lasts for a few days. At the end of the therapy, the goal is for the patient to essentially have their addictive behaviors and habits erased or otherwise highly reduced. I've read conflicting reports regarding what happens with the physical dependency aspect of things, with some saying there is still withdrawal and others saying that too is erased. The treatment is known to be limited to Opioid-agonist substances.

Part of me really would love to believe that this is effective. It would be great to have a magic eraser for a problem that requires, for most, a near-lifetime of dedication and focus to overcome. I begin to get worried when I read reports of the need for additional treatments for some. I've also read that users dependent upon the much more powerful substances like Fentanyl(s) and Nitazenes have less success than those dependent upon stuff like Morphine/Heroin.

Part of me believes that no matter what happens, a person must invest time and energy into fixing their psychological problems, otherwise even a magical cure like Ibogaine still would mean little. We are addicts. It wouldn't be out of character for one of us to receive a magical cure of our dependence/addiction only to take that as an awesome reset of their tolerance with which they can do it all over again. Anyway, I'm getting off topic.

@pnillyg you're unlikely to be able to make positive changes in your intake while you're still in direct control of the drugs. Like many situations discussed here at BL, we have to separate the "possible" from the "probable". It's "possible" for an addict to have a huge stash of drugs and decide of their own free will to begin using that stash responsibly with a mind to future abstinence. It's "probable" that they will continue to use the stash, not reducing but in fact getting worse.

I'm not judging. Everything I'm saying would be 100% true for myself also. I never decided I needed a change until something truly terrible had happened and I had experienced a great deal of pain and misery.

The only rational suggestion would be to entrust these drugs to someone that you trust. I truly feel that is the only chance you have for using them in any way that might help you in your quest for reduction and/or sobriety. We can help you make a plan. Once you have the plan, you commit to it, give the drugs to this person and have them dole them out to you only according to the plan. You let them know that although it may seem crazy, it's part of a larger plan to get you to a treatment.

For a lot of people, the only solution is the hospital/detox. It is the only way that they're able to put a true barrier between themselves and the drugs. Detox is often not perfect or exactly what we want. It sucks, but sometimes we have to admit that there is no way out of the problem in which we are pulling the strings because we have completely lost control of our minds.

The most ideal situation would be a family member or close friend holding the drugs. If this isn't possible, I'd wager you could convince someone from NA or a similar group to do this for you, again, stating that it's for a very short time while you prepare for treatment. Let me know if any of this sounds like it could work or if you have any further questions. We can figure this out.
 
Thank you for the information and apologies if I was too blunt or posted incorrectly I never mean to disrespect or cause confusion I’m here purely to gather information and to share experience. Thanks for the understanding and will be more careful moving forward.
 
Whatever you do, do not continue to increase the dosage. If Opioids lose their efficacy, the best way of restoring it is by reducing intake, taking days off, reducing tolerance. Increasing the dosage to restore effects is the universal trap that almost all users will eventually find themselves in. This leads to a cycle of diminishing returns that ends with complete tolerance to the beneficial effects and the user needing Opioids simply to maintain a "normal" state.

It isn't what anyone wants to hear or wants to do, but the best way to regain beneficial effects is by reducing the dosage.
I am in almost the exact situation with prescribed oxycodone, I am only on 40 MG.
How long and how much should be reduced to get back effects( pain relief, and yes a bit of a mood lift)?
 
Also, I have been on a low dose a while.
I quit morphine when the pain decreased. I have no love for opiods other than medicinal.
I forget to take them and am reminded by my pain issues. I have no psychological addiction and I never have withdrawals.
I kept my tolerance low for about 7 years. Now it has increased and my doctor said if it weren't for the state he would give me more.
I just want pain relief and to be able to eat. I only ever got a 10mg bump, when on my own I decided that the chronic pancreatitus was gone and stopped 60mg of morphine that I also took.
If I had no pain I would taper off completely.

Alcohol is like crack to me. I only quit when I got a DUI because my liver stopped processing booze, then 18 hours later a bunch of stored up booze hit me.

Now I am allergic, that stopped me. I HATE ALCOHOL NOW.
But I just want my low tolerance back.
I really am not into opiods recreationally.
I can control use and never run out. I always have extras if something goes real bad, but no psychological addiction.

I can control it, seriously. Do you have any suggestions on how much decrease and for how long?
 
Also, I have been on a low dose a while.
I quit morphine when the pain decreased. I have no love for opiods other than medicinal.
I forget to take them and am reminded by my pain issues. I have no psychological addiction and I never have withdrawals.
I kept my tolerance low for about 7 years. Now it has increased and my doctor said if it weren't for the state he would give me more.
I just want pain relief and to be able to eat. I only ever got a 10mg bump, when on my own I decided that the chronic pancreatitus was gone and stopped 60mg of morphine that I also took.
If I had no pain I would taper off completely.

Alcohol is like crack to me. I only quit when I got a DUI because my liver stopped processing booze, then 18 hours later a bunch of stored up booze hit me.

Now I am allergic, that stopped me. I HATE ALCOHOL NOW.
But I just want my low tolerance back.
I really am not into opiods recreationally.
I can control use and never run out. I always have extras if something goes real bad, but no psychological addiction.

I can control it, seriously. Do you have any suggestions on how much decrease and for how long?
Somebody recommended low dose naltrexone (ULDN) to reduce tolorence but I have 0 experience with it and quite frankly am skeptical about it cause it can cause precipitated withdrawals. May be worth looking into though and I’m curious what @Keif' Richards has to say regarding this topic.
 
Sadly guys, I just don't know enough about this Ultra-Low Dose Naltrexone (ULDN) therapy to confidently comment on it. I will say that I've read some things, heard some things etc. that indicate it has some promise. I believe that it can be effective for reducing tolerance/renewing analgesic effects from Opioids, as I've both read and heard anecdotally from folks that it has worked.

It's relatively new on the scene. I would want to know what the side effects could be. Is there a possibility of precipitated withdrawal? Is the treatment essentially "infinite", like if done properly someone could cycle on and off this stuff for life? There are just a lot of questions for me, though the research and experiences seem to indicate that it has legitimate value for this purpose.
 
I have been using oxycodone for years and in the last few weeks I have been no longer achieving really any effects at all from it. Just trying to not be sick and that’s barely working. I’m dosing about 60-90mgs every 4-6hrs. Does anybody have advice to help them work again or better? I’m worried that in search of making them adequate for my issues again I’m entering overdose territory but I don’t know. I’ve tried plugging, insuflating, and sublingual administration, but haven’t really had any success. I’m also nauseous almost all the time and have been noticing a ringing in my ears as well. Does anybody have any advice on how to make it work again or at least help? I just need to make it the 23rd of the month to Detox and I’ll be free once and for all. Peace and love everyone.
You're not going to like this but you have to get off opioids for a few years at least before you'll start getting the buzz. When you take opioids it physically alters your brain. The opioid plugs up the nuerorecptor forcing your brain to make more. It can take years for your brain to undo the changes. I've been on opioids for half my life and it doesn't matter how much I take, I'm not going to get that buzz :( As for being sick you can ask your doctor for ondansetron, dimenhydrinate or one of the other nausea meds. The di one is OTC.
 
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