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No Interaction with New AD Viibryd and MDMA/LSD

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Swim15

Bluelighter
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Sep 11, 2016
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I posted yesterday on how I believe I successfully reset my serotonin system essentially back to baseline or better.

I wanted to add to that that my girlfriend also rolled with me two nights ago after being on Viibryd (20mg) for about the last two months.

It’s been a miracle life changer for her and personally my favorite AD on the market given it’s mechanism of action and much better/safer profile than most clinically used ADs.

She skipped the two days before the show (no noticeable mood changes noted) and dropped 200mcg LSD followed by approx 130mg of MDMA after the peak. Neither compound was blunted at all and she rolled just as usual with all the love, ampathy and typical effects and no noticeable difference.
 
What do you mean reset your seratonin system back to baseline or better?

What does that mean, exactly?
 
Check the other read? Maybe link me? I'm not doing research on something that I'm asking you directly.

Are you saying you reset your seratonin system to a "pre MDMA" state, as in before your neurons & receptors were ever altered by substances? Or just to like a baseline that you find yourself comfortable with in between use?
 
Pre-MDMA state and it’s the other thread titled serotonin system restoration.

Taking my word at face value and not researching is stupid though. Always do your own as well
 
Vilazodone marketted as Viibyrd is so good they didn't need vowels, Also never trust a drug whose i's are too close together.

Vilazodone and MDMA is probably not a safe combination, Vilazodone already has severe warnings about serotonin syndrome which it can produce all on its own. Add in a serotonin releaser and you are playing with fire.
You rolled the dice and got lucky others may not.

Vilazodone is just a SSRI and like all the SSRIs it has a host of bad effects, whilst being only marginally more effective than placebo.
 
^I won’t address all of the inaccuracies there but it behaves much differently than most SSRI’s and has a very diverse mechanism compared to most. I’m not a fan of most of the meds in that entire class but it’s my favorite to recommend due to the mechanism.

Combining MDMA with SSRIs though is really more of a myth in terms of serotonin syndrome. Those drugs block the transporter so risk of serotonin syndrome is arguably decreased - same as using Adderall and Wellbutrin together which is done frequently and results in lessened effects from the Adderall.
 
vecktor said:
how about you do?????
Click to expand...

Well like I said, I’m generally not a fan of that medication class and view prescribing them as a last resort (I can’t prescribe them yet but will be). That said I do recognize that they are extremely beneficial for a small subset of the population with my girlfriend being one of them.

She’s struggled with depression, anxiety, and some mood disorders most of her life and I finally talked her into trying some medications. Viibryd was the second one she used and within two days she did a complete 180 and was an entirely different person.

That was about two months ago and I’ve never seen her laugh, smile, and let inconviences roll off her like since she began taking it and I’ve known her for 4 years. Legitimately a life changer for her to the point she called her doc and cried thanking him because of how much better and more stable she feels. So to say that aren’t effective is definitely inaccurate when they are given to the correct people - however they are very over prescribed. Obviously the name and spelling comment was just facetious.

As far as being an SSRI it is to some extent although it’s also a partial agonist which makes it a much better drug from what I’ve observed in pat

As far as serotonin syndrome, it’s a therorerical implication of a releasing agent and a reuptake agent but in reality a releasing agent can’t act to it’s full extent, or at all, if the 5HT transporter is blocked. Same as wellbutrin and adderall. Dance safe isn’t a particularly scientific website but they are correct in saying that an MAOI is the primary dangerous concern and that SSRIs are not. The second physician reference says the same and puts them in the “caution” category and not the “avoid” category.

There’s a lot of misinformation on the SSRI combo online but I have yet to see a single case in humans where normal doses (less than 200mg) of MDMA and an SSRI actually induced serotonin syndrome. If you happen to be able to find an actual case of it happening though then I’d definitely be interested since I’ve looked and been unable to find any.


dancesafe.org

MDMA Contraindications | DanceSafe

Medications and Health Conditions that Pose Considerable Risk to MDMA Users Known Contraindicated Medications: Monoamine Oxidase Inhibitors (MAO Inhibitors, or MAOIs) A MAO Inhibitor ("MAO" is pronounced like "cow") is a type of prescription antidepressant. Some of the more common ones include...
dancesafe.org dancesafe.org

 
Actually just finished a rotation with a noted psychiatrist and asked him a lot of these questions for validation. He happens to be a fan of Viibryd for the same reasons I am but, again, has to be prescribed very specifically and not in the typical PCP shotgun approach.
 
OK explain me this how is vilazodone so special, vilazadone is a SSRI like all the others and additionally a partial 5HT1A agonist so it is similar to buspirone in that respect, nothing special.

When I say slightly more effective than placebo I mean it, as in that was the conclusion of the clinical trials, relapse was as bad as placebo.
Anecdotally it might work for your girlfriend, I am glad. However the evidence is poor overall. How do you identify the extremely small subset where the drug is beneficial? because in every other case the drug will be giving no benefit whatsoever. First do no harm doctor.

I feel sorry that you have yet to realise that your tools are not good enough and you still forelock tug noted psychiatrists for validation.
 
It’s just the fact that there isn’t a drug out there yet that does what it does. And yes, of course there will be relapse. That class is generally one that, IMO, you can’t come off from. If it works well then it’s likely a med that those patients will continue to need.

At some point I think we will be able to treat without that class - that’s my goal always and have successfully done that for myself - but we aren’t there yet on a broad spectrum.



Either way, it doesn’t really matter. The point of this post was simply to inform people that it doesn’t block out a roll like other SSRIs which aligns with some posts I found on reddit as well. Just some insight for people who will be inevitably asking at one point or another as more people are prescribed.
 
Ty for expounding on your experience. I ofc would look further into it if I was curious, but I was looking for your personal take. So ty for that.

And ty to vektor as well for his input.
 
DopeM said:
Ty for expounding on your experience. I ofc would look further into it if I was curious, but I was looking for your personal take. So ty for that.

And ty to vektor as well for his input.
Click to expand...

The drug you are curious about is BPC-157, not viibryd but there’s additional info about it in the other thread. Amazing compound
 
Swim15 said:
The drug you are curious about is BPC-157, not viibryd but there’s additional info about it in the other thread. Amazing compound
Click to expand...

How do you take BPC? Sub Q / IM injection? in what site? I read it has virtually no bio-availability orally
 
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