Panamajack
Greenlighter
- Joined
- May 12, 2010
- Messages
- 14
I hope I'm not breaking any rules by addressing you directly. Obviously, this goes out to anyone else who might like to comment too. I have some questions about the antagonist actions of Seroquel and what those actions do to my psycology. Can't seem to find much in the literature about it and my doc. only speaks Spanish, so she's not much help. I'm determined to get free of my slavery to H, and the more I know about this detox and post w/d the better I am armed for the fight. I hope I didn't piss you off by ignoring your advice to drop the Tramadol X. I''m down to 90mg today and end with 25mg Monday. So far I'm only a little sick, thank God. Will you answer a couple of short questions?![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")
I'm adding this edit, because I'm in a time bind. Can anybody answer my basic question about how an antagonist drug like Seroquel can have any effect on you if by definition it has affinity for a receptor site, but no efficacy? See below for more detail.
First I want to see if my understanding of the basics is correct. The receptors in the brain have at least 4 states.
Normal,
Abnormally activated by an exogenous agonist, something like heroin
Stripped state Like in heroin cold turkey w/d. The dopamine, etc. receptors are left open, since the body doesn’t begin to fill them until some time later. Maybe months later. This stripped state of the receptor causes all the misery of detox and post w/d.
Blocked by an antagonist drug like Seroquel which has receptor affinity but no efficacy.
This is where I’m in the dark. What psychological and physical effect does a dopamine and serotonin antagonist with no efficacy have on you, during detox and after?
I’ve also read that the effects are dose dependent. That at low doses the histamine antagonist action is felt and that you have to take more to get the dopamine antagonist effect, and still more to affect the serotonin receptors.
Also, if I’m right about the dosing dependence on the dopamine and serotonin receptors of Seroquel (above), does that mean I need to up the dose of Seroquel to get those effects during post w/d. I’m only taking 50 mg now for insomnia.
I feel like I’m missing a very important point here about the effects of antagonist drugs. Hoping somebody can enlighten me, so when I see my doc I can tell her how I want to do this thing, and not just have to blindly follow her program.
I’m an old fart, and I’ve known excellent doctors and a couple that almost killed me. The last with a warfarin overdose, so please forgive my skepticism of doctors. No offense is meant.
Just in case anyone thinks I’m being mental and a pussy about this, I want you to know that the 1st and only other time I tried to kick this crap I did it with nothing more than a homemade dehydration mixture. I was that ignorant of what I was up against. I got so sick on day 4 that a friend of mine found me crawling down the road delirious, pants soaked in shit. He took me to our local third world clinic which is 3 hours away, and I spent 48 hrs on a rehydration IV. Thank god he found me. By that time I was almost over the worst of it. I relapsed after 20 more days of no sleep.
This time I’m going to be as informed as I can, do it right, and be successful by God!
I'm adding this edit, because I'm in a time bind. Can anybody answer my basic question about how an antagonist drug like Seroquel can have any effect on you if by definition it has affinity for a receptor site, but no efficacy? See below for more detail.
First I want to see if my understanding of the basics is correct. The receptors in the brain have at least 4 states.
Normal,
Abnormally activated by an exogenous agonist, something like heroin
Stripped state Like in heroin cold turkey w/d. The dopamine, etc. receptors are left open, since the body doesn’t begin to fill them until some time later. Maybe months later. This stripped state of the receptor causes all the misery of detox and post w/d.
Blocked by an antagonist drug like Seroquel which has receptor affinity but no efficacy.
This is where I’m in the dark. What psychological and physical effect does a dopamine and serotonin antagonist with no efficacy have on you, during detox and after?
I’ve also read that the effects are dose dependent. That at low doses the histamine antagonist action is felt and that you have to take more to get the dopamine antagonist effect, and still more to affect the serotonin receptors.
Also, if I’m right about the dosing dependence on the dopamine and serotonin receptors of Seroquel (above), does that mean I need to up the dose of Seroquel to get those effects during post w/d. I’m only taking 50 mg now for insomnia.
I feel like I’m missing a very important point here about the effects of antagonist drugs. Hoping somebody can enlighten me, so when I see my doc I can tell her how I want to do this thing, and not just have to blindly follow her program.
I’m an old fart, and I’ve known excellent doctors and a couple that almost killed me. The last with a warfarin overdose, so please forgive my skepticism of doctors. No offense is meant.
Just in case anyone thinks I’m being mental and a pussy about this, I want you to know that the 1st and only other time I tried to kick this crap I did it with nothing more than a homemade dehydration mixture. I was that ignorant of what I was up against. I got so sick on day 4 that a friend of mine found me crawling down the road delirious, pants soaked in shit. He took me to our local third world clinic which is 3 hours away, and I spent 48 hrs on a rehydration IV. Thank god he found me. By that time I was almost over the worst of it. I relapsed after 20 more days of no sleep.
This time I’m going to be as informed as I can, do it right, and be successful by God!
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.. I will tell him on yahoo there is a post for him.
