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New and relatively new RCs - Guinea Pigs queue on the left please

StretchOutAndWait said:
Update on the AH-7921 front. I took 25mg sublingually with an etizolam last night because I was in a lot of physical pain. I had also had a few martinis in the afternoon. Within about 15 mins, I was in no pain whatsoever, it was brilliant. No real euphoria but I don't care - I'd otherwise have taken 60mg DHC which would have taken the edge off but I'd still have felt it.

I also slept for 14 hours, but I'd only slept for about 2 hours a day since Thursday and this was mostly on the loo (thanks 2ci, aMT and MPA) so difficult to know whether that can be attributed to the AH.
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Interesting, what's your opioid tolerance like? (I'm sorry to hear about your pain <3)

Reports of this being caustic concerned me too, hopefully (?) it was just impurities. I might give it a whirl this week. Got to say I'm quite glad this one doesn't seem to have ridiculously low dosing unlike fentanyl analogues..
 
^ Relatively low opioid tolerance. Had a dependence on around 250mg DHC a day last year (so even then not huge) but not anymore. Slight residual tolerance left. Think I am probably in the upper quartile of CYP2D6 metabolisers - used to be able to really notice even just two generic co-codamol (i.e. 16mg codeine). Reckon now I don't notice anything lower than about 45mg but after that point it all feels much the same.

Obviously that info is not that useful without knowing the metabolic pathways of AH-2971, but I reckon that probably my sensitivity to codeine is not transferable to AH, sublingually at least (so someone who would need more oral codeine/DHC to feel the same effects as me would not need correspondingly more sublingual AH). I think this because obviously SL AH bypasses initial biotransformation in the the liver, where the majority of the CYP enzymes do their stuff. Clearly this is just speculation, though.

Sadly haven't had the chance to experiment again - been taking it easy since Sunday. Probably a heavy one this weekend as well (well, techno tonight then rave tomorrow so inevitably, really). But with a bit of luck will refrain from bashing out the AH while interactions remain completely unknown, so won't have much to report for at least few days. Would be v. interested to hear how you get on if you give it a go.
 
New possible Research Chemicals – RC´s

New possible Research Chemicals – RC´s
(Attachment: Tabular initial self tests in English)


During the „interview with a RC chemist“, it is expressed that pharmakologically reasoned proposals are searched for new Research-Chemicals with possible psychodelica character for synthesis and testing.

„War On Drugs“ will go on, and we must be possibly always one step ahead! Legalisation of the psychedelics makes progress only at a snail's pace, if at all.

I synthesized some new RC´s and made initial tests with myself. The results range from encouraging to disappointing. Details may be found in the English-written attachment.
The examples are intended as stimulations to others for further "Researches". It is important that one does not focus himself exclusively on the affinity constant K to the 5-HT2A-Receptor: higher binding affinity (smaller K value!) is not always combined with a higher psychedelic potency.

If one is interested, I can send on request (annabolaine[at]rocketmail.com) the two copies of the original literature (1.1 and 2.4MB!) I cited in the attachments (see below):
Lit.1: Schulze-Alexandru, Meike; Kovar, Karl-Artur; Vedani, Angelo (Institute of Pharmacy, University of Tubingen, 72076 Tubingen, Germany): „Quasi-atomistic Receptor Surrogates for the 5-HT2A Receptor: A 3D-QSAR* Study on Hallucinogenic Substances“, Quant. Struct.-Act. Relat. 1999, 18(6), 548-560, Wiley-VCH Verlag GmbH.
(*Quantitative Structure-Activity Relationship)
The last three sentences of this literatur: „The most promising candidate compound is a molecule which represents a hybrid structure between LSD and phenylalkylamines such as DOI. The binding affinity of this compound towards the 5-HT2A-receptor is predicted to be K=3.2 nM, close to the experimental binding affinity of LSD (Kexp=2.5 nM). Some of these compounds have been synthesized in the meantime, allowing for a critical evaluation of our model.”

(These compounds have simple structures between amphetamines and LSD. I never found any article dealing with such compounds from 1999 till 2010.)

Lit.2: Molecular Pharmacology Fast Forward. Published on September 25, 2006 as doi:10.1124 / mol.106.0287; MOL #28720:
“Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with super-potent N-benzyl phenethylamine agonists”,
Michael R. Braden, Jason C. Parrish, John C. Naylor, David E. Nichols, Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Purdue University, West Lafayette, IN 47907.
This artikel deals with the known PEA-NBOMe.

Hope, that rocketmail accepts such big attachments.
Since I am still not able to post any attachments (I am still a greenlighter), You may find them here:
http://www.pantorise.net/viewtopic.php?f=17&t=1049&p=25174&sid=2da7a3617ab422e7bc9ea7a107aba677#p25174
So long,
Hans Meyer
 
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Could you please post a link via a filesharing service? I can't look at those attachments on the other forum.
 
2-Methoxyketamine is a dissociative RC which is supposed to have very similar properties to ketamine. Very few people have used it.
 
Transform said:
2-Methoxyketamine is a dissociative RC which is supposed to have very similar properties to ketamine. Very few people have used it.
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Ahhhaa! Thought it may be. Very interested in this one, is the general consensus that its more like ketamine or does it share properties with Methoxetamine?
 
I ended up doing the Alpha-PVP last week, whole gram gone in about three days, didn't share any either.

Well, honestly I expected something better, I mean it had that semen-like taste that pv has, and having that tasty drip down my nose already made me feel decent, however overall it was a bit of a let down. It's much more mellow than pv, less straight stimulation, not much in terms of euphoria.

In the beginning I was measuring, first line was a conservative 10 mgs, less than an hour later I'd done about 70 mgs already. It left me chasing a high that I never got in the first place anyway. I had a lot of etizolam available, which I didn't have back in my pv days, so I really didn't suffer from any paranoia and/or over-stimulation.

Only snorted and dabbed, I originally wanted to chase, but when I saw the size of the lines I needed to do in order to feel something I decided against it, as the one good thing with chased pv, is the ridicolously small active amounts of material you need to inhale. Didn't want to punish my lungs smoking piles of that.

Overall I did the dishes, watched about nine hours of porn, listened to some gabber, but then I got dysphoric so I turned the music down and went back to the smut. Thing is when I finished it I had the feeling that it deserved another test as maybe, like with pv, it's an acquired taste where you need more than a couple of days on it to really understand how to enjoy it. Made another order straight away, hopefully shouldn't be too long till I can continue the experiment, also cause I downloaded a lot dodgy videos I have to watch.

Anyway, laters
 
specialspack said:
Could you please post a link via a filesharing service? I can't look at those attachments on the other forum.
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I will post a new link, which is free for attachments-download.
(Why I always be fired, when I tried to write something?)
 
You are right! First I posted "New possible Research Chemicals – RC´s (Attachment: Tabular initial self tests in English)" under AEDD, but somewhere moved it to "New (or relatively new) RCs in the UK - Volume 5". I would be glad if that could be undone.
Since I am still not able to post any attachments (I am still a greenlighter), You may find them here:

http://www.pantorise.net/viewtopic.php?f=17&t=1049

I tried to send a PM to a Mod. for correct that, but got an error, that the number of my PM is full. I give up trying to post anything else in bluelight. I am sad!
 
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Ham420 said:
Ahhhaa! Thought it may be. Very interested in this one, is the general consensus that its more like ketamine or does it share properties with Methoxetamine?
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It's been rumoured since the idea of it first surfaced that it'd be more like Ketamine, than MXE was. But of course, very few have used it, so it's all a bit unsure.
I've seen on various RC sites a release date which just kept getting pushed back and pushed back, but it looks like one has committed to it now. You can probably expect a lot of reports soon enough, could be one to look out for. :D
 
Has anyone had expierence with 'Sunshine' or MMAI..?
I recieved quite a large sample of this....not much info out there tho.
If anyone can share there expierences or thoughts on this RC,would really appreciate it.
 
AlwaysChasingIt said:
Has anyone had expierence with 'Sunshine' or MMAI..?
I recieved quite a large sample of this....not much info out there tho.
If anyone can share there expierences or thoughts on this RC,would really appreciate it.
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I'll remove your thread since it has the same question, hopefully you'll get some info here.
 
Got some camfetamine from ages ago that's still untouched (free sample).

Is it useful at all for cleaning the house like a speed freak whirlwind?
 
SamhainGrim said:
Snorted around 20-25mg allylescaline fifteen minutes or so ago.

Feeling a pleasant but not-overwhelming body high, bit of visual enhancement and a slight churning in my stomach.

Going to go for a walk shortly and see how it goes. Most reports I've read have suggested it's nothing spectacular so I'm not expecting a lot, but at present that lack of expectation seems to be paying off. We'll see.
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Couldn't give us an update could you :) allyescaline is probably one of the cooler RC's about, even if it is shit :D

Who wouldnt want to take this bad boy

200px-Allylescaline-3d-sticks.png
 
Munroe said:
Got some camfetamine from ages ago that's still untouched (free sample).

Is it useful at all for cleaning the house like a speed freak whirlwind?
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Definately. My reply is probably too late now anyway. At first i was very disapointed with it as my expectations were way too high. I left the remainder of my sample untouched for months, until i eventually turned it up again, took it with no expectations, just hoping for a slight stim lift. Got that allright, yes it was effective as a productive drug, in moderate doses, and felt pretty good too..

Was tempted to get some more, but then i tried some ephylinidate from another vendor that i was given as a free sample.

I tried this with no expecations atall as i really disliked the first and only gram of it i had possesed until then. Well i was very surprised to find myself really enjoying it second time around. So i quickly followed that up with a larger re-order. This will keep me going for a functional feel good stim for a while now. I'm not sure why the product from the 2nd vendor seems more enjoyable; i dont think it's entirely down to expectation, i think there is something different, and nicer about it.....
 
It was a while ago now that i had it, so i cant really remember tbh. As a guestimate i would have taken 100 - 250 mg (sorry thats a massive range, but i think thats the dosage range, Some one please correct me if im wrong.) you could try a 75mg bomb, see how that affects you. Its definately nothing like as super potent as PV, and you need defiantely also need more camf than you do eph weight for weight.
 
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