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Neurotoxcity of Meth

specialspack

specialspack

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May 8, 2001
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What are the seminal papers that show the neurotoxicity of meth? Is this considered a pretty solid fact of science now, or is it still controversial?
 
I haven't paid much attention to meth, but my impression was that it's in a similar situation as MDMA: Definitely neurotoxic, but it's not entirely clear if it causes significant axon loss in recreational users. There is evidence of brain atrophy in heavy long-term users. The place to dig for research would be PubMed: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

If you aren't in a university, it might be difficult to get access to the main articles themselves, although if there's something in particular you want posting a request here would probably get it.
 
 
I would also worry about the possible impurities present in the meth. Reaction byproducts, cuts and left over reagents could also be neurotoxic.
 
redeemer: you could always do a wash on your final product to clear out any impurities/cuts.

this topic interests me alot can someone please give me a very clear picture of the effects of selenium on methamphetamine neurotoxicity according to these two articles:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10082851&query_hl=5
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10642830&query_hl=5


also Bilz0r a few of those articles you had links too were from "abuse" is that too say even use of methamphetamine is damaging?
 
*shrug* meth studies are hard because meth users often IV, and take other drugs and all sirts (poor diet etc)
 
From my admittedly incomplete knowledge of and readings into the literature, it seems that meth is definitely neurotoxic at very high doses (in humans, probably a dose that would either make you physically feel like you took too much or an outright overdose), and there is evidence that "binge" administration of meth can be neurotoxic, in animals. But I would agree with Bilz0r in that the most disturbing, though indirect (because most of the studies I know of are in living people, so you can't examine the tissue directly), evidence comes from the studies of long-term meth addicts.

That said, I believe that we should take all of Ricaurte and friends' pharmacokinetic and pharmacodynamic models of "equivalent human doses" in other animals with a grain…no, a rock…of salt.
 
So 5-HT2 your saying that methamphetamine is probably not damaging used infrequently and in low doses b/c most of the studies are done on long-term addicts and to take whatever reading that hypes meth up to be damaging with a grain of salt?

Not trying to be condescending/disrespectful but is that what you meant?
 
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