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Neurochem depletion from ketamine?

I

incognition

Bluelighter
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Mar 25, 2010
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Hello, i have no clue of ketamines action besides its a NMDA receptor antagonist. I know it's not a very specific drug in its binding profile, but i guess the major player regarding my question is the NMDA-action. And the question is whether there's any theoretical way to help your brain to get back to normal functionality after use, like the way you can support recovery from amps & mdma with various nutrients and amino acids.

Like eating.. hefty amounts of MSG? No, just kidding. Any input appreciated.
 
What exactly do you mean by "getting the brain back to normal functionality"?

Now I've had my way with ketamine, and since you compare it with amphetamines and
mdma, I suspect you've experienced some sort of hangover or prolonged sideeffects?

The main reason (besides harm reduction) why you eat 5-HTP or tryptophan after and before taking MDMA is to ensure serotonin production is sufficient, so that you prevent the "tuesday bluesday" depression from the drug.

Do you experience such effects with ketamine? In what way do you feel 'inhibited' by the drug afterwards? - because I've suffered no such thing.
 
It's kind of vague, but still very noticable, and it has nothing to do with feeling low or anything. Just less sharp, light "flashbacks" of that mintyness (?) :D now and then. Something is altered, it feels like some sort of depletion. I have a feeling that it can't be that uncommon, but since its not involving depression/anxiety, it's not that interesting to talk about.
 
Well ketamine inhibits inositol production, at least in animals. Which is in part why it reverses the mood-stabilizing effects of lithium, since inositol levels are implicated in depression and bi-polar as well. You can find inositol supplements at a health food store, I find they helped me gain a greater clarity of mind after a period of K use. I know what you mean by flashbacks to that sweet minty taste at the back of your throat, it's a very seductive drug... Don't get pulled in too deep.
 
The NMDA receptor is one of the most fundamental receptor types and is probably presenton all neurones.

There may be some upregulation of the receptor because of chronic K use, but the system is in so much flux i doubt it will be having any real long lasting effect.

There may be some changes that lead the the feelings you are having, but i bet its nothing to do with NMDA receptor signalling.

Also, MSG wont do anything. increased extracellular gluatamate levels ARE NOT desirable, and your nervous system is set up to deal with this effectively.
 
fireball: Judging by my latest experiments, centrophenoxine seems to help. Are there any obvious links to acetylcholine in some way with ketamine?
 
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