Xorkoth
Bluelight Crew
Everything you’ve just quoted is decades old information. That’s been refuted many times in too many other older threads that it’s no point rehashing it here. Try finding something from the last 20yrs maybe?
In the last 20yrs we’ve discovered that polymorphs have an effect. Back then they didn’t know crystal lattice formations had an effect on the experience itself. We are just now in the past 5yrs even beginning to grasp what it all even means.
Back then they didn’t have as many ultra pure chemicals as today, as you can see in your quoted material they seem to have this misguided belief that only LSD holds potency needed to give effects. They did zero testing of the synergy between the impurities and LSD. We since now know that there can be interactions.
Great example, CBD and NMT. Both substances once thought to be pretty much inactive. But we see when combined with THC and DMT respectively there is major interactions which take place that can alter the experience.
In the end, any word on what crystal your LSD is is likely BS. And people are gonna believe what they want to believe on the purity topic.
-GC
Yeah polymorphism is a fascinating topic we are only beginning to really understand. Though it is sensible to think that the crystal structure would make no difference, since it dissolves into individual molecules before being absorbed, that does not seem to be the case, at least not always. The smoking gun for me came when I read about an HIV medication which only works with one of the polymorphs, and is ineffective with others. Quite simply, I think we think we know more than we actually do. Clearly there is some factor in the molecular structure that is different between different polymorphs, otherwise why would they form different crystal structures? It is not hard for me to believe that these differences could in some cases at least, have an effect on the way the molecule behaves in the human brain in terms of receptor binding and/or other factors. The fact of the matter is, interaction with drugs and receptors, and the resulting subjective effects, is an extremely complex thing, and I believe we simply do not yet fully understand everything that is going on.
Of course the placebo effect is also a very big factor. But one polymorph of an antiviral drug working and others not working is no placebo effect. There is something there and that is concrete evidence that polymorphism at least CAN, in some cases, have a profound effect on the effects of a drug.