N&PD Moderators: Skorpio | someguyontheinternet
Magnesium will cause psychological effects in high doses, anaesthesia after that, and slightly further than that level you get a lot of organ/brain damage assumably through respiratory failure and hypoxia.
Jamshyd said:Hey all,
No, I am not asking for a dissociative that I can find growing on trees. lol.
What I am asking for is...
Are there any drugs or peptides found in nature that cause NMDA antagonism?
Of course, that is barring Ibogaine, Mg and Zn.
Any input would be appreciated.
I have searched a lot and couldn't find what I'm thinking about. I am aware though that I usually look in the wrong places :D
Again, I don't care if it gets you high or not - I am simply interested in naturally occuring compounds that are NMDA antagonists.
It puts you to sleep. Feels GABAergic to me.one day I would like to try an excessively high dose of theanine, jus to see what it can actually do.
I take a standardized extract of Huperzine A 200 mcg twice daily as a cholinergic memory booster. If it has any dissociative NMDA-antagonist effects, then they sure have eluded me. lol
It puts you to sleep. Feels GABAergic to me.
Theanine is an antagonist of the following Glutamate receptors: AMPA, Kainate, and NMDA.
L-Huperzine A is also a NMDA antagonist.
Nitrous oxide and ibogaine are NDMA antagonists.
Kynurenic acid is a antagonist at glycine site of the NMDA receptor.
Kynurenic acid is a bad chemical for humans, it's associated with schizophrenia. the other chemicals mentioned are fine.
At double the recommended dose, it seems to have the same effect as DXM (anti-depressant wise). At higher doses it starts manifesting some weak dissociative signature, also similar to DXM, but I am happy with Ketamine as a dissociative of choice and will not be trying Cat's Claw "recreationally".
The beta-carboline constituents of Syrian rue seeds, above all Harmine and Harmaline, arose in some research suspicion of being active at the NMDA receptor, beside being potent MAO inhibitors. Bioassay results are in favour of this, but given the MAO inhibition, things unsurprisingly get nasty once clear signs of dissociation become appreciable. A Moclobemide control against this also produced results in favour of harmala activity beyond MAO inhibition.
An interesting experience to say the least, but careful proceeding is warranted.