Opioids Naloxone / oxycontin

[eamonshort]

Hey guys, wondering if Targin is equitable to sustained release oxycontin. Not planning on crushing or anything, Like to use 60mg endone for a nice come up and take it with 60mg oxycontin SR uncrushed to keep it going, is 60mg Targin equal to 60mg oxycontin, does the naloxone impact the high at all?

 

[flyhighk]

They just add naloxone to prevent people from injecting the pills, i think.

 

[mastersofine]

At worst it could give you a headache if you are sensitive to naloxone. I am on subutex now but I was on suboxone which has naloxone in it and it gave me gnarly migraines.

 

[Lorne???]

The bioavailability of nalaxone Administered orally is less than 1%, it isn't absorbed into the blood stream at regular doses, it's useless.

Yeah, it's equal to any pure oxycodone product. Have fun.

(Don't snort it! Nalaxone is active that way...)

 

[Lorne???]

They just add naloxone to prevent people from injecting the pills, i think.

The official reason is to prevent constipation. And indeed, it is effective for this purpose.

In the same way that loperamide is effective because the bioavailability is so extremely low, so is oral nalaxone. In both cases you have BA's of 1% or less(at regular doses) so it does it's intended purpose without entering systemic circulation.

Of course. nalaxone has the gnarly side effect of preventing IV use(mostly) , but that is just an "unintended side effect".