N--(p-Methoxyphenyl)-2-Methylpiperazine

[kidamnesiac]

Expect a few of these threads, I'm helping to clean out a choline-studying lab.

Is basically MeOPP or whatever it is, the sedative piperazine, but with a methyl group on the piperazine ring, reminiscent of amphetamine. I've managed to find zero usable info on this one.

Any info from the vaults that be the brains here?

I'd post the structure but java hates linux

 

[Reminisant B]

Personally I wouldn't go near it simply because adding a methyl group to the phenyl-piperazine part of the structure is one more step closer to MPTP.


This however isn't based on any actual information/studies etc just my 2 cents. It will probably be a completely different compound that is the next MPTP but it doesn't stop structures which shares similarities to MPTP ringing huge alarm bells in my mind.

 

[Riemann Zeta]

I'm not sure if it is equivalent to MPTP, as the methyl group is at position 2 on the piperazine ring, not on the terminal nitrogen--hence, it hopefully wouldn't form a quartinary pyridium ion. That said, however, piperazines usually suck ass in terms of psychical effect, so I doubt it would be worth trying.

 

[Reminisant B]

[EDIT] Sorry I was thinking the compound was N-methyl not 2-methyl so "one step closer to MPTP" is not correct.

 

[MattPsy]

They have, i've tried 4-methyl-1-benzylpiperazine, doses between 100 and 400 milligrams.
It most certainly hasn't given me Parkinsons... nor the many others who have tried it, often in combination with BZP and TFMPP (it has been sold as one of the actives in "party pills", in my home country, New Zealand).

Anyway, I think it will be safe to consume, but will probably suck as a recreational drug.

 

[Reminisant B]

^ That's N-Methyl-BENZYL-piperazine or 4-methyl-BENZYL-piperazine.

PHENYL-piperazine(s) are entirely different and only substituted phenylpiperazines are included in party pills(MCPP, MEOPP etc). PHENYL-piperazine itself is quite a toxic compound (not MPTP toxic just horrible for other reasons) and NOT the same as BENZYL-piperazine. [One trip report on erowid suggests they are but this is definately not true ]


Agreed N--(p-Methoxyphenyl)-2-Methylpiperazine is most similar to MEOPP (which is in party pills) and is substituted but what's a safe substitution on BENZYL-piperazine(s) cannot automatically be transferred to PHENYL-piperazines.

 

[MattPsy]

I know they're different but I consider it evidence towards it's safety anyway.

I believe F&B is quite familiar with the mechanism of both MPTP's mode of toxicity as well as the structural features that cause it - hopefully he can chime in here.

Anyway, there is evidence that a 2-Me on the ring would block MPTP-like activity.
Synthesis and Toxicity toward Nigrostriatal Dopamine Neurons of 1-Methyl-1-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Analogues
J. Med. Chem. 1986,29, 424-427

Compound 2 posesses a methyl group next to where the phenyl ring would join the OP's compound, except in this paper's case 1) the Ph-N nitrogen is missing (as it's not a piperazine ring, it's a close MPTP analog) and 2) the ring isn't fully saturated (again, as per the last bracketed point).
There was no observable loss of DA, DOPAC, or HVA.

 

[Reminisant B]

Definately agreed about not being MPTP, that was MY ERROR as I thought the compound in question was N-methyl (the compound in question is 2-methyl) and all I was suggesting was it was one step TOWARDS MPTP (the other steps being loss of first nitrogen and unsaturating certain bonds) which WOULD have made ME nervous.


I don't see how N-methyl-BZP can be used as evidence to suggest safety of 2-methyl- PHENYL-piperazines as they are completely different [Firstly it's PHENYL-piperazine and secondly it's 2-methyl not N- or 4-methyl]

 

[MattPsy]

Yeah i'm not even sure why i did now either. ;/ i withdraw that statement about MBZP.
My basis of argument for the safety of the OP's compound is now the paper I referenced.
And of course the fact it's not N-Me as you say. So yeah, little to worry about here.

 

[Reminisant B]

^Yeah

There are a few patents on disubst-phenyl-2-methyl-piperazines for the treatment of "5HT2C associated diseases" but seeing as there is no info on them I would still tread carefully - most drugs which include a piperazine ring don't have that 2-methyl substitution.


On a completely different piperazine topic:

I know 2C-B-BZP has been discussed quite a lot on bluelight, doesn't have any hallucinogenic properties(BZP being bad PEA mimic) - mostly stimulant properties with side effects.

WELL random bit of information: What would be the [EDIT] isomescaline-BZP equivalent is actually a licensed angina medicine - Trimetazidine. (other bluelighters may already know this compound but I hadn't seen this one and was quite surprised)

http://en.wikipedia.org/wiki/Trimetazidine

 

[MattPsy]

Close but no cigar - mescaline has a 3,4,5 substitution pattern. Trimetazidine has a 2,3,4 substitution pattern.

 

[Reminisant B]

^good point.

isomescaline-BZP equivalent? I'll edit my post.

oh and isomescaline produces very little effects so not so interesting fact. no cigar indeed!