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N,N-diethylfencamfamine

pubchem.ncbi.nlm.nih.gov

N,N-Diethyl-3-phenylbicyclo[2.2.1]heptan-2-amine

N,N-Diethyl-3-phenylbicyclo[2.2.1]heptan-2-amine | C17H25N | CID 154102704 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
pubchem.ncbi.nlm.nih.gov pubchem.ncbi.nlm.nih.gov

Not one person consulted PubMed. It's known, their are patents discussing it's action.
 
I loved Camfetamine back in 2012, many people were disappointed because of way too high expectations set by the ads from vendors making it look like the new meth-coke-meph hybrid it simply isn't.

It's a very functional compound, pure dopamine and very mild on the body, according to the original patent those norbornane compounds can even lower blood pressure instead of increasing it.

I would imagine something like this to be perfect for a coke-replacement combo as you can combine it with some serotonin-replacement as well as noradrenaline affecting compounds.

It also goes very well with opioids and I liked combining it with (desmethyl-)tramadol, it gave the tram the missing dopamine in the (s)nri profile.

Maybe putting an ester somewhere could make it more coke-like or similar enough to compounds like Tilidine to boost the opioid qualities?
 
I cannot find a decent QSAR study but here is an index reference:

link.springer.com

An improved synthesis of N-(3-phenylbicyclo[2.2.1]-yl)-N-ethylamine hydrochloride (Fencamfamine) - Pharmaceutical Chemistry Journal

We describe here a new and efficient method for synthesis of N-(3-phenyl[2.2.1]bicyclohept-2-yl)-N-ethylamine hydrochloride (Fencamfamine), based on the reduction of trans-5-nitro-6-phenylbicyclo[2.2.1]hept-2-ene with Raney alloy mixed with aqueous NaOH and tetrahydrofuran followed by...
link.springer.com link.springer.com

If you look at the citations and all the articles that cite THIS reference, you find ALL the references.
 
I am on 60 mg, I stocked up a bit and have been enjoying it, mixes well with cyclazodone.
 
Funny. I found some 4-pmpd recently, and was thinking about how weird and mostly unpleasant diethylfencamfamine was when I tried it. I got it from the same, now defunct, vendor. It made me feel foggy, and had a noticeable crash when it wore off. I’ve noticed it has become available again, along with 4-pmpd, so I’m curious as to other people’s experiences with it. I still have a few grams sitting around, and it it felt very nonfunctional to me, so I haven’t resampled it again. I’d be curious to hear if you found any value in it alone. I suspect the cyclazodone might be masking its “dissociative” effect (brain fog). As far as the 4-pmpd, it actually has some good qualities. I liked bzp, though it felt harsh. 4-pmpd is much less so.
 
MsDiz said:
All my rats died on the study I did with fencamfamine. I’ve lots of data but none useful for you because you’re human.
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That's pretty damned DAT selective! 😂

A BLer studied phenmetrazine isomers as their master's thesis and had just the same problem.

Tab striped bar once for small quantity of food
Tap spotted bar two hundred times for a small hit of the drug.

Results - rats all died of starvation, chronic toxicity or plain organ collapse!
 
BTW has anyone else tried overlaying camfentamine (the N-methyl homologue of fencamfamine) with nortilidine or even better, the 'reversed-ester' of nortilidine which in fact has a cyclopentane ring rather than a cyclohexene ring.

Because they overlay almost PERFECTLY except that camfentamine does not have the ethyl carboxylate or it's reversed (propionoxy) ester.

Now nortilidine (and by extension it's 'reversed ester') have four stereoisomers BUT it's the trans-pair that is used medically. One is a classic MOR ligand and a bioisostere of phenylcyclopropamine, the other proports to be an NMDA antagonst. But due to how old they both are and the fact that they are not potent means that while nortilidine DID briefly turn up in Germany, the makers were quickly caught. They pretended that nortilidine was merely an intermediate in the synthesis of tilidine - not the MORE ACTIVE metabolite.

I DID look if a nitrile (so onto the carboxylic acid and thence the ethyl ester) OR a hydroxyl on the benzylic carbon were possible. Could not find a route that made it worth all of the bother.

This is the problem with legally controlling drugs. It means that the most profitable drug of a given class will always be preferred.

As if someething 'only' 23x morphine isn't worth the trouble of making (one step).
 
I went up to 150 mg today, definitely stimulating, probably gonna do the same again tomorrow and / or Saturday.
 
blowjay said:
I went up to 150 mg today, definitely stimulating, probably gonna do the same again tomorrow and / or Saturday.
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My god, camfentamine was fully active at 10mg.

Is it possible that N-dealylation yields fencamfamine and it's the metabolites that are the actives?
 
Well, I dug out my old stash and tried 30 mg. The first 2 hours it felt weird, a little I like a mild dissociative, then became a functional stimulant. Took a while to wear off and kept me from sleeping, albeit I took it in the afternoon. Took 20 mg the next day, and again, that spaced out, foggy-headed feeling for the first 2-3 hours. After that, just a stimulant. An odd thing is that I didn’t need to take Kratom in the morning. Come 3pm, still no withdrawal symptoms. Normally I dose around 9am. Guess that supports some binding of opiate receptors. Maybe the parent compound binds MOR and/or KOR, and the metabolite (fencamfamine?) is the stimulant?
Still not that great in my opinion, and I don’t have a stimulant tolerance so I’m not interested in pushing the dose, but might be good for off days when I need some motivation.
 
General alcazar said:
Well, I dug out my old stash and tried 30 mg. The first 2 hours it felt weird, a little I like a mild dissociative, then became a functional stimulant. Took a while to wear off and kept me from sleeping, albeit I took it in the afternoon. Took 20 mg the next day, and again, that spaced out, foggy-headed feeling for the first 2-3 hours. After that, just a stimulant. An odd thing is that I didn’t need to take Kratom in the morning. Come 3pm, still no withdrawal symptoms. Normally I dose around 9am. Guess that supports some binding of opiate receptors. Maybe the parent compound binds MOR and/or KOR, and the metabolite (fencamfamine?) is the stimulant?
Still not that great in my opinion, and I don’t have a stimulant tolerance so I’m not interested in pushing the dose, but might be good for off days when I need some motivation.
Click to expand...
wait, no withdrawls for kratom?
 
So... I have some N,N-diethylfencamfamine and I was wondering if someone could give me some straight forwards dosage recommendations and expectations of the effects + duration?? I know that everyone can have a different type of experience regardless. 🤷🏻
 
First dose 25mg @ around 9:30am I then worked from the hours 11am- 3pm following which I realized that my day went by exceptionally quick; despite the fact that it was a particularly slow day. That is an effect that I will experience if I take kratom while I work... So! Since I realized that there was a little something there I decided that I would take a chance and take another dose. @ about 4- 4:30pm I took 60mg following which I noticed that my mood was, not distinctly but overall, improved; & that I was being a little more fun then usual. It was comparable to a low-moderate dose of kratom with the addition of some moderate but very noticeable sexual enticement. It is now the following morning and I have again taken a 60mg dose @ approximately 9:15am it is now 9:30am I had another shift at work 11am- 3pm. It was busier then expected and I was a bit more on the ball then usual for most of the shift; feeling more mentally organized and it was easier to exhibit confidence as I interacted with my bosses and peers... Until 2:15, 2:30-ish I became noticably irritable. This suggests to me that the duration of positive effects from a 60mg dose lasts for about 5 hours (for me) prior to the comedown irritability.
Now let me tell you my overall thoughts; I find the effects to be overall very subtle. The cognitive enhancements feel far more organic than at all drug like (with disregard to the irritability that came when the positive effects dissipated...) Since it was still early enough in the day I took another dose of 90mg @ around 3:15- 3:30 it has been about an hour but I haven't had a chance to gauge the effects from this dosage yet.

I imagine that the loss of potency when compared to the parent compound of the n,n diethyl form allow this dosage range to be primarily ones alike lower doses of the original fencamfamine. I read somethings about it being an opioid/ nmda antagonist at low doses. Maybe I will discover that my most recent dosage of 90mg ventures into stimulant range, but I don't know yet.

I will probably report back here in case someone will find this information useful. (I know that I would have liked to read something like this from someone else's experiments prior to beginning my own.)
 
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