Hey thanks for putting this up , it's not taught a whole lot in med school and seems to only be a GP who knows about it when patients such as yourself come in
at least you have someone you see regularly, as I can imagine walking in with all those symptoms and past exp with meds would be pretty daunting for a 15 min GP consult.
Seroquel has agitation as a big complaint as you said, so curious to know if this helps.
and Mr Blonde's comments are true about NSAIDS, but you had no positive effects anyhow, so that's that over
here's an excerpt from the GP bible on RSL, may or may not help.
RLS, also known as Ekbom's syndrome, is a rather common movement disorder of the nervous system where the legs feel as though they want to exercise or move when the body is trying to rest. The major complaint of sufferers is of disruption both to sleep and of relaxing activities, such as watching television or reading a book. Prolonged car or airplane travel can be difficult.
RLS is frequently an undiagnosed disorder because people often don't complain about it to their doctor. A Canadian study reported that 15% of people sampled reported ‘leg restlessness’ at bedtime.
The diagnosis is made from the history - there are no special diagnostic tests.
Its prevalence increases with age so it mainly affects elderly people. Women are more prone to get RLS and it is aggravated by pregnancy. The exact cause of primary RLS is not clear. It is not related to exercise and does not appear to follow strenuous exercise.
Symptoms
There is an urge to move legs upon resting, particularly after retiring to bed. This urge is a response to unpleasant sensations in the legs, especially in the calves. The sensations are commonly and variously described as crawling, creeping, prickly, tingling, itching, con-tractions, burning, pulling or tugging, electric shock-like. However, sometimes patients are unable to describe the sensation or refer to it as simply a compulsion to move the legs.
In some patients the arms are affected in a similar way. The symptoms seem to be aggravated by warmth or heat. Many patients with RLS also experience nocturnal myoclonus.
Secondary (medical) causes include:
anaemia
iron deficiency
uraemia
hypothyroidism
pregnancy (usually ceases within weeks of delivery)
drugs (e.g. antihistamines, antiemetics, selective antidepressants, lithium, selective major tranquillisers and antihypertensives)
Management
Iron studies should be performed and, if low, treat with iron and vitamin C tablets. Advise patients that although RLS can come and go for years it usually responds well to treatment.
Self-help advice
Perform activities that can reduce symptoms, for example, a modest amount of walking before bedtime, massage or prescribed exercises (see Figure 71.6). Note: Getting out of bed and going for a walk or run does not seem to help RLS.
Click for larger image
Figure 71.6 Stretching exercises for restless legs
Good sleep hygiene, namely regular sleeping hours, gradual relaxation at bedtime, avoidance of non-sleep activities in bed (e.g. reading, eating).
Diet: follow a very healthy diet. Avoid caffeine drinks, smoking and alcohol.
Try keeping the legs cooler than the body for sleeping.
Exercises: a popular treatment is gentle stretching of the legs, particularly of the hamstring and calf muscles for at least 5 minutes before retiring. This can be done by using a wide crepe bandage, scarf or other length of material around the foot to stretch and then relax the legs (as shown in Figure 71.6).
Pharmacological treatment
The following may be effective if simple measures fail:
paracetamol 1000 mg (o) nocte or
clonazepam 1 mg (o) 1 hour before retiring or
paracetamol 1000 mg (o) plus clonazepam 1 mg or diazepam 5 mg
Levodopa, gabapentin, codeine, baclofen and propranolol may be helpful. Carbamazepine, quinine, antipsychotics (avoid), antihistamines (avoid) and antidepressants are generally unhelpful.
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the tubigrip might not be for 'compartment syndrome' esp since you don't add pressure to compartment syndrome, you release it. but prob it is to help lymph up the legs to relieve over all swelling.
take care
![:\](https://bluelight.org/xf/BL_Images/Orig_Emoji/wrygrin.gif "wry grin :\")