Sorry for my late reply guys, I was very busy with work which prevented me with keeping up with the posts and PMs here. I didn't ignore anyone.
@Skorpio
Hey no need to apologize. It is
I who should be apologizing for violating the forum rules, not you for keeping to them. Also, I think those who are seriously interested have already bookmarked my blog and that is good enough. I never intended to reach the masses, only a few passionate opioid chemistry enthusiasts. I hope you got something out of it.
@mirsNeedsHisItch
If you could Synthesize Benzos into having a opioid high you'd win a Nobel peace prize
A nobel price for a combination that influences TIs in an unpredictable fashion and therefore won't be prescribed by any doctor. It might have recreational usefulness, although I personally never liked mixing benzos with opioids as the benzo essentially kills of the euphoria for me. The only times I ever used benzos (diazepam) was to kill off the terrible panic attacks during my past opioid withdrawals.
@4DQSAR
would also contend that benzodiazepine dependence can be every bit as bad as opioid dependence
It is MUCH worse according to what I have heard benzo addicts say. It also comes and goes in waves which makes benzo wds especially grueling. I have a strong antipathy for this class of drugs and GABAergic drugs in general as they have a terribly degenerative effect on memory and intelligence, both faculties of the mind which I very much appreciate and depend on. I still remember how after three days of continuous diazepam use it already started to affect my mind negatively. I would forget things that I normally never forget, formulating sentences became uncharacteristically difficult, etc.
All of this usually lasted for two weeks after those 3 day binges to manage the wd induced panic attacks. This either means that I reacted hypersensitively towards benzos, or it goes to show how incredibly bad this class of drugs is for your brain. Probably both I'd say. I don't know a single benzo addict who has good memory or whose fluid intelligence hasn't suffered tremendously over the years. Opioids don't do any of that. They just get you hooked, that's it.
@LucidSDreamr
nice blog,
Re that published paper linked there, I do t believe for one second that that morphine mannoside doesn’t cause tolerance.
Thanks for the compliment and I hope you learned something from it (and especially the "chemistry of opioids" article which will be a lifelong work of mine). Regarding the glucomorphine: That's the problem with animal testing. What applies to animals might not apply to humans, which is why I have stated that I must bioassay this agonist on myself. We might share 99% of our genes with some animals but it's that 1% that is critical and gives different results.
Ofc my mind says the agonist will with 95% cause at least slowed tolerance increase, but my inner junky hopes that the claim of the researches translates to human subjects. It would be revolutionary too although it stands to question whether pharmacomps will want to market such an agonist as it is primarily the out of control tolerance growth in chronic pain patients that drives their revenue in the opioid market.
@CavernsoftheMind
That was a great read, thanks! I'd be interested in novel mitragynin derivatives.
I hope you're working towards an OiHKAL! (Also a good name for a punk band).
Thank you very much for your compliment. Oh I thought about mitragynin derivatives, but there are two problems for me that make that pursuit rather unattractive: a) mitragynin is quite a complex molecule and its Quant/Qual-SAR is still in its infancy (hmmm, shouldn't that actually make research into it all the more attractive for me? Maybe I'm lazy haha) and b) the long-term health effects of mitragynin are badly researched. It is unclear whether the hepatotoxicity of which some people have complained is actually due to mitragynin or some other compound in Kratom plants, but there is a theory out there that states that some people lack an enzyme for Kratom alkaloids and that is what is causing the hepatotoxicity in chronic, heavy Kratom use. I wouldn't discount that theory too quickly out of love for the plant that some might have.
So those are the reasons that makes research into Kratom alkaloids unattractive to me. Maybe some day, but not right now. Sorry if that disappoints you.
About the Pihkal: you suggest I should write a book about opioids in the style of Pihkal? I did not think about that, but it's an interesting idea. Maybe one day when I have invented two or three useful and interesting opioid derivatives that achieve what I aim for, I will be publishing those results in a book (hopefully my Tilidine derivative makes it into it. My wistar rat tests suggest an implied potency of approximately x9 (SC) but we all know that human results often deviate strongly from those animal results. Also, even if it checks my potency box, it doesn't say anything about the euphoric response which is my actual goal. I need to first and foremost find out if the Tilidine derivative has at least maintained the powerful euphoria that is so incredibly popular among german opioid users. If positive, that alone would be a major improvement as it would make Tilidine itself redundant. High tolerance would no longer be a hindrance in reaping the benefits of Tilis because the downside of this actually wonderful agonist has always been the quick disappearance of both analgesia and euphoria as soon as you have acquired even a bit of tolerance. So let's hope my Tili project will be a success. If it is you can expect a massive, multi-part blog post covering everything not in my patent, from the pics of my synthesis, exact rat testing procedures, human bioassays up to a little crystallographic analysis if my budget allows. So stay tuned for it...
