There are no studies, people don't spend money to find out things like this but I can give you examples:
http://www.drugs-forum.com/forum/showthread.php?t=172793
In the above example, the OP redosed a low dose of Adderall afraid that he/she might not be able to sleep. The low dose caused a migraine and the user thought it was the combination with tramadol.
http://www.addforums.com/forums/showthread.php?t=48248
Above is another user who got prescribed Adderall doses that are too low. As usual, the insufficient dose caused a migraine.
There's 2 known ways to trigger a migraine with amphetamines:
1) Take a low dose the first time (2-5mg dex equivalent)
2) Redose a low dose after an adequate dose. For example, taking 3mgIR, 4 hours after taking 10mgIR.
I rarely say things without basis. Low doses can trigger a migraine, and, if this is the case, then a bigger dose of the stimulant (4x more) is the BEST painkiller. The BEST:
It's as good as IV Dilaudid, because it goes to the root of the problem and solves the imbalance.
In the first case how could they rule out the combination with tramadol as being the cause of the migraine. I have read (and experienced) far more cases of high doses of amphetamines causing migraines, so I don't think it's a good idea to say to take more. I also don't see how if a small dose causes a headache it would be best to take more. It doesn't really make sense to me. You are essentially saying that if you experience this negative side effect from the drug, take more of it. Dehydration, bruxism (clenching of the jaw), not eating due to loss of appetite, elevated body temperature, vasoconstriction, and several other side effects contribute to these headaches, so that's why I don't get how doing more helps.
You say it's the best pain killer because it goes to the root of the problem and solves the imbalance, so if a low dose causes it (making it the problem) then how does a higher dose become the solution?
