My friends 15 and does 25-I NBOME at least 7 times a week

[thesixpixelkid]

As an update everyone's nodded me off as a liar, well I tried that's how I feel about it. Some of the more intelligent people on the matter didn't want me telling people that, aka the dealers. So I guess that shows how things are.

 

[Transform]

Please remember that we don't permit specific price discussion in PD

 

[atara]

So the important thing to remember is that even though the primary effects of psychedelics are roughly uniform across the class, the side-effects are very very different. For instance LSD has significant affinity for the 5-ht16 and D3 receptors, which contributes significantly to its side-effect profile at very high doses, but other compounds lack affinity here. Similarly is 5-MeO-DiPT a reasonably potent 5-ht reuptake inhibitor, which may account for increased severity of overdosing this tryptamine. Piperazines have high intrinsic activity at 5-ht2c and often 5-ht3 which contributes to a nasty side-effect profile. Et cetera.

There is a body of evidence that mescaline, psilocin, MDMA and LSD are safe under typical usage conditions. There is extensive evidence that mescaline is safe under a very wide variety of usage conditions. Other than this long-term safety of any psychedelic is very much an open question, and cannot be easily predicted.

25I-NBOMe might be a 5-ht2b agonist with similar potency to its 5-ht2a affinity. This is bad: with chronic usage may contribute to cardiac fibrosis and pulmonary hypertension. Cocaine is like that: it's primary effect (psychedelic : stimulant) is much less damaging than its secondary effect : hypertensive : anesthetic). See:

http://www.bluelight.ru/vb/threads/670462-N-benzyl-phens-may-not-be-as-selective-as-we-once-believed

 

[ebola?]

So then we wouldn't expect the same rapid receptor downregulation with non-5ht2a receptor subtypes? I mean, this kid's presumably continuing to yield effects from the compound.

ebola