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Misc mulungu toxicity?

deruyityn said:
I read this other article, by the same guys who did the other onion study, now doing a 180 saying its actually genoprotective. Im not sure I understand what they are saying how in one part it is genotoxic but then it is also genoprotective. How can dna pull itself apart and put itself back together again like that?:

http://www.scielo.br/scielo.php?pid=S0102-695X2013000200011&script=sci_arttext
Click to expand...
DNA is constantly being snipped apart and reassembled by its own enzymes (it's actually necessary for copying/transcribing DNA, and therefore necessary for life), so it's not unusual at all. There's also many different ways in which a molecule can affect DNA, and with a plant like this, there are possibly hundreds of unique molecules present that can all have their own unique effects.

So with all that in mind, it would seem like it should be way more unusual for a plant like this to ONLY have genoprotective or genotoxic effects. What's more important than anything else would ultimately be the NET effect it has on DNA (ie, is it protective enough that it more than makes up for whatever damage it can cause? If so, the plant as a whole can be viewed as genoprotective.)
 
emjay said:
DNA is constantly being snipped apart and reassembled by its own enzymes (it's actually necessary for copying/transcribing DNA, and therefore necessary for life), so it's not unusual at all. There's also many different ways in which a molecule can affect DNA, and with a plant like this, there are possibly hundreds of unique molecules present that can all have their own unique effects.

So with all that in mind, it would seem like it should be way more unusual for a plant like this to ONLY have genoprotective or genotoxic effects. What's more important than anything else would ultimately be the NET effect it has on DNA (ie, is it protective enough that it more than makes up for whatever damage it can cause? If so, the plant as a whole can be viewed as genoprotective.)
Click to expand...

That is what I gathered from the last link's conclusion; that overall the protective effect overrides the genotoxic effect.

Do all drugs mess with the dna or only some of them?
 
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