There appears to be some conjecture regarding the bioavailability of rectally-administered Morphine. For that matter, routes of administration with Morphine could qualify as unusual. For instance, insufflation of Morphine leads to a significantly reduced bioavailability, which we know flouts the typical; insufflation often being twice as potent as oral administration, as say with Heroin, Morphine's close chemical relative.
I've read reference material stating Morphine has a higher bioavailability by the rectal route. I will say that in my experience, I never found the rectal route to be significantly stronger. If I had to shoot from the hip, based on my experience and what I've read, I'm guessing there is a small increase in bioavailability from the oral route to the rectal route, say maybe 20% or something. It was never an increase that I was able to truly perceive.
However, I think all Opioids are better rectally. I don't care. I'll tell the whole world. Yes, I understand full well that this makes me gay. I've come to terms with that. I've told my Father and my Girlfriend, both of whom were disappointed.
Seriously though, the feeling of using Opioids rectally is different. I'm going to get a little abstract here, so try to follow me. When you consume an Opioid orally, it has to travel through the whole factory of our body and then the effects come on kind of slowly, maybe you notice a twinge of an itch on the tip of your nose, you feel a little bit lighter... I'm not trying to write junkie porn, I promise. When you use an Opioid rectally, it's like it radiates from your abdomen as it then radiates throughout your body. It's like an added bonus of a physical sensation that I find pretty great.
