• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Opioids Morphine during GBL withdrawal gave little to no effect despite no tolerance, until..

K

Ketobemidone

Greenlighter
Joined
Nov 6, 2012
Messages
7
Hi,

The last three weeks i have been using about 15-20ml of GBL a day. It takes about 2-2,5 hours for withdrawal to start creeping up and gets progressively worse as time goes by.

So today when i woke up it had been 3 hours since my last dose, i spent another 2 hours on my computer - making it 5 hours since my last dose. At this point i injected 50mg of morphine (i have no tolerance at all right now) and thought it was odd that the kick was so weak for a dose that would have me consumed by pins and needles at this tolerance; except this time. Right away after this i decided i would take 1ml of GBL (a very small dose, as i usually dose about 1.6ml).

It should be noted that i don't feel much taking GBL anymore, i just get rid of all my anxiety and social anxiety and become more active/talkative. I don't feel high.

So about 20 minutes after this 1ml dose my GBL withdrawal symptoms mostly passed and at the same time i start feeling the opiate high, and i'm feeling pretty good.

2 hours later i can't feel the morphine at all anymore and the GBL withdrawal starts creeping up on me, but not as bad as it usually does. 6 hours after injecing the morphine, after going to school and coming back home again, i take my usual dose of GBL (1.6ml) and within 15 minutes i feel the GBL effects vaguely and amazingly enough my morphine high is back from the dead and is getting stronger by the second, additionally my mouth and sinuses are getting real dried up for the first time.

1 hour after taking the GBL i am feeling the effects of the morphine very strongly, and this is almost 7 hours after it was injected.


Can anyone explain why this is? I felt absolutely no effects of the morphine 2 hours after dosing and 7 hours and a GBL dose later i feel it very strongly.

What could be the possible pharmacology behind this? Does it have something to do with dopamine?

Thankful for answers!
 
I should add that the same thing happened when i shot zolpidem. During GBL withdrawal i shot 3x25mg zolpidem and didn't get that much of an effect. The next day i took my dose of GBL and then shot 20mg of zolpidem and got a better and trippier effect than from the 3 consecutive shots of 25mg zolpidem.
 
The GBL withdrawal was simply masking the affect of the morphine?

(GBL is a prodrug to GHB.. very nice drug but addiction is seriously hard to avoid and withdrawal is hell)
 
It turns into GHB in the body and is absorbed across the BBB faster than if you were to take just GHB.. Doesn't have opioid affects / properties..

It's neither RX or street, really :\ It's easily found online..

Do your research before you delve into it though.. there's plenty of information out there.. I believe it's calles Gamma-butyrolactone..

Take it from someone who has been addicted to this multiple time.. It's SOOOO easy to dose 24 / 7.. You really don't wanna start doing that.. you will not be able to sleep without it in no time and physical addiction will start to occur in as little as 1 - 2 weeks of this kind of use.. withdrawals are fckin nasty.
 
i too didn't feel much from opiates when in GHB withdrawal. i'm not sure what the pharmacology behind it is. opiates and G is a bad mix, experimenting like that sounds tricky, take care. G withdrawals, as you may know, are intense but short.
 
How long have you been taking GBL?

Withdrawal starting 2.5 hours after your last dose of 1.6ml leads me to think your withdrawals will be very short lived and pretty damn mild.. I've had withdrawals start 1 hour after 2ml dosing in the past but the most recent time was about 1.5 hours after a 1.7ish dose.. and the withdrawals sucked for day 1 - 2 or 3 but then i was pretty much back to normal by day 5 or 6.. I'd just quit now if i were you.
 
GABAergic system is very fundamental in our brains (by calming down) and opiates have synergy with GABA. Alltough this is interesting in case of GBL because GABA-b receptor (GBL effects gaba-b) might have influeced negatively on opioids effects but gaba-a instead positively. If I remember correctly, opiate high is partly making GABA-b (or maybe both) receptors hypofunctional. Someone might correct me, I don't have time to check that.

Anyway, I have experience with GABAergic withdrawals and alltough I have had some minor withdrawals from GBL years ago I didn't try any opioid then. Recently I've had experience with Phenibut with it is pretty similar to GBL at some effects. And its withdrawals completely inhibits any codeine high. I just didn't feel good on it.

Partly I believe this becomes because of excacerbated adrenergic signaling during withdrawals (adrenaline noradrenaline). I have experienced similar situation when I had took clenbuterol (beta-adrenergic agonist) and took xanax and codeine. I didn't feel much of anything relaxing.

So basically GBL withdrawal is just making you overly stimulated physically and that I believe is a big part of explanation. And also opiates are potentiated because GABA and you could simple think they are then inhibited by lack of GABA in withdrawals.
 
^ Phenibut withdrawals were the worst for me.. i was using it daily for over a year.. thought i was never gonna feel normal again.. (Maybe I don't? :\)

Why do you think withdrawals from a GABAa agonist would have a positive affect with opiates? I believe it would be the same deal.. the withdrawals will mask the opioid affect.
 
Be very careful using opioids during GABAergic withdrawals, since opioids lower the seizure threshold. During a state of GABAergic w/d, your risk of seizing is already high enough, so why take the risk?

Get yourself a proper GHB/GBL tapering tool, like Baclofen or Phenibut, since they also work on the GABA(B) receptors. Even L-Theanine would be a better option for alleviating GBL w/d symptoms, and it's relatively cheap and OTC.

If Phenibut has been too addictive for you in the past, then try to obtain some Baclofen by any means necessary, even if it means opening up to your doctor. Seriously, GBL withdrawals seem to be the most horrid withdrawals of them all, don't underestimate your physical dependency and try to use temporary, marginally effective "band aids" like opiates.
 
I might add that yes, my GHB, GABA-B + GABA-A and opiate receptors are very downregulated. At this point the GABA and GHB receptors are more downregulated than my opiate receptors though.
I have had heavy and long benzo (clonazepam+alprazolam) and opiate (buprenorphine, morphine, ketobemidone, oxycodone) addictions. I have also been on GBL for about 4 weeks now, averaging 18ml~ per day.

I am very familiar with the pharmacology of GABA-A+GABA-B+GHB+opiate agonists and antagonists. I was just curious about the pharmacodynamics of this particular withdrawal/drug interaction, as it struck me as peculiar.

Phenibut and Baclofen would be a godsend, if it were possible to obtain. Unfortunately i live in Sweden, and both are practically impossible to obtain. Baclofen is only prescribed for people with muscle disease and it is extremly rare. So rare in fact that i have only ever heard of it on international forums, and i frequent a number of Swedish drug forums. All that aside, it would be impossible for me to be prescribed anything other than SSRIs (so no benzos, no Z-analogues, no opioids, no lyrica, no gabapentin ETC). This is for several reasons. One reason is that these kinds of medication are hardly ever prescribed in Sweden, even if you have extreme anxiety or depression, all we get is antihistamines and SSRIs. Another reason is that i am young, lower twenties, and they don't prescribe anything that could potentially be addictive or misused to young people. The last reason is that i am flagged in my medical journals as a junky because i have sought help for opiate addiction before and in Sweden all medical institutions and doctors can see all your medical journals, even if they are from other doctors or hospitals/clinics.
 
Yeah, above poster is right. I know that because I'm living also in about same alltitudes with same kind of restrictions. I suppose GBL isn't legal there either?:) Also you can propably get baclofen from doctor if you tell you story and give him enough information (and find good doctor). At least I did even though baclofen is only approved for same reasons as in your country. I suppose its same thing with baclofen everywhere except in France where it is now approved allso for treating alcoholism.

Edit: But as you said your age is a bit problem. When I was in same age it was totally different story... but again, finding good doctor will help.

Edit2: I thought Lyrica was approved in Sweden for treating GAD (generalized anxiety disorder)?
 
jambabomba said:
Yeah, above poster is right. I know that because I'm living also in about same alltitudes with same kind of restrictions. I suppose GBL isn't legal there either?:) Also you can propably get baclofen from doctor if you tell you story and give him enough information (and find good doctor). At least I did even though baclofen is only approved for same reasons as in your country. I suppose its same thing with baclofen everywhere except in France where it is now approved allso for treating alcoholism.

Edit: But as you said your age is a bit problem. When I was in same age it was totally different story... but again, finding good doctor will help.

Edit2: I thought Lyrica was approved in Sweden for treating GAD (generalized anxiety disorder)?
Click to expand...

Lyrica is approved for GAD, but it prescription is very restricted and seeing as my journals say i'm an addict i would not be able to get lyrica, baclofen or gabapentin no matter how badly i needed it. I know this because i've tried in the past, with many different doctors, some very very understanding. But no go. I have no idea where to look for Baclofen, no idea at all.
 
baclofen really is the best drug for this. it really has no recreational potential whatsoever, so it isn't a hard drug to get scripted in my experience.
try telling your doc that you're an hopeless alcoholic, that's how i got it prescribed. not that i was lying, strictly speaking, but at the time GBL/GHB was my problem.
barring that, do a taper with GBL, or better yet GHB. the GBL to GHB conversion is really easy, and can be easily looked up on google. i did a three week taper once after a pretty hefty 3-4 months 24/7 habit and while not exactly pleasant it was bearable. PM me if you have any more questions in that regard.
 
You must log in or register to reply here.
Top