RCs Modafinil Analogues

[Gaz_hmmmm]

Has anyone tried any modafinil analogues such as Flmodafinil (CRL-40,940) or CE-123?

How did they compare, what dosage did you use and how long did they last?

 

[negrogesic]

I've tried CRL-40,940. It is a good alternative to modafinil. I'm trying to remember but from I recall, the duration of action and potency was roughly similar to modafinil.

 

[Gaz_hmmmm]

Is the dosage less?

 

[Xorkoth]

The dosage from some of the analogues (I can't remember what the code negrogesic mentioned refers to, is it fl-modafinil?) is less than modafinil, adrafinil is more since it's just a prodrug. But in my experience, the effects aren't much different. None of them are particularly recreational, they just keep you awake, and give you a little energy and motivation. Pretty decent functional stimulants, but not really "fun" drugs.

 

[plumbus-nine]

We currently have a lot of fluorenol around, which is said to be similar like modafinil (which would rule it out for me, I am with those who get a jittery caffeine OD like effect from it). It has an interesting structure, which reminds me a bit of tricyclic antidepressants (not that I'd like them too much either). Dosage seems to be around 1/2 of modafinil from what I read.

 

[Gaz_hmmmm]

The dosage from some of the analogues (I can't remember what the code negrogesic mentioned refers to, is it fl-modafinil?) is less than modafinil, adrafinil is more since it's just a prodrug. But in my experience, the effects aren't much different. None of them are particularly recreational, they just keep you awake, and give you a little energy and motivation. Pretty decent functional stimulants, but not really "fun" drugs.

I think it is fl-modafinil and I’m not arsed about recreation, I’m trying to combat long-term fatigue.
The anti-depressant properties of modafinil do help though.

We currently have a lot of fluorenol around, which is said to be similar like modafinil (which would rule it out for me, I am with those who get a jittery caffeine OD like effect from it). It has an interesting structure, which reminds me a bit of tricyclic antidepressants (not that I'd like them too much either). Dosage seems to be around 1/2 of modafinil from what I read.

I’d heard of that and apparently it’s a metabolite of a modafinil analogue.
I’ll probably try that too.
The jittery feeling from modafinil goes within a few days of use.

 

[Pastel]

I addition to Modafinil, I've had CRL-40,940 and CRL-40,941.
While CRL-40,940 and Modafinil work, they make me edgy and overdriven during the day. Later in the evening, people have told me that my face look like I about to cry. I've noticed in myself and others, much more aggressive behavior if taking these substances is followed by alcohol consumption. Temperamental women become particularly diagreeble.
I saw very little to none of these negative side-effects with CRL-40,941.


Now it's the second part of 2025. I just learned of CE-123 and it sounds like an absolute dream. The problem is though Red Bull has already applied for patent for using it in their drinks, the only medical in-vivo research has been done on rats. I don't see a single review from anybody taking it. This is quite remarkable for a community which will dive headfirst into trying a recreational chemical with a hazardous analytical profile. I also see it being sold in capsules of 50mg and 125mg. How the hack has this implied dosage been determined while there are no reviews?

 

[4DQSAR]

I would be careful with those Modofinil homologues. One presumes the original researchers studed the QSAR and indeed likely studied the effects of many homologues before settling on what got the GSL.

People seem to forget this - in most patent, Example 1 is the best. With the others, who knows?

 

[red22]

Please help me make a list of all Modafinil analogs

Heterocyclic Analogues of Modafinil as Novel, Atypical Dopamine Transporter Inhibitors

Insighting the inhibitory potential of novel modafinil drug derivatives against estrogen alpha (ERα) of breast cancer through a triple hybrid computational methodology

 

[4DQSAR]

I suggest that beyond choosing the (more) active stereoisomer of Modofinil is likely to reduce any side effects, I note that the class seems to employ the tetrabenazine site of VMAT-2 transport i.e. the same one as methamphetamine (but not amphetamine - which I suggest is an important difference).

 

[sludgekatana]

I've used Flmodafinil (CRL-40,940) quite a bit. It's stronger, my usual dosage has been between 100-200mg. I've dosed it orally and rectally (because I'm a creature of the butt). Rectal dosing doesn't actually lead to a much more pronounced effect personally, but it does hit faster of course. It also has a bit more of a motivational push, but its definitely no amphetamine or anything. The stimulant effect is completely overridden by basically any depressant, just like Modafinil is for me. It does have side effects when the dose is pushed too far, but not as bad as Modafinil.

I just received some CE-123 but haven't tried it yet. Would love to hear some anecdotes about it because I've literally seen zero.

 

[BadBoy377]

What's the best thing to combine with modafinal?

 

[4DQSAR]

What's the best thing to combine with modafinal?

I tried it once. Didn't do anything for me and usually I'm very sensitive to stimulants. I just got on with my day and only in the evening remembered that I had taken it.

 

[BadBoy377]

I've used it a few times. Big doses seem good for study. Combined with Pregabalin a few times seems ok. Mild functional stimulant.

Just wondered if there was any more to it.

 

[4DQSAR]

I've used it a few times. Big doses seem good for study. Combined with Pregabalin a few times seems ok. Mild functional stimulant.

Just wondered if there was any more to it.

Well some people appear to like it. I think it interesting that a lot more research went in to finding more active homologues but for whatever reasons, the only 'improvement' is armodofinil which is simply the more active enantiomer. I estimate the reason for that is what is termed 'evergreening' i.e. finding ways to prolong patent protection with a view to increasing profit. I'm uncertain if the enantiopure compounds really have much of a medical advantage in many cases.

I note flmodafinil (Lauflumide) appears to have stalled in pre-clinical trials. My guess is that if you prevent para hydroxylation of the benzene rings means that duration goes up.

I tend not to provide many trip reports because I recognize that the placebo effect is an inherent bias we all have and that expectation plays a large part of that.

If it works for others, that's fine. It appears to be quite benign although by very definition, there is no such thing as a safe drug.

I also avoid mixing stuff because it's generally the case that we only know of dangerous interactions when bad things happen.

Believe me, I'm as surprised as anyone that I've lived for this long but I strongly suspect that sticking to my meds an then only consuming as prescribed is an important part of that. Stuff I would have got away with thirty years ago would likely kill me now.